A comprehensive approach to the hygienic assessment of students’ quality of life

At the present stage of development of society the problem of quality of life of young people, including young students, as a social group, is quite relevant. Despite the significant discrepancies in the interpretation of the concept of «quality of life», most authors agree that the defining components of this concept are the health status and satisfaction with the individual's own life. In the study of problems of the quality of life of students in the form of the original definition was accepted definition of quality of life as a phenomenon that entails psycho-physiological and physical health of man, his spiritual and cultural values, the level of civilization of a society and its economic development. The article presents the results of the hygienic assessment of students' quality of life, which suggest the applicability of both objective and subjective characteristics of life quality in studies. It is associated with the dynamics of life quality indicators, the changeability of the influencing factors, and the necessity of regular monitoring of life quality indicators and factors supposed to be focal in its formation. Basing on the material obtained in the course of the experimental work, the authors formulate the fundamental principles of the comprehensive approach to the hygienic assessment of quality of life. This concept, in contrast to the WHO concept of quality of life assessment in clinical medicine, based on four principles: multi-dimensionality, the change indicators over time, the active participation of the individual in the assessment of their condition, a comparison of subjective assessments with objective measures

MODERN CAPABILITIES OF THERAPY OF POST-VIRAL RHINOSINUSITIS IN CHILDREN

The article focuses on the treatment of respiratory viral infections of the ENT organs in order to prevent complications and chronicity of the process. It provides the data on the efficacy of the use of polidexa with phenylephrine in paediatric patient with acute post-viral rhinosinusitis. The microbiological tests and changes observed in imprint smears from the mucous membrane of the nasal cavity showed that the drug reduces the clinical manifestations of the disease quickly and significantly, has a sanative effect and positively affects the quality of life of patients

CHANGES IN INTRACELLULAR POTENTIALS AND ION FLUXES OF NEURONS OF MOLLUSKS BY EXTRACELLULAR AND INTRACELLULAR ACTION OF SEVOFLURANE AND DESFLURANE

Intercellular potentials changes of identifiable intact neurons ini solated CNS of great ramshorn (Planorbarius corneus) have been investigated with the help of intercellular microelectrodes and ion currents of isolated neurons of great ramshorns and pond snails (Lymnaea stagnalis) with the fixation of potential influenced by desflurane in concentrations of 1 and 10 mM (1.2 и 12 MAC) and sevoflurane in concentrations of 1 and 5 mM (2.27 and 11.36 MAC). In 3-5 minutes after the start of anesthetics' action some neurons developed insignificant hyperpolarization (for 2-5 mV), and some other developed depolarization (up to 10 mV). When anesthetics were being washed out for 5-10 minutes the reversible depolarization appeared. Changes in ion currents under the influence of anesthetics were more homogeneous compared to changes in biopotentials. Desflurane and sevoflurane in 1 mM concentrations suppressed amplitudes of sodium, calcium and potassium currents by 40%, and inactivation of potassium low currents was speed up. Anesthetics in the concentration of 5-10 mM suppressed currents by 70-80%. It developed fast (for 20-30 seconds) and after this action the amplitudes restored slowly (for 5-15 minutes) and it failed to reach the initial values in all the times. Intercellular activity of sevoflurane did not suppress ion currents, i.e. it was ineffective

ИЗМЕНЕНИЯ ВНУТРИКЛЕТОЧНЫХ ПОТЕНЦИАЛОВ И ИОННЫХ ТОКОВ НЕЙРОНОВ МОЛЛЮСКОВ ПРИ ВНЕ- И ВНУТРИКЛЕТОЧНОМ ДЕЙСТВИИ СЕВОФЛУРАНА И ДЕСФЛУРАНА

Intercellular potentials changes of identifiable intact neurons ini solated CNS of great ramshorn (Planorbarius corneus) have been investigated with the help of intercellular microelectrodes and ion currents of isolated neurons of great ramshorns and pond snails (Lymnaea stagnalis) with the fixation of potential influenced by desflurane in concentrations of 1 and 10 mM (1.2 и 12 MAC) and sevoflurane in concentrations of 1 and 5 mM (2.27 and 11.36 MAC). In 3-5 minutes after the start of anesthetics' action some neurons developed insignificant hyperpolarization (for 2-5 mV), and some other developed depolarization (up to 10 mV). When anesthetics were being washed out for 5-10 minutes the reversible depolarization appeared. Changes in ion currents under the influence of anesthetics were more homogeneous compared to changes in biopotentials. Desflurane and sevoflurane in 1 mM concentrations suppressed amplitudes of sodium, calcium and potassium currents by 40%, and inactivation of potassium low currents was speed up. Anesthetics in the concentration of 5-10 mM suppressed currents by 70-80%. It developed fast (for 20-30 seconds) and after this action the amplitudes restored slowly (for 5-15 minutes) and it failed to reach the initial values in all the times. Intercellular activity of sevoflurane did not suppress ion currents, i.e. it was ineffective. Проведены исследования изменений внутриклеточных потенциалов идентифицируемых интактных нейронов изолированной ЦНС моллюска катушки роговой (Planorbarius corneus) с помощью внутриклеточных микроэлектродов и ионных токов изолированных нейронов катушки и прудовика (Lymnaea stagnalis) в условиях фиксации потенциала под влиянием десфлурана в концентрациях 1 и 10 мМ (1,2 и 12 МАК) и севофлурана в концентрациях 1 и 5 мМ (2,27 и 11,36 МАК). Через 3-5 мин от начала действия анестетиков в одних нейронах развивалась незначительная гиперполяризация (на 2-5 мВ), а в других - деполяризация (до 10 мВ). При отмывании анестетиков в течение 5-10 мин возникала обратимая гиперполяризация. Изменения ионных токов под влиянием анестетиков оказались более однородными, чем изменения биопотенциалов. При действии десфлурана и севофлурана в концентрации 1 мМ происходило подавление амплитуд натриевых, кальциевых и калиевых токов на 40%, при этом наблюдалось ускорение инактивации калиевых медленных токов. Под влиянием анестетиков в концентрации 5-10 мМ происходило подавление токов на 70-80%. Оно развивалось быстро (за 20-30 с), а после их действия восстановление амплитуд ионных токов было замедленным (за 5-15 мин) и не всегда достигало исходных величин. Внутриклеточное действие севофлурана не подавляло ионные токи, т. е. было неэффективным