Environmental changes during the MIS 6a–MIS 5e transition : the Parchliny 2016 profile, central Poland

We describe the penultimate glacial – last interglacial transition from the one of the numerous palaeolake successions in central Poland, which have yielded many documented Eemian and Early Weichselian floral records. In the new profile, Parchliny 2016, the lacustrine deposits were analysed lithologically, botanically, zoologically, and geochemically, providing new data that illustrate the environmental transition from the Late Saalian (MIS 6a) to the Eemian interglacial (MIS 5e). Five phases of palaeolake development have been distinguished. The first phase was related to the rapid melting of a dead ice block buried in the tills to form a lake. The second phase documented a Late Saalian initial succession, with the dominance of open steppe communities (Stadial 1), followed by a third phase with gradual increasing density of vegetation, the spread of boreal forests (Zeifen interstadial) and further increase in open communities and the retreat of pine (Kattegat stadial). The fourth phase reflected the beginning of Eemian interglacial by the expansion of pioneering birch-pine and purely birch forests and an increasing proportion of deciduous trees, including oak (Vth phase). Diatom, cladoceran and geochemical studies indicate at least two stages of lake development. The first stage (Late Saalian) was of an open lake (2–4 m deep), in relatively cold conditions and nutrient-poor water with the lowest amounts of organic carbon and nitrogen. The second stage (Eemian interglacial), shows warmer, shallower conditions in which the lake’s primary production increased, the water was well oxygenated, and there were more trophic levels

The Prognostic Value of Whole-Blood PSMB5, CXCR4, POMP, and RPL5 mRNA Expression in Patients with Multiple Myeloma Treated with Bortezomib

Proteasome inhibitors, like bortezomib, play a key role in the treatment of multiple myeloma (MM); however, most patients eventually relapse and eventually show multiple drug resistance, and the molecular mechanisms of this resistance remain unclear. The aim of our study is to assess the expression of previously described genes that may influence the resistance to bortezomib treatment at the mRNA level (ABCB1, CXCR4, MAF, MARCKS, POMP, PSMB5, RPL5, TXN, and XBP1) and prognosis of MM patients. mRNA expression was determined in 73 MM patients treated with bortezomib-based regimens (30 bortzomib-sensitive and 43 bortezomib-refractory patients) and 11 healthy controls. RPL5 was significantly down-regulated in multiple myeloma patients as compared with healthy controls. Moreover, POMP was significantly up-regulated in MM patients refractory to bortezomib-based treatment. In multivariate analysis, high expression of PSMB5 and CXCR and autologous stem cell transplantation were independent predictors of progression-free survival, and high expression of POMP and RPL5 was associated with shorter overall survival