1 research outputs found
Preliminary evaluation of the anti-inflammatory and anti-hepatotoxic activities of 'Parsley' Petroselinum crispum in rats
Objective: To study the anti-inflammatory and hepatoprotective properties of an ethanolic extract of
Parsley 'Petroselinum crispum' leaves. Materials and methods: An ethanolic extract of Parsley was subjected
for evaluation of anti-inflammatory and anti-hepatotoxic activities against inflammation induced by
carrageenan and cotton pellet granuloma and hepatic damage induced by carbon tetrachloride, respectively
in rats. Apart from enzymes, non-protein sulfhydryl (NP-SH) groups were also estimated in liver.
Histopathological test on liver was carried out and phenobarbitone-induced sleeping time in mice was also
measured in different groups. Results: The phy tochemical screening of the extract revealed the presence of
flavonoids, tannins, sterols and or triterpenes. The extract exhibited significant protection against
carrageenan-induced inflammation, cotton pellet-induced granuloma and CCl4-induced hepatic damage.
Conclusion: Petroselinum crispum exhibited significant antiinflammatory and anti-hepatotoxic activities
which merits further detailed investigations.Corresponding author
S. Rafatullah, Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Email: [email protected]