Structure of (22\u3cem\u3eS\u3c/em\u3e)-3\u3cem\u3eβ\u3c/em\u3e-Acetoxy-20-(3-isopropylisoxazolin-5-yl)-4,4,14 \u3cem\u3eα\u3c/em\u3e-trimethylpregn-8(9)-ene

C32H51NO3, Mr = 497·7, orthorhombic, P212121, a = 7·577 (2), b = 10·510 (2), c = 35·399 (7) Å, V = 2819 (1) Å3, Z = 4, Dx = 1·173 g cm-3, λ (Mo Kα) = 0·71073 Å, μ = 0·69 cm-1, F(000) = 1096, T = 153 K, R = 0·0497 for 2235 observed reflections. The compound investigated is found to be a (22S)-epimer

The Sequence of a Stepwise AdE Reaction and Intramolecular Pauson-Khand Cycloaddition as an Entry into the Synthesis of Polycyclic Compounds

A stepwise AdE acylmethoxylation across the double bond of dicobalt hexacarbonyl complexes (DCHCC) of conjugated enynes was elaborated as an efficient and general route for the synthesis of DCHCC of 1,6-enynes containing a combination of five- and six-membered-ring fragments. Depending on the structure of these adducts, the latter either were subjected to 1,2-carbnyl reduction followed by an intramolecular Pauson-Khand (IMPK) cyclization or were directly utilized as substrates for this process. A list of model polycyclic systems which were assembled using this approach includes [5.5.5] angularly fused compounds, [6.5.5] and [5.5.5] linearly fused tricyclics, and linearly and angularly fused [6.5.5.5] and [5.5.5.5] tetracyclic products. A novel convergent and general method for the synthesis of various cyclic compounds is suggested on the basis of the AdE-IMPK tandem sequence as the key steps for the assemblage of polycyclic frameworks. This option seems to be especially promising for the tetracyclic derivatives mentioned above, as in these cases only two operationally simple steps are required to convert read:\u27-/ available starting blocks into the target structures related to natural polyquinanes