8 research outputs found
Regulators of the Actin Cytoskeleton Mediate Lethality in a Caenorhabditis elegans dhc-1 Mutant
Both LIS-1 and the dynein heavy-chain DHC-1 are required for integrity of the actin cytoskeleton in Caenorhabditis elegans. An RNAi screen revealed that knockdown of other actin regulators, including actin-capping protein genes and prefoldin subunit genes, suppresses dhc-1(or195ts)–induced lethality