8 research outputs found

    Regulators of the Actin Cytoskeleton Mediate Lethality in a Caenorhabditis elegans dhc-1 Mutant

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    Both LIS-1 and the dynein heavy-chain DHC-1 are required for integrity of the actin cytoskeleton in Caenorhabditis elegans. An RNAi screen revealed that knockdown of other actin regulators, including actin-capping protein genes and prefoldin subunit genes, suppresses dhc-1(or195ts)–induced lethality
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