Common-mode rejection in Martin-Puplett spectrometers for astronomical observations at mm-wavelengths

The Martin-Puplett interferometer (MPI) is a differential Fourier transform spectrometer (FTS), measuring the difference between spectral brightness at two input ports. This unique feature makes the MPI an optimal zero instrument, able to detect small brightness gradients embeddend in a large common background. In this paper we investigate experimentally the common-mode rejection achievable in the MPI at mm wavelengths, and discuss the use of the instrument to measure the spectrum of cosmic microwave background (CMB) anisotropy

Quantifying the thermal Sunyaev–Zel’dovich effect and excess millimetre emission in quasar environments

In this paper, we probe the hot, post-shock gas component of quasar-driven winds through the thermal Sunyaev–Zel’dovich (tSZ) effect. Combining data sets from the Atacama Cosmology Telescope, the Herschel Space Observatory, and the Very Large Array, we measure average spectral energy distributions of 109 829 optically selected, radio quiet quasars from 1.4 to 3000 GHz in six redshift bins between 0.3 1.91, we measure the tSZ effect at 3.8σ significance with an amplitude corresponding to a total thermal energy of 3.1 × 10⁶⁰ erg. If this energy is due to virialized gas, then our measurement implies quasar host halo masses are ∼6 × 10¹² h⁻¹ M⊙. Alternatively, if the host dark matter halo masses are ∼2 × 10¹² h⁻¹ M⊙ as some measurements suggest, then we measure a >90 per cent excess in the thermal energy over that expected due to virialization. If the measured SZ effect is primarily due to hot bubbles from quasar-driven winds, we find that (5^(+1.2)_(−1.3) per cent of the quasar bolometric luminosity couples to the intergalactic medium over a fiducial quasar lifetime of 100 Myr. An additional source of tSZ may be correlated structure, and further work is required to separate the contributions. At z ≤ 1.91, we detect emission at 95 and 148 GHz that is in excess of thermal dust and optically thin synchrotron emission. We investigate potential sources of this excess emission, finding that CO line emission and an additional optically thick synchrotron component are the most viable candidates

Primordial Non-Gaussianity

Our current understanding of the Universe is established through the pristine measurements of structure in the cosmic microwave background (CMB) and the distribution and shapes of galaxies tracing the large scale structure (LSS) of the Universe. One key ingredient that underlies cosmological observables is that the field that sources the observed structure is assumed to be initially Gaussian with high precision. Nevertheless, a minimal deviation from Gaussianityis perhaps the most robust theoretical prediction of models that explain the observed Universe; itis necessarily present even in the simplest scenarios. In addition, most inflationary models produce far higher levels of non-Gaussianity. Since non-Gaussianity directly probes the dynamics in the early Universe, a detection would present a monumental discovery in cosmology, providing clues about physics at energy scales as high as the GUT scale

Efficient Differential Fourier-Transform Spectrometer for precision Sunyaev-Zel'dovich effect measurements

Precision measurements of the Sunyaev-Zel'dovich effect in clusters of galaxies require excellent rejection of common-mode signals and wide frequency coverage. We describe an imaging, efficient, differential Fourier transform spectrometer (FTS), optimized for measurements of faint brightness gradients at millimeter wavelengths. Our instrument is based on a Martin-Puplett interferometer (MPI) configuration. We combined two MPIs working synchronously to use the whole input power. In our implementation the observed sky field is divided into two halves along the meridian, and each half-field corresponds to one of the two input ports of the MPI. In this way, each detector in the FTS focal planes measures the difference in brightness between two sky pixels, symmetrically located with respect to the meridian. Exploiting the high common-mode rejection of the MPI, we can measure low sky brightness gradients over a high isotropic background. The instrument works in the range $\sim$ 1$-$20 cm$^{-1}$ (30$-$600 GHz), has a maximum spectral resolution $1/(2 \ OPD) = 0.063 \ cm^{-1}$ (1.9 GHz), and an unvignetted throughput of 2.3 cm$^2$sr. It occupies a volume of 0.7$\times$0.7$\times$0.33 m$^3$ and has a weight of 70 kg. This design can be implemented as a cryogenic unit to be used in space, as well as a room-temperature unit working at the focus of suborbital and ground-based mm-wave telescopes. The first in-flight test of the instrument is with the OLIMPO experiment on a stratospheric balloon; a larger implementation is being prepared for the Sardinia radio telescope.Comment: this version matches the published pape

[99mTc]Sestamibi SPECT can predict proliferation Index, angiogenesis, and vascular invasion in parathyroid patients: a retrospective study

The aim of this study was to evaluate the possible association among sestamibi uptake and the main histopathological characteristics of parathyroid lesions related to aggressiveness such as the proliferation index (Ki67 expression and mitosis), angiogenesis (number of vessels), and vascular invasion in hyperparathyroidism patients. To this end, 26 patients affected by primary hyperparathyroidism subjected to both scintigraphy with [(99)mTc]Sestamibi and surgery/bioptic procedure were retrospectively enrolled. Hyperfunctioning of the parathyroid was detected in 19 patients. Our data showed a significant positive association among the sestamibi uptake and the proliferation index histologically evaluated both in terms of the number of Ki67 positive cells and mitosis. According to these data, lesions with a higher valuer of L/N (lesion to nonlesion ratio) frequently showed several vessels in tumor areas and histological evidence of vascular invasion. It is noteworthy that among patients with negative scintigraphy, 2 patients showed a neoplastic lesion after surgery (histological analysis). However, it is important to highlight that these lesions displayed very low proliferation indexes, which was evaluated in terms of number of both mitosis and Ki67-positive cells, some/rare vessels in the main lesion, and no evidence of vascular invasion. In conclusion, data obtained on patients with positive or negative scintigraphy support the hypothesis that sestamibi can be a tracer that is capable of predicting some biological characteristics of parathyroid tumors such as angiogenesis, proliferation indexes, and the invasion of surrounding tissues or vessels

CMB-S4 Decadal Survey APC White Paper

We provide an overview of the science case, instrument configuration and project plan for the next-generation ground-based cosmic microwave background experiment CMB-S4, for consideration by the 2020 Decadal Survey