Informe sobre supervisión educativa en Paraguay

La supervisión Educativa en Paraguay, es ejercida por Supervisores/as de Control y Apoyo Administrativo y Supervisores/as de Apoyo Técnico Pedagógico, sus funciones abarcan los sectores públicos y privados así como el ámbito escolar y extraescolar de todos los niveles y programas

Centro de Difusión e Interpretación Cultural para el Visitante en el Valle de Chilina Mirador de Carmen Alto Arequipa

Este proyecto tiene la finalidad de fomentar e incrementar el turismo en la zona de Carmen Alto – Cayma, aumentando su importancia dentro del circuito turístico de Arequipa. Informamos al visitante a rescatar y mejorar la zona a través de la enseñanza y la contemplación, buscando revelar el significado del legado cultural e histórico de los bienes que se expone. Es importante generar identidad y mostrar a todos los usuarios, especialmente a los más pequeños el valor tan grande que alberga la zona como parte de nuestra cultura. Al enfocar dicho centro de interpretación para personas de distintas edades, la arquitectura se vuelve confortable y fluye de principio a fin, recorridos limpios, atractivos, buena iluminación y ventilación que van generando distintas sensaciones en los visitantes a través del recorrido. Los principios constructivos del Centro de Interpretación nos ayudan a conservar el entorno inmediato, pues nos encontramos en una zona de reglamentación especial, por lo tanto los materiales utilizados se mimetizan con el espacio natural. Actualmente el desencuentro urbano-natural, no permite la mejora del valle de Chilina, por lo que el mirador de Carmen Alto tiene una permanencia pasajera y no fija. El proyecto como generador de actividades nuevas, permitirá la suficiente permanencia del visitante para conocer la historia y evolución del valle de Chilina, valorar y respetar la cultura, tradición, flora y fauna, generar ingresos y oportunidades de trabajo para jóvenes y adultos. Palabras Claves: Centro de difusión - Centro de Interpretación – Desencuentro Urbano Natural – Mirador - Carmen Alto – Valle de Chilina – Circuito turístico – IdentidadTesi

Occurrence of tetrodotoxin in bivalves and gastropods from harvesting areas and other natural spaces in Spain

Tetrodotoxin (TTX) is a potent neurotoxin that is receiving increasing interest in the European Union because it has been found in different fishery products (fish, bivalves and gastropods) captured in European waters. Since available information is scarce, further analytical data regarding the incidence of this toxin in European fishery products is needed in order to perform an appropriate risk assessment devoted to protecting consumers’ health. Hence, samples of bivalves and gastropods were collected at different points of the Spanish coast and analyzed by high-performance hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS) to evaluate the presence of TTX. None of the analyzed samples showed TTX above an internal threshold of 10 µg/kg or even showed a peak under it. Our results on TTX occurrence obtained in bivalve molluscs and gastropods did not show, at least in the studied areas, a risk for public health. However, taking into account previous positive results obtained by other research groups, and since we did not detect TTX in our samples, a more completed study increasing sampling frequency is needed to ensure proper risk evaluation towards the food safety of these products.info:eu-repo/semantics/publishedVersio

Seminal plasma proteins modify the distribution of sperm subpopulations in cryopreserved semen of rams with lesser fertility

P. 44-50Any physiological mechanism involved in sperm selection and semen improvement has effects on heterogeneous sperm populations. This is mainly due to the fact that sperm populations within a single ejaculate have considerable heterogeneity for many variables, such as motility which is meaningful in terms of understanding how some sperm cells possess fertility advantages as compared with other cells. In the present research, initially there was a multivariate and clustering analysis used to assess sperm motility data from cryopreserved ram semen to identify subpopulations and compare the distribution of these clusters between rams with lesser and greater fertility. There were four classifications made of sperm subpopulations (clusters): CL1 fast/linear/progressive sperm; CL2 fast/non-linear sperm; CL3 very fast/linear sperm with vigorous beating and CL4 slow/non-linear sperm. Rams with greater fertility had a lesser proportion of sperm considered as “hyperactivated” (CL2) and a greater proportion of slow and non-linear sperm (CL4) than sperm of rams with lesser fertility. In addition, the effects were assessed for the capacity of seminal plasma (SP) and interacting SP proteins (iSPP) that were present during different seasons of the year to improve the distribution of sperm within subpopulations of semen from rams with lesser fertility. The iSPP and SP were obtained by artificial vagina (AV) and electroejaculation (EE) during breeding and non-breeding seasons and added to thawed semen. All the aggregates had a significant effect on the distribution of sperm subpopulations and effects differed among seasons of the year and depending on collection method used. Even though, future studies are needed to assess the contribution of each subpopulation on ram sperm fertility, it is important that a multivariate analysis be used to evaluate the effect of a treatment on sperm quality variables.S

Novel and conventional embryo parameters as input data for artificial neural networks: an artificial intelligence model applied for prediction of the implantation potential

[ES] Objetivo: Describir nuevas características de embriones capaces de predecir el potencial de implantación como datos de entrada para un modelo de red neuronal artificial (ANN). Diseño: Estudio de cohorte retrospectivo. Entorno: Centro de FIV privado afiliado a la universidad. Paciente (s): Este estudio incluyó a 637 pacientes del programa de donación de ovocitos que se sometieron a transferencia de un solo blastocisto durante dos años consecutivos. Intervención (es): Ninguna. Principales medidas de resultado: La investigación se dividió en dos fases. La fase 1 consistió en la descripción y análisis de las siguientes características embrionarias en embriones implantados y no implantados: distancia y velocidad de migración pronuclear, diámetro del blastocisto expandido, área de masa celular interna y duración del ciclo celular del trofoectodermo. La fase 2 consistió en el desarrollo de un algoritmo ANN para la predicción de la implantación. Se obtuvieron resultados para cuatro modelos alimentados con diferentes datos de entrada. El poder predictivo se midió con el uso del área bajo la curva característica operativa del receptor (AUC). Resultado (s): De los cinco nuevos parámetros descritos, el diámetro expandido del blastocisto y la duración del ciclo celular del trofoectodermo tenían valores estadísticamente diferentes en los embriones implantados y no implantados. Después de que los modelos ANN fueron entrenados y validados mediante validación cruzada cinco veces, estos fueron capaces de predecir la implantación en los datos de prueba con AUC de 0,64 para ANN1 (morfocinética convencional), 0,73 para ANN2 (morfodinámica novedosa), 0,77 para ANN3 (morfocinética convencional þ morfodinámica novedosa) y 0,68 para ANN4 (variables discriminatorias de prueba estadística). Conclusión (es): Las nuevas características embrionarias propuestas afectan al potencial de implantación y su combinación con parámetros morfocinéticos convencionales es eficaz como datos de entrada para un modelo predictivo basado en inteligencia artificial.[EN] Objective: To describe novel embryo features capable of predicting implantation potential as input data for an artificial neural network (ANN) model. Design: Retrospective cohort study. Setting: University-affiliated private IVF center. Patient(s): This study included 637 patients from the oocyte donation program who underwent single-blastocyst transfer during two consecutive years. Intervention(s): None. Main Outcome Measure(s): The research was divided into two phases. Phase 1 consisted of the description and analysis of the following embryo features in implanted and nonimplanted embryos: distance and speed of pronuclear migration, blastocyst expanded diameter, inner cell mass area, and trophectoderm cell cycle length. Phase 2 consisted of the development of an ANN algorithm for implantation prediction. Results were obtained for four models fed with different input data. The predictive power was measured with the use of the area under the receiver operating characteristic curve (AUC). Result(s): Out of the five novel described parameters, blastocyst expanded diameter and trophectoderm cell cycle length had statistically different values in implanted and nonimplanted embryos. After the ANN models were trained and validated using fivefold cross validation, they were capable of predicting implantation on testing data with AUCs of 0.64 for ANN1 (conventional morphokinetics), 0.73 for ANN2 (novel morphodynamics), 0.77 for ANN3 (conventional morphokinetics thorn novel morphodynamics), and 0.68 for ANN4 (discriminatory variables from statistical test). Conclusion(s): The novel proposed embryo features affect the implantation potential, and their combination with conventional morphokinetic parameters is effective as input data for a predictive model based on artificial intelligence. ((c) 2020 by American Society for Reproductive Medicine.)Supported by the Ministry of Science, Innovation, and Universities CDTI (IDI-20191102), an Industrial Ph.D. grant (DIN2018-009911), and Agencia Valenciana de Innovacio (INNCAD00-18-009) to E.P. and M.M.Bori, L.; Paya-Bosch, E.; Alegre, L.; Viloria, T.; Remohí, J.; Naranjo Ornedo, V.; Meseguer, M. (2020). Novel and conventional embryo parameters as input data for artificial neural networks: an artificial intelligence model applied for prediction of the implantation potential. Fertility and Sterility. 114(6):1232-1241. https://doi.org/10.1016/j.fertnstert.2020.08.023S123212411146De Geyter, C., Calhaz-Jorge, C., Kupka, M. S., Wyns, C., Mocanu, E., Motrenko, T., … Goossens, V. (2018). ART in Europe, 2014: results generated from European registries by ESHRE†. Human Reproduction, 33(9), 1586-1601. doi:10.1093/humrep/dey242Edwards, R. G., Fishel, S. B., Cohen, J., Fehilly, C. B., Purdy, J. M., Slater, J. M., … Webster, J. M. (1984). Factors influencing the success of in vitro fertilization for alleviating human infertility. Journal of In Vitro Fertilization and Embryo Transfer, 1(1), 3-23. doi:10.1007/bf01129615Ferraretti, A. P., Goossens, V., de Mouzon, J., Bhattacharya, S., Castilla, J. A., … Korsak, V. (2012). Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE†. Human Reproduction, 27(9), 2571-2584. doi:10.1093/humrep/des255Zhang, J. Q., Li, X. L., Peng, Y., Guo, X., Heng, B. C., & Tong, G. Q. (2010). Reduction in exposure of human embryos outside the incubator enhances embryo quality and blastulation rate. Reproductive BioMedicine Online, 20(4), 510-515. doi:10.1016/j.rbmo.2009.12.027Cruz, M., Garrido, N., Herrero, J., Pérez-Cano, I., Muñoz, M., & Meseguer, M. (2012). Timing of cell division in human cleavage-stage embryos is linked with blastocyst formation and quality. Reproductive BioMedicine Online, 25(4), 371-381. doi:10.1016/j.rbmo.2012.06.017Kirkegaard, K., Agerholm, I. E., & Ingerslev, H. J. (2012). Time-lapse monitoring as a tool for clinical embryo assessment. Human Reproduction, 27(5), 1277-1285. doi:10.1093/humrep/des079Montag, M., Liebenthron, J., & Köster, M. (2011). Which morphological scoring system is relevant in human embryo development? Placenta, 32, S252-S256. doi:10.1016/j.placenta.2011.07.009Aparicio, B., Cruz, M., & Meseguer, M. (2013). Is morphokinetic analysis the answer? Reproductive BioMedicine Online, 27(6), 654-663. doi:10.1016/j.rbmo.2013.07.017Gallego, R. D., Remohí, J., & Meseguer, M. (2019). Time-lapse imaging: the state of the art†. Biology of Reproduction, 101(6), 1146-1154. doi:10.1093/biolre/ioz035Zaninovic, N., Irani, M., & Meseguer, M. (2017). Assessment of embryo morphology and developmental dynamics by time-lapse microscopy: is there a relation to implantation and ploidy? Fertility and Sterility, 108(5), 722-729. doi:10.1016/j.fertnstert.2017.10.002Athayde Wirka, K., Chen, A. A., Conaghan, J., Ivani, K., Gvakharia, M., Behr, B., … Shen, S. (2014). Atypical embryo phenotypes identified by time-lapse microscopy: high prevalence and association with embryo development. Fertility and Sterility, 101(6), 1637-1648.e5. doi:10.1016/j.fertnstert.2014.02.050Zhan, Q., Ye, Z., Clarke, R., Rosenwaks, Z., & Zaninovic, N. (2016). Direct Unequal Cleavages: Embryo Developmental Competence, Genetic Constitution and Clinical Outcome. PLOS ONE, 11(12), e0166398. doi:10.1371/journal.pone.0166398Goodman, L. R., Goldberg, J., Falcone, T., Austin, C., & Desai, N. (2016). Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial. Fertility and Sterility, 105(2), 275-285.e10. doi:10.1016/j.fertnstert.2015.10.013Desai, N., Ploskonka, S., Goodman, L., Attaran, M., Goldberg, J. M., Austin, C., & Falcone, T. (2016). Delayed blastulation, multinucleation, and expansion grade are independently associated with live-birth rates in frozen blastocyst transfer cycles. Fertility and Sterility, 106(6), 1370-1378. doi:10.1016/j.fertnstert.2016.07.1095Aguilar, J., Rubio, I., Muñoz, E., Pellicer, A., & Meseguer, M. (2016). Study of nucleation status in the second cell cycle of human embryo and its impact on implantation rate. Fertility and Sterility, 106(2), 291-299.e2. doi:10.1016/j.fertnstert.2016.03.036Rubio, I., Kuhlmann, R., Agerholm, I., Kirk, J., Herrero, J., Escribá, M.-J., … Meseguer, M. (2012). Limited implantation success of direct-cleaved human zygotes: a time-lapse study. Fertility and Sterility, 98(6), 1458-1463. doi:10.1016/j.fertnstert.2012.07.1135Desai, N., Ploskonka, S., Goodman, L. R., Austin, C., Goldberg, J., & Falcone, T. (2014). Analysis of embryo morphokinetics, multinucleation and cleavage anomalies using continuous time-lapse monitoring in blastocyst transfer cycles. Reproductive Biology and Endocrinology, 12(1), 54. doi:10.1186/1477-7827-12-54Ebner, T., Höggerl, A., Oppelt, P., Radler, E., Enzelsberger, S.-H., Mayer, R. B., … Shebl, O. (2017). Time-lapse imaging provides further evidence that planar arrangement of blastomeres is highly abnormal. Archives of Gynecology and Obstetrics, 296(6), 1199-1205. doi:10.1007/s00404-017-4531-5Azzarello, A., Hoest, T., Hay-Schmidt, A., & Mikkelsen, A. L. (2017). Live birth potential of good morphology and vitrified blastocysts presenting abnormal cell divisions. Reproductive Biology, 17(2), 144-150. doi:10.1016/j.repbio.2017.03.004Desch, L., Bruno, C., Luu, M., Barberet, J., Choux, C., Lamotte, M., … Fauque, P. (2017). Embryo multinucleation at the two-cell stage is an independent predictor of intracytoplasmic sperm injection outcomes. Fertility and Sterility, 107(1), 97-103.e4. doi:10.1016/j.fertnstert.2016.09.022Kirkegaard, K., Hindkjaer, J. J., Grøndahl, M. L., Kesmodel, U. S., & Ingerslev, H. J. (2012). A randomized clinical trial comparing embryo culture in a conventional incubator with a time-lapse incubator. Journal of Assisted Reproduction and Genetics, 29(6), 565-572. doi:10.1007/s10815-012-9750-xWong, C. C., Loewke, K. E., Bossert, N. L., Behr, B., De Jonge, C. J., Baer, T. M., & Pera, R. A. R. (2010). Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage. Nature Biotechnology, 28(10), 1115-1121. doi:10.1038/nbt.1686Conaghan, J., Chen, A. A., Willman, S. P., Ivani, K., Chenette, P. E., Boostanfar, R., … Shen, S. (2013). Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial. Fertility and Sterility, 100(2), 412-419.e5. doi:10.1016/j.fertnstert.2013.04.021Milewski, R., Kuć, P., Kuczyńska, A., Stankiewicz, B., Łukaszuk, K., & Kuczyński, W. (2015). A predictive model for blastocyst formation based on morphokinetic parameters in time-lapse monitoring of embryo development. Journal of Assisted Reproduction and Genetics, 32(4), 571-579. doi:10.1007/s10815-015-0440-3Chamayou, S., Patrizio, P., Storaci, G., Tomaselli, V., Alecci, C., Ragolia, C., … Guglielmino, A. (2013). The use of morphokinetic parameters to select all embryos with full capacity to implant. Journal of Assisted Reproduction and Genetics, 30(5), 703-710. doi:10.1007/s10815-013-9992-2Milewski, R., Czerniecki, J., Kuczyńska, A., Stankiewicz, B., & Kuczyński, W. (2016). Morphokinetic parameters as a source of information concerning embryo developmental and implantation potential. Ginekologia Polska, 87(10), 677-684. doi:10.5603/gp.2016.0067Motato, Y., de los Santos, M. J., Escriba, M. J., Ruiz, B. A., Remohí, J., & Meseguer, M. (2016). Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system. Fertility and Sterility, 105(2), 376-384.e9. doi:10.1016/j.fertnstert.2015.11.001Petersen, B. M., Boel, M., Montag, M., & Gardner, D. K. (2016). Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3. Human Reproduction, 31(10), 2231-2244. doi:10.1093/humrep/dew188Meseguer, M., Herrero, J., Tejera, A., Hilligsoe, K. M., Ramsing, N. B., & Remohi, J. (2011). The use of morphokinetics as a predictor of embryo implantation. Human Reproduction, 26(10), 2658-2671. doi:10.1093/humrep/der256Liu, Y., Chapple, V., Feenan, K., Roberts, P., & Matson, P. (2016). Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth. Fertility and Sterility, 105(3), 656-662.e1. doi:10.1016/j.fertnstert.2015.11.003VerMilyea, M. D., Tan, L., Anthony, J. T., Conaghan, J., Ivani, K., Gvakharia, M., … Shen, S. (2014). Computer-automated time-lapse analysis results correlate with embryo implantation and clinical pregnancy: A blinded, multi-centre study. Reproductive BioMedicine Online, 29(6), 729-736. doi:10.1016/j.rbmo.2014.09.005Basile, N., Vime, P., Florensa, M., Aparicio Ruiz, B., García Velasco, J. A., Remohí, J., & Meseguer, M. (2014). The use of morphokinetics as a predictor of  implantation: a multicentric study to define and validate an algorithm for embryo selection. Human Reproduction, 30(2), 276-283. doi:10.1093/humrep/deu331Aparicio-Ruiz, B., Romany, L., & Meseguer, M. (2018). Selection of preimplantation embryos using time-lapse microscopy in in vitro fertilization: State of the technology and future directions. Birth Defects Research, 110(8), 648-653. doi:10.1002/bdr2.1226Barrie, A., Homburg, R., McDowell, G., Brown, J., Kingsland, C., & Troup, S. (2017). Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging. Reproductive BioMedicine Online, 34(5), 455-462. doi:10.1016/j.rbmo.2017.02.011Campbell, A., Fishel, S., Bowman, N., Duffy, S., Sedler, M., & Hickman, C. F. L. (2013). Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics. Reproductive BioMedicine Online, 26(5), 477-485. doi:10.1016/j.rbmo.2013.02.006Desai, N., Goldberg, J. M., Austin, C., & Falcone, T. (2018). Are cleavage anomalies, multinucleation, or specific cell cycle kinetics observed with time-lapse imaging predictive of embryo developmental capacity or ploidy? Fertility and Sterility, 109(4), 665-674. doi:10.1016/j.fertnstert.2017.12.025Amir, H., Barbash-Hazan, S., Kalma, Y., Frumkin, T., Malcov, M., Samara, N., … Ben-Yosef, D. (2018). Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations. Journal of Assisted Reproduction and Genetics, 36(2), 315-324. doi:10.1007/s10815-018-1361-8Del Carmen Nogales, M., Bronet, F., Basile, N., Martínez, E. M., Liñán, A., Rodrigo, L., & Meseguer, M. (2017). Type of chromosome abnormality affects embryo morphology dynamics. Fertility and Sterility, 107(1), 229-235.e2. doi:10.1016/j.fertnstert.2016.09.019Dyer, S., Chambers, G. M., de Mouzon, J., Nygren, K. G., Zegers-Hochschild, F., Mansour, R., … Adamson, G. D. (2016). International Committee for Monitoring Assisted Reproductive Technologies world report: Assisted Reproductive Technology 2008, 2009 and 2010. Human Reproduction, 31(7), 1588-1609. doi:10.1093/humrep/dew082Simopoulou, M., Sfakianoudis, K., Maziotis, E., Antoniou, N., Rapani, A., Anifandis, G., … Koutsilieris, M. (2018). Are computational applications the «crystal ball» in the IVF laboratory? The evolution from mathematics to artificial intelligence. Journal of Assisted Reproduction and Genetics, 35(9), 1545-1557. doi:10.1007/s10815-018-1266-6Milewski, R., Kuczyńska, A., Stankiewicz, B., & Kuczyński, W. (2017). How much information about embryo implantation potential is included in morphokinetic data? A prediction model based on artificial neural networks and principal component analysis. Advances in Medical Sciences, 62(1), 202-206. doi:10.1016/j.advms.2017.02.001Curchoe, C. L., & Bormann, C. L. (2019). Artificial intelligence and machine learning for human reproduction and embryology presented at ASRM and ESHRE 2018. Journal of Assisted Reproduction and Genetics, 36(4), 591-600. doi:10.1007/s10815-019-01408-xTran, D., Cooke, S., Illingworth, P. J., & Gardner, D. K. (2019). Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer. Human Reproduction, 34(6), 1011-1018. doi:10.1093/humrep/dez064Khosravi, P., Kazemi, E., Zhan, Q., Malmsten, J. E., Toschi, M., Zisimopoulos, P., … Hajirasouliha, I. (2019). Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization. npj Digital Medicine, 2(1). doi:10.1038/s41746-019-0096-yCerrillo, M., Herrero, L., Guillén, A., Mayoral, M., & García-Velasco, J. A. (2017). Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates. Rambam Maimonides Medical Journal, 8(2), e0020. doi:10.5041/rmmj.10297Panchal, G., Ganatra, A., Kosta, Y. P., & Panchal, D. (2011). Behaviour Analysis of Multilayer Perceptronswith Multiple Hidden Neurons and Hidden Layers. International Journal of Computer Theory and Engineering, 332-337. doi:10.7763/ijcte.2011.v3.328Azzarello, A., Hoest, T., & Mikkelsen, A. L. (2012). The impact of pronuclei morphology and dynamicity on live birth outcome after time-lapse culture. Human Reproduction, 27(9), 2649-2657. doi:10.1093/humrep/des210Dal Canto, M., Coticchio, G., Mignini Renzini, M., De Ponti, E., Novara, P. V., Brambillasca, F., … Fadini, R. (2012). Cleavage kinetics analysis of human embryos predicts development to blastocyst and implantation. Reproductive BioMedicine Online, 25(5), 474-480. doi:10.1016/j.rbmo.2012.07.016Barrie, A., Homburg, R., McDowell, G., Brown, J., Kingsland, C., & Troup, S. (2017). Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms. Fertility and Sterility, 107(3), 613-621. doi:10.1016/j.fertnstert.2016.11.014Coticchio, G., Mignini Renzini, M., Novara, P. V., Lain, M., De Ponti, E., Turchi, D., … Dal Canto, M. (2017). Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability. Human Reproduction, 33(1), 23-31. doi:10.1093/humrep/dex344Aguilar, J., Motato, Y., Escribá, M. J., Ojeda, M., Muñoz, E., & Meseguer, M. (2014). The human first cell cycle: impact on implantation. Reproductive BioMedicine Online, 28(4), 475-484. doi:10.1016/j.rbmo.2013.11.014Barberet, J., Bruno, C., Valot, E., Antunes-Nunes, C., Jonval, L., Chammas, J., … Fauque, P. (2019). Can novel early non-invasive biomarkers of embryo quality be identified with time-lapse imaging to predict live birth? Human Reproduction, 34(8), 1439-1449. doi:10.1093/humrep/dez085Richter, K. S., Harris, D. C., Daneshmand, S. T., & Shapiro, B. S. (2001). Quantitative grading of a human blastocyst: optimal inner cell mass size and shape. Fertility and Sterility, 76(6), 1157-1167. doi:10.1016/s0015-0282(01)02870-9Shapiro, B. S., Daneshmand, S. T., Garner, F. C., Aguirre, M., & Thomas, S. (2008). Large blastocyst diameter, early blastulation, and low preovulatory serum progesterone are dominant predictors of clinical pregnancy in fresh autologous cycles. Fertility and Sterility, 90(2), 302-309. doi:10.1016/j.fertnstert.2007.06.062Almagor, M., Harir, Y., Fieldust, S., Or, Y., & Shoham, Z. (2016). Ratio between inner cell mass diameter and blastocyst diameter is correlated with successful pregnancy outcomes of single blastocyst transfers. Fertility and Sterility, 106(6), 1386-1391. doi:10.1016/j.fertnstert.2016.08.009Shapiro, B. S., Harris, D. C., & Richter, K. S. (2000). Predictive value of 72-hour blastomere cell number on blastocyst development and success of subsequent transfer based on the degree of blastocyst development. Fertility and Sterility, 73(3), 582-586. doi:10.1016/s0015-0282(99)00586-5Coello, A., Meseguer, M., Galán, A., Alegre, L., Remohí, J., & Cobo, A. (2017). Analysis of the morphological dynamics of blastocysts after vitrification/warming: defining new predictive variables of implantation. Fertility and Sterility, 108(4), 659-666.e4. doi:10.1016/j.fertnstert.2017.07.1157Huang, T. T., Huang, D. H., Ahn, H. J., Arnett, C., & Huang, C. T. (2019). Early blastocyst expansion in euploid and aneuploid human embryos: evidence for a non-invasive and quantitative marker for embryo selection. Reproductive BioMedicine Online, 39(1), 27-39. doi:10.1016/j.rbmo.2019.01.010Sundvall, L., Ingerslev, H. J., Breth Knudsen, U., & Kirkegaard, K. (2013). Inter- and intra-observer variability of time-lapse annotations. Human Reproduction, 28(12), 3215-3221. doi:10.1093/humrep/det36

Detoxification of paralytic shellfish poisoning toxins in naturally contaminated mussels, clams and scallops by an industrial procedure

Paralytic shellfish poisoning (PSP) episodes cause important economic impacts due to closure of shellfish production areas in order to protect human health. These closures, if are frequent and persistent, can seriously affect shellfish producers and the seafood industry, among others. In this study, we have developed an alternative processing method for bivalves with PSP content above the legal limit, which allows reducing toxicity to acceptable levels. A modification of the PSP detoxifying procedure stablished by Decision 96/77/EC of the European Union in Acanthocardia tuberculatum, was developed and implemented for PSP elimination in other bivalves species. The procedure was applied to 6 batches of mussels, 2 batches of clams and 2 batches of scallops, achieving detoxification rates of around 85%. A viable industrial protocol which allows the transformation of a product at risk into a safe product was developed. Although a significant reduction was obtained, in a sample circa 9000 μg STX diHCl equiv/kg, the final toxin level in these highly toxic mussels did not fall below the European limit. The processing protocol described may be applied efficiently to mussels, clams and scallops and it may be a major solution to counteract the closure of shellfish harvesting areas, especially if persistent.info:eu-repo/semantics/acceptedVersio

Estudio global de las empresas del Parque Industrial y Tecnológico Mar del Plata-Batán

Se presentan los principales resultados que surgen del relevamiento a 34 empresas radicadas en el Parque Industrial y Tecnológico Mar del Plata-Batán (PI), durante mayo-septiembre 2018.Fil: Graña, Fernando Manuel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Mauro, Lucía Mercedes. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Liseras, Natacha. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Gonzalez Barros, Ariel. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina.Fil: Alegre, Patricia. Universidad Nacional de Mar del Plata. Facultad de Ciencias Económicas y Sociales; Argentina

Open innovation and superior performance in SMEs: the mediating role of marketing capabilities and innovation

Even though many enterprises apply open innovation practices in the search for external sources of knowledge, this does not necessarily translate to improved performance. This issue is especially important for medium and small enterprises (SMEs) which need to expand their knowledge frontiers to survive and achieve superior performance. The objective of this research is to analyze the role of marketing capabilities and innovation in the relationship between open innovation and organizational performance. Using structural equation modeling, this research presents empirical evidence from 154 manufacturing SMEs. Research findings reveal that open innovation alone does not influence organizational performance, confirming that marketing capabilities and innovation play individual and sequential mediation roles in the relationship between open innovation and performance. From this, SME managers, in addition to looking for external knowledge, should develop marketing and innovation capabilities to capitalize this external knowledge and develop effective strategies to significantly impact performance

De lo real a lo imaginario : aproximación a la flora ibérica durante la Edad del Hierro

"De lo real a lo imaginario" es el título de un proyecto cuyo objetivo es hacer un estudio de la flora de los iberos desde distintos puntos de vista con el fin de aproximarnos al uso y simbolismo de las plantas por parte de las sociedades antiguas. Para ello se va a combinar una visión estrictamente paleobotánica, basada en estudios palinológicos, antracológicos y paleocarpológicos, con la iconográfica, recogiendo todas las representaciones de plantas que aparecen en cerámica, escultura en piedra, objetos metálicos y monedas. Todos los datos se catalogan teniendo en cuenta su contexto y cronología. Con ello se pretende elaborar un catálogo de plantas conocidas y utilizadas, en diferentes contextos, con todos los usos posibles (lo real) y las imágenes de plantas recogidas en diversos soportes (lo imaginario). Como ejemplo, se presenta el estudio realizado sobre dos plantas: la adormidera (Papaver sp.) y la palmera (Phoenix datylifera L.)."From the real to the imagery" is the translation of the project"s title we present in this paper. Our main goal is the study of the Iberian Iron Age fl ora from several points of view in order to come close to the use and the simbolism of plants among the ancient societies, specially the Iberian Culture. The method we use is a combination of a paleobotanical approach, based on palinology, anthracology and paleocarpology, together with an iconographic one. Then, we record all the representations of plants on pottery, stone sculpture, metallic objects and coins. All these data are catalogued taking in to account the context and chronology of the archaeological remains we are dealing with. The aim of this research project is to create a database of the used and known plants among the Iberians, to reconstruct the possible uses ("the real") and the images of plants represented on the artefacts ("the imagery"). This paper offers preliminary results of our method by presenting an analytical example based on two species: the poppy (Papaver sp.) and the palm tree (Phoenix datylifera L.)