Iodine-123 and Fluorine-18 radiolabeled analogues of WAY-100635 as potential radioligands for imaging the 5-HT1A receptor in the brain

Dongen, G.A.M.S. [Promotor]van Booij, J. [Promotor]Herscheid, J.D.M. [Copromotor

Evaluation of the antimicrobial (antibacterial and antifungal) activity of ethanolic extracts of some medical plants.

The aim of the study was to evaluate the antimicrobial activity ethanolic extracts of Nigella sativa (N.sativa), Zingiber officinal (Ginger), and Trigonella foenum graecum (Fenugreek), in three concentration (50mg/ml, 100mg/ml, and 200mg/ml).The antimicrobial activities have been evaluated against two gram positive bacteria: Staphylococcus aureus, Streptococcus sp., and two gram negative bacteria: Escherichia coli, Proteus sp. And two pathogenic fungi: Candida albicans, Sacromysis sp. Ethanolic extract of Ginger showed the maximum antimicrobial against gram positive bacteria and Candida  albicans fungi while Fenugreek extract give the potent effect against gram negative bacteria and Sacromysis fungi. On the other hand N. sativa extract showed the minimum antimicrobial effects. The results indicate the efficacy of the plants as a potent antimicrobial agents. Key words: Antibacterial, Antifungal, Ethanolic extract, Nigella sativa, Ginger, Fenugreek

Effect of Nursing Job on Fertility Potential of Nurses in Babylon Province

Objective: The aim of the study: To study the effect of nursing job on nurses fertility potential. Back ground: Fertility potential refers to the ability of couples to reproduce and depends on both female and male partners. Human Fertility Potential is a very sensitive process which can be influenced by many factors such as jobs opportunities.  Fertility potential can be measured by ovarian reserve markers. Methods: This is a case control study conducted in Hilla Teaching hospital and Babylon teaching hospital for maternity and pediatric; form: May 2015 - November 2015.  Fifty women were included in this study working as nurses in gynecological and obstetric department (Number =50) and eighty-one women as a control group (Number = 81). Assessment of effect of nursing job was done by standard questionnaire and basal Hormonal levels (follicle stimulating hormone, estradiol hormone, prolactin hormone and thyroid stimulating hormone) were determine women by using (mini VIDAS) method. Result: There is a significant difference in the residence, educational level, menstrual cycle regularity between nurses and control group (p<0.05). Significant differences (p<0.05) were identified in cycle day two serum level of Estradiol and Prolactin hormones, between the nurses group and control group . Conclusion: Nurses working in gynecological and obstetric wards are liable for the effects of shift work which may disturb circadian rhythm and may cause cycle irregularities and alter endocrine function and possibly the regulation of reproductive hormones and fertility. Key words: Fertility potential, follicle stimulating hormone, estradiol hormone, prolactin hormone, thyroid stimulating hormone, nursing job

FORMULATION AND EVALUATION OF EFFERVESCENT GRANULES OF IBUPROFEN

Objective: The object of this investigation was to formulate and evaluate effervescent granules of ibuprofen, to increase its dissolution rate to get rapid analgesic and antipyretic effects. Methods: Five formulas (F1-F5) of effervescent ibuprofen granules were formulated by the wet granulation method. Croscarmellose sodium, powder of banana and other ingredients were used in the formulation of effervescent granules. Evaluation studies were carried out for all five formulas, these include: (compatibility study, flowability study, % of drug content, effervescent time and in vitro dissolution study). Results: The results show that the formulated granules have good flow properties with suitable bulk density for the uniting dose. FTIR study shows that there is no drug interaction with other ingredients in the formula. All five formulas have effervescent time less than 3 min, F5 show the best drug release 99.1±1 and effervescent time about 80 sec. Conclusion: Ibuprofen was successfully formulated and evaluated as effervescent granules by using a combination of croscarmellose sodium and banana powder

Annealing Effect on the Structural and Optical Properties of Sol- Gel Deposited Nanocrystalline CdO Thin Films

In this paper CdO thin films have been prepared by using SOL-GEL method with spin coating technique, by depoited four layers  of mixtuer solution contians Cadmium acetate dehydrate, Triethylamine, glycerol and ethanol.The spin coated solution were dried at 100°C and annealied at (300,350 and 400 oC temperatures ). The x-ray diffraction techniques and UV-VIS spectrophotometer have confirmed the structural and the optical properties the prepared thin films. CdO thin films were found to have polycrystalline nature with cubic rock salt phase. The crystallinity being improved, the FWHM decreases and the grain size of the CdO thin films increased with increasing the annealing temperatures. The average grain size is observed in the range  (23.97 - 30.47) nm which indicate that the prepared film have a nanocrystalline structure. From optical analysis, it can be seen that there are an increases in the absorbance and decreases in the trancemittance  of the prepared films with the increasing of the annealing temperatures.The optical band gap decreases  from 2.556, to 2.081 eV with increasing of annealing temperature fromm 300 to 400° C, this suggested that the optical band gap for CdO nanocrystalline thin films is strongly dependent on the annealing temperature. Keywords: CdO thin films, Sol–gel spin–coating, Structural and Optical properties, annealing temperature

Gait Analysis Before and After Total Knee Replacement

Total knee replacement is a surgical procedure for treatment of knee Osteoarthritis, Rheumatoid arthritis and posttraumatic arthritis. The main goals of TKR are relieve the pain, restore function, mobility and restore normal limb alignment for the patients. The aim of the study to investigate the gait dynamic improvements following TKR surgery by compare the dynamic parameter pre-operative and post-operative and then comparing the results with the normal gait parameters. The gait analysis was performed on five patients before and after they underwent unilateral TKR surgery. After three months from the total knee replacement there was a remarked increase in the function and decrease in pain. The varus and valgus malalignment will be return to normal alignment after operation, which is one of the main goals of the TKR. Post-operative cadence is higher than pre-operative for four patients, post-operative speed is faster than pre-operative for four patients and post-operative stride length is larger than pre-operative for four patients. The patients continue to walk with significant gait abnormalities by examining the kinetics and the kinematics of the operated limb, the results show the knee function not fully restored three months after unilateraL TKR surgery

عدم تماثل المعلومات وأثره في تكلفة رأس المال دراسة في عَينَّة من سوق الأردن للأوراق المالية

هدفت الدراسة إلى اختبار وتحليل أثر عدم تماثل المعلومات في تكلفة رأس المال لدى عَينَّة البحث منطلقة من مشكلة بحثية وهي "هل أنَّ سوق الأردن للأوراق المالية يفصح عن معلوماته بشكل دقيق وبالوقت المناسب؟" وما هو تأثير عدم تماثل المعلومات في تكلفة رأس المال للشركات المدرجة في السوق؟ وعلى هذا الأساس افترضت الدراسة "وجود أثر ذو دلاله إحصائية معنوية للمعلومات غير المتماثلة في تكلفة رأس المال " تمثلت الدراسة وعيَنَّتها بسوق الأردن للأوراق المالية، حيث اعتمدت البيانات الربع سنوية المنشورة في سوق الاوراق المالية لـ (11) سنة للمدة (2010-2020)، وبهذا تُصبح عدد المشاهدات (44) مشاهدة، وتم تحليل البيانات واستخدم أنموذج الانحدار الذاتي لقياس تأثير المتغيرات المفسرة في المتغير المستجيب، توصلت الدراسة بإثبات التأثير العكسي لكل من حجم التداول وهامش الربح في (المتوسط المرجح لتكلفة رأس المال) (WACC) في الأجل القصير، لم يثبت تأثير معدل دوران السهم في ذات السوق، وأظهرت النتائج التأثير العكسي والسالب لكل من حجم التداول وهامش الربح في (المتوسط المرجح لتكلفة رأس المال) (WACC)  في الأجل الطويل، ولم يثبت تأثير معدل دوران السهم في سوق الأردن للأوراق المالية، وأوصت الدراسة بضرورة تسليط الضوء مشكلة عدم تماثل المعلومات بوصفها أحد أسباب ظهور الأزمات المالية ومنبع المخاطر الأخلاقية، ويُعُّد استخدام المعايير المحاسبية للإفصاح العادل حل للحد هذه المشكلة والتقليل من المخاطر الاخلاقية والاختيار العكسي

Revisiting Fara: Comparison of merged prospection results of diverse magnetometers with the earliest excavations in ancient Suruppak from 120 years ago

Ancient Suruppak, today Fara, was one of the major Sumerian cities in Mesopotamia. It was situated along one of the ancient watercourses of the Euphrates River. Findings date it back to the Jemdet Nasr period around 3000 bc with a continuous occupation until the end of the Ur III period around 2000 bc. Fara was first explored and excavated by the Deutsche Orient-Gesellschaft in the years 1902 and 1903 under the direction of Walter Andrae. Multiple excavation trenches with lengths up to 900 m transect the 1 km(2) wide mound and are still visible today which enables us to georeference the excavation maps. Today, the 2.2 km(2) wide archaeological area is dry and without any vegetation. Thousands of deep looting pits are covering the majority of mound which not only destroyed its upper metres but also challenge the application of geophysical prospection methods and their interpretation. The magnetometer prospecting of selected areas on and around the mound was carried out with three devices, two total field magnetometers and one gradiometer. The individual survey areas were combined in post-processing by applying a high-pass filter on the total field data sets and multiplying the vertical gradiometer data sets by a factor of two. This approach provides visually uniform magnetograms, despite being obtained by different devices, which simplifies subsequent visual interpretation. These magnetograms enable us to review, and to extend the results of the old excavations. The comparison show a good correlation in accuracy to the old drawings and positive identification of the already excavated features with magnetometry. Highlights of the survey are the discovery of the city wall confirming its existence, the layout of a unique building complex in the centre of the mound, likely a temple, traces of canals inside the city and an evaluation of magnetometer prospection over a looted area

Attitude and intention of Iraqi healthcare providers to get vaccinated against COVID-19: a cross-sectional study

Background: International efforts to confront the COVID-19 pandemic are joining forces by accelerating the pace of vaccination. This study aims to explore the attitude and the intent to get vaccinated against COVID-19 among healthcare providers (HCPs) in Iraq. Methods: A cross-sectional survey was conducted in January 2021 using web-based facilities to access the respondents. The data were collected through a semi-structured and self-administered questionnaire, including sociodemographic and close-ended questions related to attitude and intention toward COVID-19 vaccination. Bivariate and multivariate logistic regression were recruited to predict variables. The statistical significance is considered at less than 0.05. Results: Data of 209 HCPs with a mean age of 45.12 (± 6.37) years have undergone final analysis. Most of the HCPs were males (112, 53.6%) and nurses (110, 52.6%), who had close contact (64.6%) with COVID-19 patients, and forty percent have been infected with COVID-19. Overall, 115 HCPs (58.0%) reported intention to get vaccinated compared to 94 (42.0%) who declined vaccination. Variables associated with intention to get vaccinated among HCPs were high attitude toward COVID-19 vaccination (odds ratio (OR) =  1.740, 95% confidence interval (CI): 0.799, 3.786), aged less than 45 years (OR = 3.713; 95% CI: 1.647, 8.367), married (OR = 2.155; 95% CI: 0.984, 4.720), highly educated (OR = 2.657; 95% CI: 1.202, 5.871), doctors (OR = 3.153; 95% CI: 1.428, 6.963), contracted with COVID-19 (OR = 4.119; 95% CI: 1.623, 10.455), directly engaged in management of COVID-19 patients (OR = 3.962; 95% CI: 1.569, 10.005), and had lost a close relative due to COVID-19 (OR = 5.698; 95% CI: 1.506, 12.564). Conclusion: The urgent need to improve the COVID-19 vaccine uptake rates among Iraqis requires a positive attitude and a high vaccination rate among HCPs