Psychometrics of health-related quality of life questionnaires in bronchiectasis:A systematic review and meta-analysis

INTRODUCTION: Understanding the psychometric properties of health related quality of life (HRQoL) questionnaires can help inform selection in clinical trials. OBJECTIVE: To assess the psychometric properties of HRQoL questionnaires in bronchiectasis. METHODS: A literature search was conducted. HRQoL questionnaires were assessed for psychometric properties (reliability, validity, minimal clinically important difference (MCID), floor/ceiling effects). Meta-analyses assessed the associations of HRQoL with clinical measures and responsiveness of HRQoL in clinical trials. RESULTS: 166 studies and 12 HRQoL questionnaires were included. The BHQ, LCQ, CAT and SF-36 had good internal consistency in all domains reported (Cronbach's α≥0.7) across all studies and the QoL-B, SGRQ, CRDQ and SOLQ had good internal consistency in all domains in the majority of (but not all) studies. The BHQ, SGRQ, LCQ and CAT had good test-retest reliability in all domains reported ((intraclass correlation coefficient) ICC ≥0.7) across all studies and the QoL-B, CRDQ and SOLQ had good test-retest reliability in all domains in the majority of (but not all) studies. HRQoL questionnaires were able to discriminate between demographics, important markers of clinical status, disease severity, exacerbations and bacteriology. For HRQoL responsiveness, there was a difference between the treatment and placebo effect. CONCLUSION: SGRQ was the most widely used HRQoL questionnaire in bronchiectasis studies and it had good psychometric properties, however good psychometric data are growing on bronchiectasis specific HRQoL questionnaires, QoL-B and BHQ. Future studies should focus on the medium-long term test-retest reliability, responsiveness and MCID in these HRQoL questionnaires which show potential in bronchiectasis

Data extraction sheets for "Psychometrics of health-related quality of life questionnaires in bronchiectasis: A systematic review and meta-analysis"

This dataset contains data extraction sheets related to the following published article: "Psychometrics of health-related quality of life questionnaires in bronchiectasis: A systematic review and meta-analysis" (2021). This journal was published in the European Respiratory Journal. The dataset includes 5 spreadsheets in xlsx format: (i) correlations data, (ii) psychometrics data, (iii) responsiveness data, (iv) quality assessment & (v) translated studies. The dataset is also available in CSV format in 6 spreadsheets: (i) correlations data, (ii) psychometrics data, (iii) responsiveness data: Datasheet (iv) responsiveness data: Data dictionary sheet (v) translated studies & (vi) quality assessment. This data is the raw data which was used to write the review and perform the meta-analysis. This dataset would benefit other researchers who are interested in publishing similar reviews in order to publish valid and reliable data. Note that this research was conducted in chapter 2 of the related thesis entitled "Clinical and microbiological endpoints in chronic airway diseases" (2022). Please note that this thesis is embargoed until 31 July 2025