10,701 research outputs found

    Analysis of the lactose metabolism in E. coli using sum-of-squares decomposition

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    We provide a system-theoretic analysis of the mathematical model of lactose induction in E.coli which predicts the level of lactose induction into the cell for specified values of external lactose. Depending on the levels of external lactose and other parameters, the Lac operon is known to have a low steady state in which it is said to be turned off and high steady state where it is said to be turned on. Furthermore, the model has been shown experimentally to exhibit a bi-stable behavior. Using ideas from Lyapunov stability theory and sum-of-squares decomposition, we characterize the reachable state space for different sets of initial conditions, calculating estimates of the regions of attraction of the biologically relevant equilibria of this system. The changes in the basins of attraction with changes in model parameters can be used to provide biological insight. Specifically, we explain the crucial role played by a small basal transcription rate in the Lac operon. We show that if the basal rate is below a threshold, the region of attraction of the low steady state grows significantly, indicating that system is trapped in the (off) mode, showing the importance of the basal rate of transcription

    Foreign direct investment in Malaysia: Trends and prospects

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    This paper reports on a study analyzing recent trends, pattern and prospects of the foreign direct investment (FDI) in Malaysia in the post-1997 financial crisis period. Among the ASEAN-4 countries, Malaysia continues to remain as the main centre for attracting FDI.The macroeconomic variables such as GDP, exports and employment are found to be positively influenced by the growth of FDI in Malaysia. To enhance the positive effect of FDI on the growth process of the Malaysian economy the flow of FDI into export-oriented sector and use of domestic inputs by the foreign oriented firms need to be encouraged.It is suggested that for sustained flow of FDI, continual price stability, macroeconomic balances, good governance and economic liberalization reforms are crucially important in the country.In the event of declining inflows of FDI, Malaysia has to shiR towards inward looking policies and search other alternatives to sustain its growth and economic prosperity by seeking more investment oufflows as a global player
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