Balancing Selection Pressures, Multiple Objectives, and Neural Modularity to Coevolve Cooperative Agent Behavior

Previous research using evolutionary computation in Multi-Agent Systems indicates that assigning fitness based on team vs.\ individual behavior has a strong impact on the ability of evolved teams of artificial agents to exhibit teamwork in challenging tasks. However, such research only made use of single-objective evolution. In contrast, when a multiobjective evolutionary algorithm is used, populations can be subject to individual-level objectives, team-level objectives, or combinations of the two. This paper explores the performance of cooperatively coevolved teams of agents controlled by artificial neural networks subject to these types of objectives. Specifically, predator agents are evolved to capture scripted prey agents in a torus-shaped grid world. Because of the tension between individual and team behaviors, multiple modes of behavior can be useful, and thus the effect of modular neural networks is also explored. Results demonstrate that fitness rewarding individual behavior is superior to fitness rewarding team behavior, despite being applied to a cooperative task. However, the use of networks with multiple modules allows predators to discover intelligent behavior, regardless of which type of objectives are used

Evidence for the impact of Reactive oxygen species on the control of branching in Neurospora crassa

In preliminary screens, several functions, most notably, genes involved in the control of reactive oxygen species (ROS), were identified as playing a role in the process of growth rate compensation of branch density. The maintenance of branch density under growth at various temperatures was examined in a selection of mutants in genes known to be important in the control of ROS. In all ROS control mutants tested, growth was shown to branch tighter when grown at higher temperatures (which result in faster growth rates) and looser when grown at lower temperatures (which results in slower growth rates). This can be contrasted with wild-type Neurospora which branches at the same density under both conditions. We also tested the impact of environmental agents which lower the concentration of ROS on branching. In tests, various water soluble anti-oxidants (ie reducing agents); Ascorbic Acid (aka Vitamin C) and Glutathione produced unusual bra nching patterns in wild-type Neurospora strains exposed

FM-track: a fiducial marker tracking software for studying cell mechanics in a three-dimensional environment

Tracking the deformation of fiducial markers in the vicinity of living cells embedded in compliant synthetic or biological gels is a powerful means to study cell mechanics and mechanobiology in three-dimensional environments. However, current approaches to track and quantify three-dimensional (3D) fiducial marker displacements remain ad-hoc, can be difficult to implement, and may not produce reliable results. Herein, we present a compact software package entitled “FM-Track,” written in the popular Python language, to facilitate feature-based particle tracking tailored for 3D cell micromechanical environment studies. FM-Track contains functions for pre-processing images, running fiducial marker tracking, and post-processing and visualization. FM-Track can thus aid the study of cellular mechanics and mechanobiology by providing an extensible software platform to more reliably extract complex local 3D cell contractile information in transparent compliant gel systems.https://www.sciencedirect.com/science/article/pii/S2352711019303474Published versio

ActiveRemediation: The Search for Lead Pipes in Flint, Michigan

We detail our ongoing work in Flint, Michigan to detect pipes made of lead and other hazardous metals. After elevated levels of lead were detected in residents' drinking water, followed by an increase in blood lead levels in area children, the state and federal governments directed over $125 million to replace water service lines, the pipes connecting each home to the water system. In the absence of accurate records, and with the high cost of determining buried pipe materials, we put forth a number of predictive and procedural tools to aid in the search and removal of lead infrastructure. Alongside these statistical and machine learning approaches, we describe our interactions with government officials in recommending homes for both inspection and replacement, with a focus on the statistical model that adapts to incoming information. Finally, in light of discussions about increased spending on infrastructure development by the federal government, we explore how our approach generalizes beyond Flint to other municipalities nationwide.Comment: 10 pages, 10 figures, To appear in KDD 2018, For associated promotional video, see https://www.youtube.com/watch?v=YbIn_axYu9