Bifurcation in cell cycle dynamics regulated by p53

We study the regulating mechanism of p53 on the properties of cell cycle dynamics in the light of the proposed model of interacting p53 and cell cycle networks via p53. Irradiation (IR) introduce to p53 compel p53 dynamics to suffer different phases, namely oscillating and oscillation death (stabilized) phases. The IR induced p53 dynamics undergo collapse of oscillation with collapse time \Delta t which depends on IR strength. The stress p53 via IR drive cell cycle molecular species MPF and cyclin dynamics to different states, namely, oscillation death, oscillations of periods, chaotic and sustain oscillation in their bifurcation diagram. We predict that there could be a critical \Delta t_c induced by p53 via IR_c, where, if \Delta t < \Delta t_c the cell cycle may come back to normal state, otherwise it will go to cell cycle arrest (apoptosis)

Aluminide Coatings on Titanium-based Alloy IMI-834 for High Temperature Oxidation Protection

Microstructural aspects and cyclic oxidation behaviour of plain aluminide and Pt-aluminide coatings on the near-a Ti-alloy IMI-834 have been studied. Both the coatings provide good oxidation resistance to the above alloy at 650 °C, 750 °C, and 850 °C. However, significant cracking develops in the coatings during coating formation as well as during cyclic oxidation exposure. The extent of cracking during oxidation is found to increase with the exposure temperature. Presence of through-thickness cracks in the coatings leads to localised oxidation damage of the underlying substrate at all the three temperatures. At 850 °C, such localised oxidation generates enough TiO2 so that this oxide phase grows through the cracks and emerges at the sample surface forming a clearly identifiable mud-crack pattern. The extent of such oxidation damage is comparatively much lower at 750 °C and 650 °C.Defence Science Journal, 2011, 61(2), pp.180-190, DOI:http://dx.doi.org/10.14429/dsj.61.47

Initial conditions from the shadowed Glauber model

The two component Monte-Carlo Glauber model predicts a knee-like structure in the centrality dependence of elliptic flow $v_2$ in Uranium+Uranium collisions at $\sqrt{s_{NN}}=193$ GeV. It also produces a strong anti-correlation between $v_2$ and $dN_{ch}/dy$ in the case of top ZDC events. However, none of these features have been observed in data. We address these discrepancies by including the effect of nucleon shadowing to the two component Monte-Carlo Glauber model. Apart from addressing successfully the above issues, we find that the nucleon shadow suppresses the event by event fluctuation of various quantities, e.g. $\varepsilon_2$ which is in accordance with expectation from the dynamical models of initial condition based on gluon saturation physics.Comment: version accepted for publication in Physics Letters