Holographic direct pulsed laser writing of two-dimensional nanostructures

The development of accurate and rapid techniques to produce nanophotonic structures is essential in data storage, sensors, and spectroscopy. Existing bottom-up and top-down approaches to fabricate nanophotonic devices are high cost and time consuming, limiting their mass manufacturing and practical applications. Here, we demonstrate a strategy to rapidly create 25–40 nm thick 1/2D Au–Ti nanopatterns using holographic direct laser interference patterning (DLIP). Pulses of an Nd:YAG laser (1064 nm) in holographic Denisyuk reflection mode were used to create ablative interference fringes. The constructive interference antinode regions of the standing wave selectively ablated a Au–Ti layer in localized regions to controllably form nanogratings. Varying the laser exposure parameters allowed for rapid patterning of 2D square and rectangular arrays within seconds. Controlling the distances between the laser source, recording medium, and the object, allowed for achieving a 2D spatial grating periodicity of 640 nm × 640 nm. Diffracted and transmitted light spectra of 2D nanostructure arrays were analyzed using angle-resolved measurements and spectroscopy

A novel explanatory hybrid artificial bee colony algorithm for numerical function optimization

Over the past few decades, there has been a surge of interest of using swarm intelligence (SI) in computer-aided optimization. SI algorithms have demonstrated their efcacy in solving various types of real-world optimization problems. However, it is impossible to fnd an optimization algorithm that can obtain the global optimum for every optimization problem. Therefore, researchers extensively try to improve methods of solving complex optimization problems. Many SI search algorithms are widely applied to solve such problems. ABC is one of the most popular algorithms in solving diferent kinds of optimization problems. However, it has a weak local search performance where the equation of solution search in ABC performs good exploration, but poor exploitation. Besides, it has a fast convergence and can therefore be trapped in the local optima for some complex multimodal problems. In order to address such issues, this paper proposes a novel hybrid ABC with outstanding local search algorithm called β-hill climbing (βHC) and denoted by ABC–βHC. The aim is to improve the exploitation mechanism of the standard ABC. The proposed algorithm was experimentally tested with parameters tuning process and validated using selected benchmark functions with diferent characteristics, and it was also evaluated and compared with well-known state-of-the-art algorithms. The evaluation process was investigated using diferent common measurement metrics. The result showed that the proposed ABC–βHC had faster convergence in most benchmark functions and outperformed eight algorithms including the original ABC in terms of all the selected measurement metrics. For more validation, Wilcoxon’s rank sum statistical test was conducted, and the p values were found to be mostly less than 0.05, which demonstrates that the superiority of the proposed ABC–βHC is statistically signifcant

Thymoquinone Potentiates the Effect of Phenytoin against Electroshock-Induced Convulsions in Rats by Reducing the Hyperactivation of m-TOR Pathway and Neuroinflammation: Evidence from In Vivo, In Vitro and Computational Studies

Epilepsy is a chronic neurodegenerative disease characterized by multiple seizures, hereto 35% of patients remain poor responders. Phenytoin (PHT; 20 and 40 mg/kg) and thymoquinone (THQ; 40 and 80 mg/kg) were given alone and as a low dose combination for 14 days (p.o), prior to challenge with maximal electroshock (MES; 180 mA, 220 V, 0.2 s). Apart from observing convulsions, hippocampal mTOR, IL-1β, IL-6 and TNF-α levels were measured. Hippocampal histomorphological analysis was also conducted. In vitro cell line studies and molecular docking studies were run in parallel. The results revealed the synergistic potential of the novel duo-drug combination regimen: PHT (20 mg/kg) and THQ (40 mg/kg) against MES-induced convulsions. MES amplified signaling through mTOR, and inflated the levels of proinflammatory markers (IL-1β, IL-6 and TNF-α), which was significantly averted (p < 0.001) with the said drug combination. The computational studies revealed that PHT and THQ cooperatively bind the active site on Akt (upstream target of m-TOR) and establish a good network of intermolecular interactions, which indicates the sequential inhibition of PI3K/Akt/m-TOR signaling with the combination. The combination also increased cell viability by 242.81% compared to 85.66% viability from the the toxic control. The results suggest that the PHT and THQ in combination possesses excellent anticonvulsant and neuroprotective effects