Effects of shock waves on combustion efficiency of supersonic flames

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76988/1/AIAA-1998-1058-361.pd

Using PLIF determined flame structure to analyze supersonic combustion efficiencies

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77112/1/AIAA-1999-445-972.pd

Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation

AbstractCurrent antiretroviral therapy (ART) for HIV/AIDS slows disease progression by reducing viral loads and increasing CD4 counts. Yet ART is not curative due to the persistence of CD4+ T-cell proviral reservoirs that chronically resupply active virus. Elimination of these reservoirs through the administration of synergistic combinations of latency reversing agents (LRAs), such as histone deacetylase (HDAC) inhibitors and protein kinase C (PKC) modulators, provides a promising strategy to reduce if not eradicate the viral reservoir. Here, we demonstrate that largazole and its analogues are isoform-targeted histone deacetylase inhibitors and potent LRAs. Significantly, these isoform-targeted HDAC inhibitors synergize with PKC modulators, namely bryostatin-1 analogues (bryologs). Implementation of this unprecedented LRA combination induces HIV-1 reactivation to unparalleled levels and avoids global T-cell activation within resting CD4+ T-cells.</jats:p

Construction of the GAMCIT gamma-ray burst detector (G-056)

The GAMCIT (Gamma-ray Astrophysics Mission, California Institute of Technology) payload is a Get-Away-Special payload designed to search for high-energy gamma-ray bursts and any associated optical transients. This paper presents details on the development and construction of the GAMCIT payload. In addition, this paper will reflect upon the unique challenges involved in bringing the payload close to completion, as the project has been designed, constructed, and managed entirely by undergraduate members of the Caltech SEDS (Students for the Exploration and Development of Space). Our experience will definitely be valuable to other student groups interested in undertaking a challenge such as a Get-Away-Special payload

Comparison of Chemiluminescence, OH PLIF, and NO PLIF for Determination of Flame Response to Acoustic Waves

Various techniques have been employed by investigators to measure the response of flames to unsteady changes, but there has been no systematic study of the relative benefits and drawbacks of these competing techniques. The goal of this work is to characterize the performance of two different measurement techniques applied in three ways and to examine the differing insights they offer for the response of a flame in a periodic acoustic field. The burner configuration consists of a jet flame in a partial enclosure that stabilizes the flame approximately 8 cm above the jet exit. This burner is installed in an acoustic chamber that has actively-controlled, frequency-selectable, acoustic forcing. Flame response data for different frequencies obtained with chemiluminescence, OR PLIF, and NO PLIF measurement techniques is the basis for this work. Analysis of the data shows the complexity of the measurement required to achieve a given level of understanding of the flame's behavior. The usefulness of these techniques in flame response measurements individually and taken in combination is discussed, with examples