Screening-Limited Response of NanoBiosensors

Despite tremendous potential of highly sensitive electronic detection of bio-molecules by nanoscale biosensors for genomics and proteomic applications, many aspects of experimentally observed sensor response (S) are unexplained within consistent theoretical frameworks of kinetic response or electrical screening. In this paper, we combine analytic solutions of Poisson-Boltzmann and reaction-diffusion equations to show that the electrical response of nanobiosensor varies logarithmically with the concentration of target molecules, time, the salt concentration, and inversely with the fractal dimension of sensor surface. Our analysis provides a coherent theoretical interpretation of wide variety of puzzling experimental data that have so far defied intuitive explanation.Comment: 7 pages, 2 figure

Preference programming and inconsistent interval matrices

The problem of derivation of the weights of altematives from pairwise comparison matrices is long standing. In this paper,Lexicographic Goal Programming (LGP) has been used to find out weights from pairwise inconsistent interval judgment matrices. A number of properties and advantages of LGP as a weight determination technique have been explored. An algorithm for identification and modification of inconsistent bounds is also provided. The proposed technique has been illustrated by means of numerical examples.Analytic hierarchy process; Interval judgment; Preferente programming