Comparison between cone beam computed tomography and panoramic radiography in the assessment of the relationship between the mandibular canal and impacted class C mandibular third molars

Background: Preoperative radiographic evaluation of impacted third molars is essential to determine the proximity to the mandibular canal to minimize the risk of nerve injury. Our study aim was to evaluate the relationship between the mandibular canal and impacted mandibular third molars using cone beam computed tomography (CBCT) and to compare findings therein with panoramic radiographic signs. Methods: CBCT images were taken from 29 patients having 43 Class C impacted mandibular third molars whose panoramic radiographs showed a close relationship between the mandibular canal and mandibular third molars. We evaluated their tomographs to determine the course of the canal, its proximity to the root, any narrowing of the canal, the presence of root grooving or hooks and the proximity of the root to the cortex. A Chi-square test was used for data analysis. Results: The lingual course of the canal was the most frequently detected course in all panoramic findings. Contact of the tooth with the canal was observed in all cases in which panoramic signs of deviation of the canal and darkening of the roots were found. The frequency of observing the narrowing of the canal in CBCT as compared to seeing the presence or the absence of canal narrowing in panoramic radiographs was significantly different (P=0.01). Conclusion: CBCT provides more precise diagnostic information to determine the relationship of impacted third molars to the canal. Deviation of the canal and darkening of the roots in panoramic view can be highly valuable to predict the risk of nerve injury

Prevalence and patterns of palatine and adenoid tonsilloliths in cone-beam computed tomography images of an Iranian population

Background: Tonsilloliths are calcified concretions that develop in tonsillar crypts. They are usually small and asymptomatic, so they are found accidentally during routine dental radiogrphy procedure. Large tonsilloliths can occur with clinical signs and symptoms. The purpose of this study was to evaluate the prevalence and patterns of palatine and adenoid tonsilloliths in cone-beam computed tomography (CBCT) images. Materials and Methods: In this cross-sectional study, 0.5-mm axial and coronal slices of 134 CBCT images were evaluated to determine the presence of palatine and adenoid calcifications. Their patterns such as being unilateral or bilateral as well as single or multiple and their largest linear sizes were reported. Results: Fifty-four (40.3%) patients with palatine tonsilloliths and 17 (12.7%) with adenoid calcifications were found. Thirty (55.6%) palatine tonsilloliths were unilateral, 19 (35.2%) were detected in the left tonsils. Approximately, 54 cases of 78 palatine calcifications were multiple. Seventeen patients had adenoid calcifications that 41.1% of them were unilateral. Fourteen adenoid calcifications were single. The mean ages of patients with palatine tonsilloliths and adenoid calcifications were 45.59 years and 46.53 years, respectively. The range of linear measurements of palatine tonsil calcifications was 0.9–4.2 mm (2.47-mm mean size) while adenoid calcifications ranged from 0.5 to 2.2 mm (0.95-mm mean size). The level of statistical significant difference was <0.05. Conclusion: Gender did not affect total prevalence, the pattern of tonsilar calcifications and their linear sizes. The prevalence of tonsilloliths increased with aging, but this variable did not have an effect on their linear size

Intractable ascites associated with mycophenolate in a simultaneous kidney-pancreas transplant patient: a case report

BACKGROUND: Mycophenolic acid (MPA), either given as an ester pro-drug or as an enteric-coated sodium salt, is the most commonly prescribed anti-proliferative immunosuppressive agent used following organ transplantation and widely applied in immune-mediated diseases. Clinicians are well aware of common adverse reactions related to MPA treatment, in particular diarrhea, leukopenia and infections. Here we report a case of severe, persistent ascites associated with MPA treatment. The otherwise unexplained and intractable ascites, requiring repeated paracenteses for more than 8 months, rapidly ceased with stopping the MPA treatment. To our knowledge this is the first case of severe ascites associated with MPA treatment reported in the scientific literature. CASE PRESENTATION: A 45-year old female with type 1 diabetes mellitus received a simultaneous kidney-pancreas transplant. The surgery was uneventful. However, post-operatively she developed severe transudative ascites requiring in total more than 40 paracenteses treatments draining in the average 2.8 l of ascites fluid. The ascites formation persisted despite exclusion of a surgical complication, fully functioning kidney and pancreas allografts, lack of any significant proteinuria, normalization of circulating albumin levels, intensive use of diuretics and deliberate attempts to increase the intervals between the paracentesis treatments. Various differential diagnoses, including infectious, hepatic, vascular and cardiac causes were ruled out. Nine months after surgery enteric-coated mycophenolate sodium was switched to azathioprine after which ascites completely resolved. When mycophenolate was recommenced abdominal fullness and weight gain reoccurred. The patient had to be switched to long-term azathioprine treatment. More than 1 year post-conversion the patient remains free of ascites. CONCLUSION: MPA is the most widely used antimetabolite immunosuppressive agent. We suggest to consider MPA treatment in the differential diagnosis of severe and unexplained ascites in transplant and non-transplant patients

Evaluation of diagnostically difficult impacted maxillary canines in orthodontic patients and its effect on the root of adjacent teeth using cone beam computed tomography

Purpose: To evaluate the morphology of apical portion of impacted maxillary canines and their effects on root resorption of adjacent teeth as well as their locations and inclinations with cone beam computed tomography (CBCT) in an individual group of orthodontic patients. Materials and Methods: In this descriptive cross-sectional study, 71 diagnostically difficult impacted canines of 55 orthodontic patients were studied with CBCT images. In this group, the orthodontic treatment approaches for eruption of their impacted teeth were not successful. A radiologist opined about the angulation, the position of apical and coronal portion of maxillary canine tooth, resorption of adjacent teeth as well as existence of apical hook and root curvature in reconstructed images. The simultaneous existence of hook and root resorption with other data was subjected to statistical analysis by Chi-square and Fisher′s Exact tests. Results: In this cross-sectional study, the position of crown in buccopalatal dimension were respectively 16.9, 73.2 and 9.9% in buccal, palatal and middle portion of the alveolar bone. Apical hook was seen in 28.2% of cases. Root resorption of the adjacent teeth was induced in 32.3% of the cases, 69.6% of which were slight. Overall, there were no significant statistical differences between the presence of hook, and the positions and angulations of impacted teeth. Conclusions: Apical and palatal positions of crowns of the impacted maxillary canines were the most common locations in the selected groups. The possibility of root resorption of adjacent teeth could be related to angulation of impacted tooth

Integrative Metabolomic and Metallomic Analysis in a Case-Control Cohort With Parkinson's Disease

Parkinson's disease (PD) is a neurodegenerative disease with a complex etiology. Several factors are known to contribute to the disease onset and its progression. However, the complete underlying mechanisms are still escaping our understanding. To evaluate possible correlations between metabolites and metallomic data, in this research, we combined a control study measured using two different platforms. For the different data sources, we applied a Block Sparse Partial Least Square Discriminant Analysis (Block-sPLS-DA) model that allows for proving their relation, which in turn uncovers alternative influencing factors that remain hidden otherwise. We found two groups of variables that trace a strong relationship between metallomic and metabolomic parameters for disease development. The results confirmed that the redox active metals iron (Fe) and copper (Cu) together with fatty acids are the major influencing factors for the PD. Additionally, the metabolic waste product p-cresol sulfate and the trace element nickel (Ni) showed up as potentially important factors in PD. In summary, the data integration of different types of measurements emphasized the results of both stand-alone measurements providing a new comprehensive set of information and interactions, on PD disease, between different variables sources

Population pharmacokinetic and pharmacodynamic modeling of epinephrine administered using a mobile inhaler

Inhaled epinephrine is a potential alternative to self-administered intramuscular epinephrine in imminent anaphylactic reactions. The objective was to develop a pharmacokinetic-pharmacodynamic model describing exposure and effects on heart rate of inhaled epinephrine. Data from a 4-phase cross-over clinical trial in 9 healthy volunteers including 0.3 mg intramuscular epinephrine, two doses of inhaled epinephrine (4 mg/mL solution administered during [mean] 18 and 25 min, respectively) using a mobile pocket inhaler, and an inhaled placebo were analyzed using mixed-effects modeling. Inhaled epinephrine was available almost immediately and more rapidly than via the intramuscular route (absorption half-live 29 min). Epinephrine plasma concentrations declined rapidly after terminating inhalation (elimination half-life 4.1 min) offering the option to stop exposure in case of adverse events. While the expected maximum concentration was higher for inhaled epinephrine, this was not associated with safety concerns due to only moderate additional hemodynamic effects compared to intramuscular administration. Bioavailability after inhalation (4.7%) was subject to high interindividual and inter-occasional variability highlighting that training of inhalation would be essential for patients. The proposed model suggests that the use of a highly concentrated epinephrine solution via inhalation may offer an effective treatment option in anaphylaxis, while efficacy in patients remains to be shown. Copyright (C) 2015, The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved