RESEARCH ON PLATING PARTS USED IN THE OIL INDUSTRY

The paper includes a number of theoretical and experimental results on plating of several pieces from different classes focusing especially on the pieces of the flanges and housings class. For reasons of confidentiality to beneficiaries, the paper presents experimeindustry at the ends of probe drilling and extraction. Have been taken into account these kinds of pieces in the research due to operating conditions and high requests which occur during operation

Caveolin-1-Knockout Mouse as a Model of Inflammatory Diseases

Caveolin-1 (CAV1) is the scaffold protein of caveolae, which are minute invaginations of the cell membrane that are involved in endocytosis, cell signaling, and endothelial-mediated inflammation. CAV1 has also been reported to have a dual role as either a tumor suppressor or tumor promoter, depending on the type of cancer. Inflammation is an important player in tumor progression, but the role of caveolin-1 in generating an inflammatory milieu remains poorly characterized. We used a caveolin-1-knockout (CAV1−/−) mouse model to assess the inflammatory status via the quantification of the pro- and anti-inflammatory cytokine levels, as well as the ability of circulating lymphocytes to respond to nonspecific stimuli by producing cytokines. Here, we report that the CAV1−/− mice were characterized by a low-grade systemic proinflammatory status, with a moderate increase in the IL-6, TNF-α, and IL-12p70 levels. CAV1−/− circulating lymphocytes were more prone to cytokine production upon nonspecific stimulation than the wild-type lymphocytes. These results show that CAV1 involvement in cell homeostasis is more complex than previously revealed, as it plays a role in the inflammatory process. These findings indicate that the CAV1−/− mouse model could prove to be a useful tool for inflammation-related studies