6 research outputs found
Glucosidase-beta variations and Lewy Body Disorders
It has been proposed that there is an increased frequency of
glucosidase-β
mutations in Lewy body disorders. Our comprehensive DNA sequencing approach found a small number of
glucosidase-β
mutations in 101 neuropathologically defined Lewy body disease cases (3%) compared to 99 healthy post-mortem controls (1%); odds ratio 3.0 (95% CI: 0.3 – 29, p=0.3). All three affected carriers were classified as diffuse Lewy body disease (n=3/50; 6%). Our study suggests
glucosidase-β
variants have a limited role in susceptibility to Lewy body disease in North America
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