Автоматизация доставки, установки и обновления лицензированного программного обеспечения на базе веб-сервиса UTS Marketplace

Работа посвящена проектированию и разработке информационной системы для автоматизации процессов лицензирования и доставки программного обеспечения на устройства клиентов, его своевременного обновления и контроля за его исполнением. Разрабатываемая информационная система состоит из web-сервисов, интегрируемых с сервисом цифрового распространения программного обеспечения UTS Marketplace и кроссплатформенного desktop-клиента UTS Launcher. Результаты работы позволят в значительной мере автоматизировать бизнес-процессы компании ООО "Универсальные терминал системы".The work is devoted to the design and development of an information system for automating licensing and software delivery processes to customer devices, its timely updating and monitoring of its execution. The developed information system consists of web services that are integrated with the UTS Marketplace software digital distribution service and the UTS Launcher cross-platform desktop client. The results of the work will significantly automate the business processes of the company Universal Terminal Systems LLC

Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants

Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative stress plays a key role in driving both extrinsic and intrinsic aging. Sunlight exposure has also been a major contributor to extrinsic photoaging of the skin as its oxidising components disrupt both redox- and iron-homeostasis, promoting oxidative damage to skin cells and tissue constituents. Upon oxidative insults, the interplay between excess accumulation of ROS and redox-active labile iron (LI) and its detrimental consequences to the skin are often overlooked. In this review we have revisited the oxidative mechanisms underlying skin damage and aging by focussing on the concerted action of ROS and redox-active LI in the initiation and progression of intrinsic and extrinsic skin aging processes. Based on these, we propose to redefine the selection criteria for skin antiaging and photoprotective ingredients to include natural antioxidants (AOs) exhibiting robust redox–balancing and/or iron-chelating properties. This would promote the concept of natural-based or bio-inspired bifunctional anti-aging and photoprotective ingredients for skincare and sunscreen formulations with both AO and iron-chelating properties

Trophoblast phagocytic program: roles in different placental systems

Although not belonging to the class of professional phagocytes, in many species trophoblast cells exhibit intense phagocytic activity. The complete range of physiological functions of trophoblast phagocytosis has not yet been fully characterized. Close association between the trophoblast and nutrition was determined many years ago. Hubrecht (1889) when proposing for the first time the name trophoblast to the external layer of the blastocyst, directly established the nutritive significance of this embryonic layer. Indeed, histotrophic phagocytosis, i.e. the internalization of maternal cells and secreted materials, is considered an important function of the trophoblast before the completion of the placenta. Recently, however, unexpected characteristics of the trophoblast have significantly enhanced our understanding of this process. Roles in acquisition of space for embryo development, in tissue remodeling during implantation and placentation and in defense mechanisms are highlighting how this cellular activity may be relevant for the maternal-fetal relationship beyond its nutritional function