Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Blowing Pressure, Power and Spectrum in Trumpet Playing

Measurements of sound output as a function of blowing pressure are reported for a group of experienced trumpet players. The study identifies several common features, namely (1) a threshold blowing pressure approximately proportional to the frequency of the note being played, (2) an extended region in which the sound output rises by about 15 dB for each doubling of blowing pressure, and (3) a saturation region in which sound output rises by only about 3 dB for a doubling of blowing pressure. Some players are able to blow with maximum pressures as high as 25 kPa, which is significantly greater than normal systolic blood pressure. A simple theory is presented that provides a physical explanation for the acoustical behavior, but a detailed treatment requires solution of the nonlinear coupled equations both for the lip-valve mechanism and for nonlinear wave propagation in the instrument tube. Frequency analysis of the sound shows a basic spectral envelope determined by the resonance properties of the mouthpiece cup and the radiation behavior of the bell, supplemented by an extension to increasingly high frequencies as the blowing pressure is increased. This high-frequency behavior can be attributed to nonlinear wavefront steepening during sound propagation along the cylindrical bore of the instrument