Field Programmable Gate Array

In this chapter, we describe the design of a field programmable gate array (FPGA) board capable of acquiring the information coming from a fast digitization of the signals generated in a drift chambers. The digitized signals are analyzed using an ad hoc real‐time algorithm implemented in the FPGA in order to reduce the data throughput coming from the particle detector

The Use of FPGA in Drift Chambers for High Energy Physics Experiments

In this chapter, we describe the design of a field programmable gate array (FPGA) board capable of acquiring the information coming from a fast digitization of the signals generated in a drift chambers. The digitized signals are analyzed using an ad hoc real‐time algorithm implemented in the FPGA in order to reduce the data throughput coming from the particle detector

Infantile Brain Tumors: A Review of Literature and Future Perspectives

Brain tumors in infants including those diagnosed in fetal age, newborns and under a year old represent less than 10% of pediatric nervous system tumors and present differently when compared with older children in terms of clinical traits, location and histology. The most frequent clinical finding is a macrocephaly but non-specific symptoms can also be associated. The prognosis is usually poor and depends on several factors. Surgery continues to be the main option in terms of therapeutic strategies whereas the role of chemotherapy is not yet well defined and radiotherapy is exceptionally undertaken. In view of this situation, a molecular characterization could assist in providing therapeutic options for these tumors. This review highlights the recent advances in the diagnosis and treatment of brain tumors in infants with a particular focus on the molecular landscape and future clinical applications

The use of FPGA in drift chambers for High Energy Physics experiments

In this chapter we describe the design of a Field Programmable Gate Array (FPGA) board capable of acquiring the information coming from a fast digitization of the signals generated in a drift chambers. The digitized signals are analyzed using an ad hoc real time algorithm implemented in the FPGA in order to reduce the data throughput coming from the particle detector

FOLFOX4 in the treatment of metastatic colorectal cancer in elderly patients: A prospective study

Elderly patients constitute a subpopulation with special characteristics that differ from those of the general population and have been under-represented in clinical trials. We, prospectively, analyzed the toxicity and efficacy of the original FOLFOX4-regimen in the treatment of elderly patients affected by metastatic (m) colorectal cancer (CRC). Thirty-six consecutive patients aged 67-82 years (median age 72 years), 22 males and 14 females, with mCRC and measurable disease, were enrolled in the study. The primary site of metastases was the liver (36.1% of patients). The median ECOG Performance Status (PS) was 1. The main hematological and extra-hematological (grade 3 or 4) toxicities were neutropenia (38.9%) and neurological (13.9%), respectively. A total of 36 patients, aged 67-82 years were included. Twenty-two and 14 patients were male and female, respectively. The median age was 72 years (range 67-82). The primary site of metastases was the liver (36.1% of patients). The median ECOG Performance Status (PS) was 1. The overall response rate (ORR) was 44.4% and similar to original study. Median progression-free survival (PFS) was 7.5 months and median overall survival (OS) was 16 months. The main hematological and extra-hematological (grade 3 or 4) toxicities were neutropenia (38.9%) and neurological (13.9%), respectively. Tolerability, however, was manageable and no toxic death occurred. FOLFOX4-regimen maintains its efficacy, and safety ratio in elderly patients with mCRC and good performance status. It would be considered the treatment of choice in the treatment of this particular setting of patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved

The Pierre Auger Observatory: Contributions to the 33rd International Cosmic Ray Conference (ICRC 2013)

Contributions of the Pierre Auger Collaboration to the 33rd International Cosmic Ray Conference, Rio de Janeiro, Brazil, July 201