Genetic liability to cannabis use disorder and COVID-19 hospitalization

BACKGROUND: Vulnerability to COVID-19 hospitalization has been linked to behavioral risk factors, including combustible psychoactive substance use (e.g., tobacco smoking). Paralleling the COVID-19 pandemic crisis have been increasingly permissive laws for recreational cannabis use. Cannabis use disorder (CUD) is a psychiatric disorder that is heritable and genetically correlated with respiratory disease, independent of tobacco smoking. We examined the genetic relationship between CUD and COVID-19 hospitalization. METHODS: We estimated the genetic correlation between CUD (case: RESULTS: Genetic vulnerability to COVID-19 was correlated with genetic liability to CUD ( CONCLUSIONS: Problematic cannabis use and vulnerability to serious COVID-19 complications share genetic underpinnings that are unique from common correlates. While CUD may plausibly contribute to severe COVID-19 presentations, causal inference models yielded no evidence of putative causation. Curbing excessive cannabis use may mitigate the impact of COVID-19

A Spitzer Spectroscopic Survey of Low Ionization Nuclear Emission-line Regions: Characterization of the Central Source

We have conducted a comprehensive mid-IR spectroscopic investigation of 67 Low Ionization Nuclear Emission Line Regions (LINERs) using archival observations from the high resolution modules of the Infrared Spectrograph on board the Spitzer Space Telescope. Using the [NeV] 14 and 24um lines as active galactic nuclei (AGN) diagnostics, we detect active black holes in 39% of the galaxies in our sample, many of which show no signs of activity in either the optical or X-ray bands. In particular, a detailed comparison of multi-wavelength diagnostics shows that optical studies fail to detect AGN in galaxies with large far-IR luminosities. These observations emphasize that the nuclear power source in a large percentage of LINERs is obscured in the optical. Indeed, the majority of LINERs show mid-IR [NeV]14/[NeV]24um flux ratios well below the theoretical low-density limit, suggesting that there is substantial extinction toward even the [NeV]-emitting region . Combining optical, X-ray, and mid-IR diagnostics, we find an AGN detection rate in LINERs of 74%, higher than previously reported statistics of the fraction of LINERs hosting AGN. The [NeV]24um /[OIV]26um mid-IR line flux ratio in "AGN-LINERs" is similar to that of standard AGN, suggesting that the spectral energy distribution (SED) of the intrinsic optical/UV continuum is similar in the two. This result is in contrast to previous suggestions of a UV deficit in the intrinsic broadband continuum emission in AGN-LINERs. Consistent with our finding of extinction to the [NeV]-emitting region, we propose that extinction may also be responsible for the observed optical/UV deficit seen in at least some AGN-LINERs.Comment: Accepted for publication in Ap

Enhanced activity of massive black holes by stellar capture assisted by a self-gravitating accretion disc

We study the probability of close encounters between stars from a nuclear cluster and a massive black hole. The gravitational field of the system is dominated by the black hole in its sphere of influence. It is further modified by the cluster mean field (a spherical term) and a gaseous disc/torus (an axially symmetric term) causing a secular evolution of stellar orbits via Kozai oscillations. Intermittent phases of large eccentricity increase the chance that stars become damaged inside the tidal radius of the central hole. Such events can produce debris and lead to recurring episodes of enhanced accretion activity. We introduce an effective loss cone and associate it with tidal disruptions during the high-eccentricity phases of the Kozai cycle. By numerical integration of the trajectories forming the boundary of the loss cone we determine its shape and volume. We also include the effect of relativistic advance of pericentre. The potential of the disc has the efffect of enlarging the loss cone and, therefore, the predicted number of tidally disrupted stars should grow by factor of ~10^2. On the other hand, the effect of the cluster mean potential together with the relativistic pericentre advance act against the eccentricity oscillations. In the end we expect the tidal disruption events to be approximately ten times more frequent in comparison with the model in which the three effects -- the cluster mean field, the relativistic pericentre advance, and the Kozai mechanism -- are all ignored. The competition of different influences suppresses the predicted star disruption rate as the black hole mass increases. Hence, the process under consideration is more important for intermediate-mass black holes, M_bh~10^4M_s.Comment: 10 pages, 5 figures; Astronomy & Astrophysics accepte

The contribution of X-ray binaries to the evolution of late-type galaxies: Evolutionary population synthesis simulations

X-ray studies of normal late-type galaxies have shown that non-nuclear X-ray emission is typically dominated by X-ray binaries, and provides a useful measure of star formation activity. We have modeled the X-ray evolution of late-type galaxies over the $\sim$ 14 Gyr of cosmic history, with an evolutionary population synthesis code developed by Hurley et al. Our calculations reveal a decrease of the X-ray luminosity-to-mass ratio $L_{\rm X}/M$ with time, in agreement with observations (Fig.~7$a$). We show that this decrease is a natural consequence of stellar and binary evolution and mass accumulating process in galaxies. The X-ray-to-optical luminosity ratio $L_{\rm X}/L_{\rm B}$ is found to be fairly constant (around $\sim 10^{30}$ erg\,s$^{-1}$$L_{\rm B,\odot}^{-1}$, Fig.~7$b$), and insensitive to the star formation history in the galaxies. The nearly constant value of $L_{\rm X}/L_{\rm B}$ is in conflict with the observed increase in $L_{\rm X}/L_{\rm B}$ from $z=0$ to 1.4. The discrepancy may be caused by intense obscured star formation activity that leads to nonlinear relationship between X-ray and B-band emission.Comment: 8 figures, 1 table, accepted for publication in the Astrophysical Journal, now available at http://stacks.iop.org/0004-637X/733/

VirMAP for Cancer: Characterization of the Intratumoral Virome in Virally-Associated Cancers and a Resource for Investigators

View full abstracthttps://openworks.mdanderson.org/leading-edge/1040/thumbnail.jp

The Nature of Optically Dull Active Galactic Nuclei in COSMOS

We present infrared, optical, and X-ray data of 48 X-ray bright, optically dull AGNs in the COSMOS field. These objects exhibit the X-ray luminosity of an active galactic nucleus (AGN) but lack broad and narrow emission lines in their optical spectrum. We show that despite the lack of optical emission lines, most of these optically dull AGNs are not well-described by a typical passive red galaxy spectrum: instead they exhibit weak but significant blue emission like an unobscured AGN. Photometric observations over several years additionally show significant variability in the blue emission of four optically dull AGNs. The nature of the blue and infrared emission suggest that the optically inactive appearance of these AGNs cannot be caused by obscuration intrinsic to the AGNs. Instead, up to ~70% of optically dull AGNs are diluted by their hosts, with bright or simply edge-on hosts lying preferentially within the spectroscopic aperture. The remaining ~30% of optically dull AGNs have anomalously high f_x/f_o ratios and are intrinsically weak, not obscured, in the optical. These optically dull AGNs are best described as a weakly accreting AGN with a truncated accretion disk from a radiatively inefficient accretion flow.Comment: 12 pages, 10 figures. Accepted for publication in the Ap

On the formation and evolution of black-hole binaries

We present the results of a systematic study of the formation and evolution of binaries containing black holes and normal-star companions with a wide range of masses. We first reexamine the standard formation scenario for close black-hole binaries, where the spiral-in of the companion in the envelope of a massive star causes the ejection of the envelope. We estimate the formation rates for different companion masses and different assumptions about the common-envelope structure and other model parameters. We find that black-hole binaries with intermediate- and high-mass secondaries can form for a wide range of assumptions, while black-hole binaries with low-mass secondaries can only form with apparently unrealistic assumptions (in agreement with previous studies). We then present detailed binary evolution sequences for black-hole binaries with secondaries of 2 to 17 Msun and demonstrate that in these systems the black hole can accrete appreciably even if accretion is Eddington limited (up to 7 Msun for an initial black-hole mass of 10 Msun) and that the black holes can be spun up significantly in the process. We discuss the implications of these calculations for well-studied black-hole binaries (in particular GRS 1915+105), ultra-luminous X-ray sources and Cygnus X-1. Finally, we discuss how some of the assumptions in the standard model could be relaxed to allow the formation of low-mass, short-period black-hole binaries which appear to be very abundant in Nature. (Abstract abridged)Comment: 21 pages, 9 figures, accepted by MNRAS, Figs. 2a/2b and 5 in very reduced forma