Obesidad, autoestima y condición física en escolares

Introducción. La obesidad infantil es un problema grave de salud pública, ya que genera resultados adversos para la salud física y mental.Objetivo. Relacionar el estado nutricional con los niveles de autoestima y rendimiento físico en escolares de 8 a 10 años de edad.Materiales y métodos. Participaron 236 escolares: 117 hombres y 119 mujeres, de entre 8 y 10 años de edad, pertenecientes a dos colegios del municipio de Temuco con carácter estatal-municipal. Se evaluó peso, talla, índice de masa corporal, porcentaje de masa/grasa, contorno cintura, condición física, horas de ejercicio físico a la semana y autoestima.Resultados. El 43.6% de los escolares presentó malnutrición por exceso. Los categorizados como obesos (19%) presentaron niveles superiores en masa grasa y contorno cintura (p0.001), además obtuvieron un rendimiento físico menor (p0.05). Las horas realizadas de ejercicio físico a la semana y el nivel de autoestima fueron menores en lo escolares obesos, pero estos no alcanzaron significancia (p≥ 0.05).Conclusiones. La obesidad en edad escolar pone de manifiesto alteraciones asociadas con el rendimiento físico, la masa grasa y las tendencias negativas sobre la autoestima. A pesar de ser una etapa temprana, se pueden apreciar las consecuencias asociadas a esta condición.Introduction: Childhood obesity is a serious public health issue, since it generates adverse results for physical and mental health.Objective: To correlate nutritional status and levels of self-esteem and physical performance in schoolchildren aged between 8 and 10.Materials and methods: 236 students participated, 117 male and 119 female, aged between 8 and 10, from two public schools in the municipality of Temuco. Weight, height, body mass index, mass/fat percentage, waist contour, physical condition, hours of physical exercise per week and self-esteem were evaluated.Results: Overnutrition was documented in 43.6% of the students; children classified as obese (19%) presented higher levels of fat mass and waist contour (p0.001), and also had a lower physical performance (p0.05). The hours of physical exercise per week and the level of self-esteem were lower in obese school children, although this figure was not significant (p≥0.05).Conclusions: Obesity in school-aged children reveals alterations associated with physical performance, fat mass and negative trends on self-esteem. Despite developing at an early stage, the consequences associated with this condition can already be seen

Talento de los estudiantes de ingeniería para emprender actividades de negocio

Objetivo: Analizar el Talento Cognitivo de los Estudiantes de Ingeniería y su relación con la Experiencia en Algún Negocio. Métodos: Se aplico el método deductivo e inductivo. Se utilizó el modelo del diseño de investigación descriptivo correlacional. La población del estudio fue de 1422 estudiantes de la Facultad de Ingeniería Industrial, Sistemas e Informática, del que se calculó un tamaño de muestra final de 250 estudiantes. Resultados: A nivel descriptivo sobre la primera variable denominada el Talento Cognitivo de los estudiantes, se consideró los factores como: Conocimientos en Economía, Conocimientos en Negocios y Conocimientos en Gestión; los resultados indican que tienen niveles Básicos de Conocimientos, representando a la mayoría con un porcentaje del 58,8%. Sobre la segunda variable denominada Experiencia en Algún Negocio, los resultados muestran que son las Ventas las experiencias más comunes representados con un porcentaje del 56,0%. A nivel inferencial, las pruebas de hipótesis para cada factor arrojaron una significación de muestra de 0,000, menor al 0,05 probabilistico, lo que confirma los planteamientos iniciales. Conclusiones: A la luz de los resultados se comprueba que existen factores cognitivos que predisponen a los estudiantes de ingeniería para emprender actividades de negocios. Estos resultados nos revela la oportunidad que debe de aprovecharse para fortalecer los conocimientos de los estudiantes de ingeniería en el mundo de los negocio a nivel formal, de tal manera que se contribuya en nuestra comunidad con el desarrollo de la economía local y nacional. Palabras clave: Talento, conocimientos, economía, negocio, gestión, ventas, servicios, producció

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Ampliación de la distribución geográfica de Basiliscus vittatus en el estado de Puebla Extension of geographical distribution of Basiliscus vittatus in the state of Puebla

Se registró una hembra de Basiliscus vittatus a orilla del río Mezonate en el municipio de Tenampulco de la sierra Norte de Puebla. Éste es el segundo registro de la especie en el estado, pero en una provincia fisiográfica distinta, con el cual se amplía el área de distribución para el estado.<br>We registered one female Basiliscus vittatus on the banks of the river Mezonate in the Municipality of Tenampulco in the Sierra Norte de Puebla. This is the second record for this species in the state but in two different physiographic provinces and extends the area distribution for the state

Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.

The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually expressed in C9 cells and their signaling and regulation were studied. Agonist-activation increases intracellular calcium concentration in a concentration-dependent fashion. Phorbol myristate acetate markedly inhibited LPA1- and LPA3-mediated effect, whereas that mediated by LPA2 was only partially diminished; the actions of the phorbol ester were inhibited by bisindolylmaleimide I and by overnight incubation with the protein kinase C activator, which leads to down regulation of this protein kinase. Homologous desensitization was also observed for the three LPA receptors studied, with that of LPA2 receptors being consistently of lesser magnitude; neither inhibition nor down-regulation of protein kinase C exerted any effect on homologous desensitization. Activation of LPA1-3 receptors induced ERK 1/2 phosphorylation; this effect was markedly attenuated by inhibition of epidermal growth factor receptor tyrosine kinase activity, suggesting growth factor receptor transactivation in this effect. Lysophosphatidic acid and phorbol myristate acetate were able to induce LPA1-3 phosphorylation, in time- and concentration-dependent fashions. It was also clearly observed that agonists and protein kinase C activation induced internalization of these receptors. Phosphorylation of the LPA2 subtype required larger concentrations of these agents and its internalization was less intense than that of the other subtypes.Our data show that these three LPA receptors are phosphoproteins whose phosphorylation state is modulated by agonist-stimulation and protein kinase C-activation and that differences in regulation and cellular localization exist, among the subtypes

The Protein quality control system manages plant defence compound synthesis

Jasmonates are ubiquitous oxylipin-derived phytohormones that are essential in the regulation of many development, growth and defence processes. Across the plant kingdom, jasmonates act as elicitors of the production of bioactive secondarymetabolites that serve in defence against attackers. Knowledge of the conserved jasmonate perception and early signalling machineries is increasing, but the downstream mechanisms that regulate defence metabolism remain largely unknown. Herewe showthat, in the legumeMedicago truncatula, jasmonate recruits the endoplasmic-reticulum-associated degradation (ERAD)quality control system tomanagethe production of triterpene saponins, widespread bioactive compounds that share a biogenic origin with sterols. An ERAD-type RING membraneanchor E3 ubiquitin ligase is co-expressed with saponin synthesis enzymes to control the activity of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the rate-limiting enzyme in the supply of the ubiquitous terpene precursor isopentenyl diphosphate. Thus, unrestrained bioactive saponin accumulationis prevented and plant development and integrity secured. This control apparatus is equivalent to the ERAD system that regulates sterol synthesis in yeasts and mammals but that uses distinct E3 ubiquitin ligases, of the HMGR degradation 1 (HRD1) type, to direct destruction of HMGR. Hence, the general principles for the management of sterol and triterpene saponin biosynthesis are conserved across eukaryotes but can be controlled by divergent regulatory cues