Electrical stimulation of prelymbic with different currents intensities on morphine induced spatial memory deficit in rats

Background: The medial prefrontal cortex (mPFC) is a part of brain reward system involved in cognitive functions such as learning and memory. Previous studies showed that electrical stimulation of prelymbic produced different effects on morphine-induced condition place preference. In this study, we investigated the electrical stimulation with different current intensities on spatial memory in rats. Materials and Methods: In this study, male Wister rats weighing approximately 200–300 g were used. The effect of prelymbic electrical stimulation with 25 and 150 μA currents intensities in healthy and addicted rats on spatial memory was studied. Spatial memory was investigated using the Morris water maze test in addicted rats after 9 days of electrical stimulation. Results: Our findings have shown that morphine reduces the memory and learning, whereas the present results indicated that electrical stimulation of prelymbic area with current intensity of the 25 μA shortened the time and distance to reach to platform that indicated improvement in spatial memory on addicted rats. Whereas the electrical stimulation of prelymbic area with the current intensity of 150 μA has special weakening effects on spatial memory and prolongs the time and distance to reach the platform. Conclusions: The electrical stimulations of prelymbic with 25 μA current intensity improved the spatial memory in addicted rats while with 150 μA current intensity weakened spatial memory in rats. It is possible that increase in the release of some neurotransmitters reverses the effect of morphine on spatial memory

Effect of Different Salinity Levels on Essential Oil Content and Composition of Dracocephalum moldavica

ABSTRACT In order to study the effect of salinity on quantity and quality of essential oil of moldavian balm, a pot experiment was carried out in a completely randomized design with 5 treatments and 4 replications in controlled environment of green house. The treatments were different levels of salinity including 0, 10, 25, 40 and 50 mM applied by NaCl. Clevenger method was used to extract the essential oils from the foliage of the treated plants. Results indicated that by increment in salinity levels, essential oil content increased but did not have a significant effect. The highest essential oil content (0.32%) was extracted from 50 mM of salinity treatment. Essential oil components were analyzed and identified by GC and GC/MS machines. The results indicated that in different levels of salinity stress, different components were produced by Dracocephalum moldavica. The major constituents of D. moldavica oil were identified as: geranyl acetate, geraniol, geranial, neral, methyl citronellate and neryl acetate. The highest amount of the main essential oil components were geranyl acetate (44.5%) in 10 mM NaCl and geraniol in control treatments. For both geranial and neral, the highest amount was observed in 25 mM NaCl treatment

The comparison of spiritual health and self-esteem in women with and without sexual violence

Background and aim: Sexual violence is a serious public health problem which is common around the world. The aim of this study was to evaluate spiritual health and self-esteem in sexual violence victims. Methods: This cross-sectional study was performed on 66 subjects in the group of sexual violence women and 147 subjects in the group of women with no experience of sexual violence who referred to Tehran Forensic Medical Center and the health centers of Shahid Beheshti University of Medical Sciences respectively, in 2015, in Tehran, Iran. Sexual violence was considered as vaginal or anal penetration. Paloutzian & Ellison spiritual health questionnaire and Rosenberg self-esteem scale were used for data collecting. Data were analyzed using IBM-SPSS version 21. The Kolmogorov Simonov test was used for normality distribution of variables. Descriptive and the Mann-Whitney tests were used to analyze the data. Statistical significance was set to p<0.05. Results: Sexual activity in both groups was started at 20 years old. Most of the abused subjects were single (48.8%), with education level below diploma (55.2%), unemployed (67%) and with an average annual income of 200 million Rials ($7,000). Familiarity with the offender was mostly as friendship (42.4%), and the offence had occurred through deception (37.8%). No significant difference was found between the total mean scores of self- esteem in the two groups (M1: 21.89, M2: 21.02; p=0.76) while a significant difference was seen between the mean scores of spiritual health, which indicates a lower level of spiritual health in women with sexual violence (M1: 74.59 (2.03), M2: 86.39 (3.12); p<0.001). Conclusion: The results of the present study highlight the importance of spirituality in sexual violence so policies to promote spiritual health are recommended to protect wome

Extraction of phenol compound from Mentha piperita by ultrasonic waves based on a response surface methodology

In this study, optimization of the extraction of phenol compounds from Mentha piperita using ultrasonic waves with response surface methodology (RSM) was assessed. In this regard, a central composite design with three independent variables of time (5, 27.5, and 50 min), temperature (25, 45, and 65°C), and concentrations of ethanol in the water–ethanol solution (0%, 50%, and 100%) was used. Besides, the antioxidant activity tests (DPPH radical scavenging assay, ferric reducing antioxidant power [FRAP], and oxidative stability indexes [OSI]) were examined. Significant effects of independent variables on the extraction of phenol compound, DPPH radical scavenging power, and OSI of M. piperita extract, with the regression coefficients of 0.89, 0.92, and 0.94, respectively, were noted. However, no significant difference in terms of the FRAP among different treatments was noted. Also, the best antioxidant activity of M. piperita was obtained by using the ultrasonic wave for 50 min at 65°C and 59.6% v/v ethanol/water solution. While the findings of RSM confirmed the experimental results, due to the favored properties of M. piperita extract by the proposed method, further research to investigate possible applications in the food industry is recommended

Incorporation of the nanoencapsulated polyphenolic extract of Ferula persica into soybean oil: Assessment of oil oxidative stability

In the present study, for the first time, the biological activities of Ferula persica extract (FPE) coated with locust bean gum (LBG) and chitosan in W/O/W emulsions were investigated. Based on the findings, the Z-average size of emulsions coated by chitosan, LBG, and the complex of chitosan and LBG (1:1) (CCL) was 115.47, 128.37, and 68.12 nm, respectively. The encapsulation efficiency of the phenolic extracts in the powder produced by chitosan, LBG, and CCL decreased from 85.3 to 64.1, from 89 to 71.4, and from 93.3% to 77.9% during 24-day storage, respectively. Also, the application of the coating in the encapsulation of FPE increased the antioxidant efficacy in soybean oil while compared with tert-butylhydroquinone (TBHQ) and un-encapsulated FPE. In this regard, The FPE nanoencapsulated by CCL showed the best antioxidative activity in soybean oil, followed by the FPE of nanoencapsulated by LBG and chitosan, respectively, which can be correlated with higher levels of polyphenolic compounds release over time in the sample coated with CCL. In this context, the encapsulation with CCL can be proposed as a promising technique to improve the antioxidant activity of extracts

A Bender’s Algorithm of Decomposition Used for the Parallel Machine Problem of Robotic Cell

The present research addresses the single transportation robot used to alleviate problems of robotic cell scheduling of the machines. For the purpose of minimizing the make-span, a model of mixed-integer linear programming (MILP) has been suggested. Since the inefficiency exists in NP-hard, a decomposition algorithm posed by Bender was utilized to alleviate the problem in real life situations. The proposed algorithm can be regarded as an efficient attempt to apply optimality Bender’s cuts regarding the problem of parallel machine robotic cell scheduling in order to reach precise resolutions for medium and big sized examples. The numerical analyses have demonstrated the efficiency of the proposed solving approach