Solar Radiation Pressure Resonances in Low Earth Orbits

The aim of this work is to highlight the crucial role that orbital resonances associated with solar radiation pressure can have in Low Earth Orbit. We review the corresponding literature, and provide an analytical tool to estimate the maximum eccentricity which can be achieved for well-defined initial conditions. We then compare the results obtained with the simplified model with the results obtained with a more comprehensive dynamical model. The analysis has important implications both from a theoretical point of view, because it shows that the role of some resonances was underestimated in the past, but also from a practical point of view in the perspective of passive deorbiting solutions for satellites at the end-of-life

Atlantis II : cruise 102 : moored and shipboard surface meteorological measurements during JASIN 1978

During cruise 102 of the R/V Atlantis-II in the Joint Air-Sea Interaction Project (JASIN), surface meteorological data were gathered by Woods Hole Oceanographic Institution personnel from two moored buoys and from the ship. One buoy (JASIN W2/WHOI 651) carried a Vector Averaging Wind Recorder (VAWR) and a Vector Measuring Wind Recorder (VMWR); these instruments provided 18 days of intercomparison data and 38 days of meteorological data from 30 July to 6 September 1978. The other buoy (JASIN H2) carried a VMWR and gave 25 total days of data from 16 July to 10 August, and from 26 August to 1 September. A PET computer, hardwired to sensors positioned on the ship, displayed data that were logged during both legs of the cruise. Manual data were gathered by the science watches. This report describes the PET system, and displays and compares all the data. VAWR hourly meteorological data are listed for the 38 day period. Scientific interpretation of these data, such as calculations of heat fluxes, will be published separately.Prepared for the National Science Foundation under Grants OCE77-25803 and OCE76-80174, and for the Office of Naval Research under Contract N00014-76-C-0197; NR 083-400 to the Woods Hole Oceanographic Institution

Neutrino oscillation physics at an upgraded CNGS with large next generation liquid Argon TPC detectors

The determination of the missing $U_{e3}$ element (magnitude and phase) of the PMNS neutrino mixing matrix is possible via the detection of \numu\to\nue oscillations at a baseline $L$ and energy $E$ given by the atmospheric observations, corresponding to a mass squared difference $E/L \sim \Delta m^2\simeq 2.5\times 10^{-3} eV^2$. While the current optimization of the CNGS beam provides limited sensitivity to this reaction, we discuss in this document the physics potential of an intensity upgraded and energy re-optimized CNGS neutrino beam coupled to an off-axis detector. We show that improvements in sensitivity to $\theta_{13}$ compared to that of T2K and NoVA are possible with a next generation large liquid Argon TPC detector located at an off-axis position (position rather distant from LNGS, possibly at shallow depth). We also address the possibility to discover CP-violation and disentangle the mass hierarchy via matter effects. The considered intensity enhancement of the CERN SPS has strong synergies with the upgrade/replacement of the elements of its injector chain (Linac, PSB, PS) and the refurbishing of its own elements, envisioned for an optimal and/or upgraded LHC luminosity programme.Comment: 37 pages, 20 figure

Quantitative Documentation of the Therapeutic Efficacy of Adolescent Telepsychiatry

The following is a case report of a 15-year-old adolescent who was evaluated and treated via telepsychiatry as part of an ongoing project at the University of Michigan Health System and the Hiawatha Community Mental Health Center in Michigan. In addition to clinical information, prospective quantitative data was collected at baseline, 6 weeks, and 3 months. Measures included the Youth Self Report (YSR), Child Behavior Checklist (CBCL), Suicide Probability Scale (SPS), Reynold's Adolescent Depression Scale (RADS), Connor's Global Index—Parent Version (CGI-P), and the Children's Global Assessment Scale (CGAS). Prior to the telepsychiatry intervention, the patient was diagnosed as having bipolar disorder with psychosis. During the telepsychiatry intervention, the diagnosis was altered to a posttraumatic stress disorder; medications were discontinued and the patient improved. All scales showed reductions in severity of symptoms after the telepsychiatry interventions. This case represents the first application of adolescent telepsychiatry for the diagnosis, treatment, and tracking of clinical symptoms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63270/1/153056203322502678.pd

Mechanism of activation of SGK3 by growth factors-via the Class 1 and Class 3 PI3Ks

Derailment of the PI3K-AGC protein kinase signalling network contributes to many human diseases including cancer. Recent work has revealed that the poorly studied AGC kinase family member, SGK3 promotes resistance to cancer therapies that target the Class 1 PI3K pathway, by substituting for loss of Akt kinase activity. SGK3 is recruited and activated at endosomes, by virtue of its PX domain binding to PtdIns(3)P. Here we demonstrate that endogenous SGK3 is rapidly activated by growth factors such as IGF1, through pathways involving both Class 1 and Class 3 PI3Ks. We provide evidence that IGF1 enhances endosomal PtdIns(3)P levels via a pathway involving the UV-RAG complex of hVPS34 Class 3 PI3K. Our data points towards IGF1 induced activation of Class 1 PI3K stimulating SGK3 through enhanced production of PtdIns(3)P resulting from the dephosphorylation of PtdIns(3,4,5)P3 Our findings are also consistent with activation of Class 1 PI3K promoting mTORC2 phosphorylation of SGK3 and with oncogenic Ras activating SGK3 solely through the Class 1 PI3K pathway. Our results highlight the versatility of upstream pathways that activate SGK3 and help explain how SGK3 substitutes for Akt following inhibition of Class 1 PI3K/Akt pathways. They also illustrate robustness of SGK3 activity that can remain active and counteract physiological conditions or stresses where either Class 1 or Class 3 PI3K pathways are inhibited.</p