344 research outputs found
Liposomes modulate human immunodeficiency virus infectivity
We have investigated the effects of the fusion of liposomes with human immunodeficiency virus type 1 (HIV-1(LVA)) on the ability of the virus to infect CD4+ and CD4- cells. Fluorescence dequenching measurements indicated that HIV-1 fuses with liposomes composed of either cardiolipin (CL) or N-[2,3-(dioleyloxy) propyl]-N,N,N-trimethyl ammonium chloride (DOTMA) but not appreciably with dioleoylphosphatidylcholine (DOPC) liposomes. Pre-incubation of HIV-1 with DOTMA liposomes enhanced virus production (measured by p24 gag antigen production in the culture medium and in situ) in CD4+ A3.01 and H9 cells in a concentration-dependent manner, but did not mediate the infection of the CD4- cell line, K562. Preincubation of HIV-1 with between 10 and 30 ÎŒM-DOTMA liposomes, and subsequent incubation with A3.01 cells, resulted in the production of about 30-fold greater levels of virus than controls. The presence of DOTMA liposomes during the incubation of A3.01 cells with HIV-1 enhanced the infectivity of the virus up to 90-fold compared to controls. Conversely, preincubation of HIV-1 with CL liposomes inhibited infection of A3.01 cells, dependent on the concentration of liposomes; DOPC liposomes did not alter the infectivity of the virus under any of the incubation conditions. Our results thus indicate that fusion of HIV-1 with liposomes alters the ability of the virus to infect its target cells
INFORMATION DISTORTIONS IN SOCIAL SYSTEMS: THE UNDERGROUND ECONOMY AND OTHER OBSERVER-SUBJECT-POLICYMAKER FEEDBACKS
A vast array of information about economic activity, political behavior and social trends are summarized in quantitative measures, sometimes in a single number such as GDP. Because of their apparent objectivity, simplicity and universality, these measures are used as a basis for both scientific investigations and in the formulation of public policy. These critical âfactsâ are often subject to what we call observer-subject- policy feedback, an interactive mechanism that can seriously distort and bias the economic, social and political indicators that are typically treated as exogenous observations on our complex systems. In fact, information is often endogenous to the system being studied, and a failure to recognize the observer-subject-policymaker feedback mechanism can result in ârationalâ decisions being based on âirrationalâ information systems. Indeed, we argue that the information content of social indicators is likely to become distorted by the very operation of the economic, social and political institutions they seek to describe. The unobserved economy is an exemplar of this interactive process. Reference: The Underground Economies: Tax Evasion and Information Distortion. Edgar L. Feige (ed.) Cambridge University Press, 1989.Underground Economy, Unobserved Economy,observer-subject- policymaker feedback, information bias, policy distortion.
Diquarks and Exotic Spectroscopy
We propose that the recently discovered \Theta baryon is a bound state of
four quarks and an antiquark, containing two highly correlated ud-pairs. If so,
the \Theta baryon has positive parity, and it lies in an near-ideally mixed
SU(3)_{f} \mathbf{\bar{10}}_{f} oplus \mathbf{8}_{f}. The Roper resonance and
the P_{11}(1710) fit naturally into this classification. We predict an isospin
3/2 multiplet of \Xi's (S=-2) with J^{\Pi}=\half^{+} around 1750 MeV. A search
for manifestly exotic \Xi^{+} and \Xi^{--} in this mass range could provide a
sharp test of our proposal. We predict that charm and bottom analogues of the
\Theta baryon are stable against strong decays.Comment: 5 pages, 2 figures, revtex 4, minor corrections and revisions for
journal publicatio
Color superconductivity in weak coupling
We derive perturbatively the gap equations for a color-superconducting
condensate with total spin J=0 in dense QCD. At zero temperature, we confirm
the results of Son for the dependence of the condensate on the coupling
constant, and compute the prefactor to leading logarithmic accuracy. At nonzero
temperature, we find that to leading order in weak coupling, the temperature
dependence of the condensate is identical to that in BCS-like theories. The
condensates for total spin J=1 are classified; to leading logarithmic accuracy
these condensates are of the same order as those of spin J=0.Comment: 30 pages, 3 figures, RevTeX, epsf and psfig style files require
Superfluidity in a Model of Massless Fermions Coupled to Scalar Bosons
We study superfluidity in a model of massless fermions coupled to a massive
scalar field through a Yukawa interaction. Gap equations for a condensate with
total spin J=0 are solved in the mean-field approximation. For the Yukawa
interaction, the gaps for right- and left-handed fermions are equal in
magnitude and opposite in sign, so that condensation occurs in the J^P = 0^+
channel. At finite scalar mass, there are two different gaps for fermions of a
given chirality, corresponding to condensation of particle pairs or of
antiparticle pairs. These gaps become degenerate in the limit of infinite
scalar mass.Comment: 26 pages, 9 figures, RevTeX, epsf and psfig style files required.
Revised version, discussion of the excitation spectrum extended, Fig. 2 adde
A first order transition and parity violation in a color superconductor
In cold, dense quark matter, quarks of different flavor can form Cooper pairs
which are anti-triplets under color and have total spin J=0. The transition to
a phase where strange quarks condense with either up or down quarks is driven
first order by the Coleman-Weinberg mechanism. At densities sufficiently high
to (effectively) restore the axial U(1) symmetry, then relative to the ordinary
vacuum, the condensation of up with down quarks (effectively) breaks parity
spontaneously.Comment: 4 pages, ReVTeX, final versio
Vortices in (2+1)d Conformal Fluids
We study isolated, stationary, axially symmetric vortex solutions in
(2+1)-dimensional viscous conformal fluids. The equations describing them can
be brought to the form of three coupled first order ODEs for the radial and
rotational velocities and the temperature. They have a rich space of solutions
characterized by the radial energy and angular momentum fluxes. We do a
detailed study of the phases in the one-parameter family of solutions with no
energy flux. This parameter is the product of the asymptotic vorticity and
temperature. When it is large, the radial fluid velocity reaches the speed of
light at a finite inner radius. When it is below a critical value, the velocity
is everywhere bounded, but at the origin there is a discontinuity. We comment
on turbulence, potential gravity duals, non-viscous limits and non-relativistic
limits.Comment: 39 pages, 10 eps figures, v2: Minor changes, refs, preprint numbe
The QCD spectrum with three quark flavors
We present results from a lattice hadron spectrum calculation using three
flavors of dynamical quarks - two light and one strange, and quenched
simulations for comparison. These simulations were done using a one-loop
Symanzik improved gauge action and an improved Kogut-Susskind quark action. The
lattice spacings, and hence also the physical volumes, were tuned to be the
same in all the runs to better expose differences due to flavor number. Lattice
spacings were tuned using the static quark potential, so as a byproduct we
obtain updated results for the effect of sea quarks on the static quark
potential. We find indications that the full QCD meson spectrum is in better
agreement with experiment than the quenched spectrum. For the 0++ (a0) meson we
see a coupling to two pseudoscalar mesons, or a meson decay on the lattice.Comment: 38 pages, 20 figures, uses epsf. 5/29/01 revision responds to
referee's Comments, changes pion fits and tables, and corrects Fig. 10 and
some minor error
Reaction rates and transport in neutron stars
Understanding signals from neutron stars requires knowledge about the
transport inside the star. We review the transport properties and the
underlying reaction rates of dense hadronic and quark matter in the crust and
the core of neutron stars and point out open problems and future directions.Comment: 74 pages; commissioned for the book "Physics and Astrophysics of
Neutron Stars", NewCompStar COST Action MP1304; version 3: minor changes,
references updated, overview graphic added in the introduction, improvements
in Sec IV.A.
Recommended from our members
Micropolarizing device for long wavelength infrared polarization imaging.
The goal of this project is to fabricate a four-state pixelated subwavelength optical device that enables mid-wave infrared (MWIR) or long-wave infrared (LWIR) snapshot polarimetric imaging. The polarization information can help to classify imaged materials and identify objects of interest for numerous remote sensing and military applications. While traditional, sequential polarimetric imaging produces scenes with polarization information through a series of assembled images, snapshot polarimetric imaging collects the spatial distribution of all four Stokes parameters simultaneously. In this way any noise due to scene movement from one frame to the next is eliminated. We fabricated several arrays of subwavelength components for MWIR polarization imaging applications. Each pixel unit of the array consists of four elements. These elements are micropolarizers with three or four different polarizing axis orientations. The fourth element sometimes has a micro birefringent waveplate on the top of one of the micropolarizers. The linear micropolarizers were fabricated by patterning nano-scale metallic grids on a transparent substrate. A large area birefringent waveplate was fabricated by deeply etching a subwavelength structure into a dielectric substrate. The principle of making linear micropolarizers for long wavelengths is based upon strong anisotropic absorption of light in the nano-metallic grid structures. The nano-metallic grid structures are patterned with different orientations; therefore, the micropolarizers have different polarization axes. The birefringent waveplate is a deeply etched dielectric one-dimensional subwavelength grating; therefore two orthogonally polarized waves have different phase delays. Finally, in this project, we investigated the near field and diffractive effects of the subwavelength element apertures upon detection. The fabricated pixelated polarizers had a measured extinction ratios larger than 100:1 for pixel sizes in the order of 15 {micro}m by 15 {micro}m that exceed by 7 times previously reported devices. The fabricated birefringent diffractive waveplates had a total variation of phase delay rms of 9.41 degrees with an average delay of 80.6 degrees across the MWIR spectral region. We found that diffraction effects change the requirement for separation between focal plane arrays (FPA) micropolarizer arrays and birefringent waveplates arrays, originally in the order of hundreds of microns (which are the typical substrate thickness) to a few microns or less. This new requirement leads us to propose new approaches to fabricate these devices
- âŠ