4 research outputs found
Histological and immunohistochemical effects of L-arginine and silymarin on TNBS-induced inflammatory bowel disease in rats
Inflammatory bowel disease (IBD) is a
chronic disease that affects quality of life. Various
mediators are involved in IBD pathogenesis including
inducible nitric oxide synthase (iNOS), nuclear factor
kappa B (NF-ÎșB), cytochrome c, heat shock protein 70
(HSP70) and tumor necrosis factor (TNF)-α. L-Arginine
(L-Arg) can be depleted in IBD, and silymarin inhibits
neutrophil infiltration, NF-ÎșB, and TNF-α, which have
crucial roles in inducing IBD. This study aimed to
investigate whether silymarin and L-Arg supplementation decreases IBD progression in trinitrobenzinesulfonic acid (TNBS)-induced colitis. Fifty adult male
albino rats were randomized into five groups (10 animals
per group): Group I rats orally received 10 mg
silymarin/100 g body weight once daily; Group II rats
orally received 2 mg L-Arg/100 g body weight once
daily; Group III rats rectally received 0.85 mL TNBS in
50% ethanol to induce colitis; Group IV rats were treated
similar to group III and, on recovery from anesthesia,
received silymarin as described for group I; and Group
V rats were treated similar to group III and, on recovery
from anesthesia, received L-Arg as described for group
II. On day 7, the rats were anesthetized, and blood
samples were collected to determine the serum
concentrations of TNF-α. Laparotomy and total
colectomy were performed for macroscopic,
histological, and immunohistochemical investigations.
The results showed that silymarin and L-Arg macroscopically and microscopically ameliorated TNBS-induced
colitis; significantly decreased the serum levels of TNFα; inhibited the colonic expression of iNOS, NF-ÎșB, and
cytochrome c; and increased expression of HSP70. Our
results suggest that these complementary medicines
could be used to supplement current treatments for IBD
Effect of Duration of Exposure to Cement Dust on Respiratory Function of Non-Smoking Cement Mill Workers
Abstract: This study aimed to determine the effect of long term exposure to cement dust on lung function in non-smoking cement mill workers. This is a cross-sectional study of respiratory functions. Spirometry was performed in 100 apparently healthy volunteers; 50 non-smoking cement mill workers and 50 non-smoking un-exposed subjects. Based on the duration of exposure, cement mill workers were divided into three groups, less than 5, 5â10 and greater than 10 years. All subjects were individually matched for age, height, weight, and socioeconomic status. Pulmonary function test was performed by using an electronic spirometer. Significant reduction was observed in the mean values of Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), Peak Expiratory Flow (PEF) and Maximal Voluntary Ventilation in cement mill workers who had been working in the cement industry for more than 10 years compared to their matched un-exposed group. Lung functions in cement mill workers were significantly impaired and results show a long term duration response effect of years of exposure to cement dust on lung functions
Effect of Duration of Disease on Ventilatory Function in an Ethnic Saudi Group of Diabetic Patients
Diabetes mellitus is a leading cause of illness and death across the world and is responsible for a growing
proportion of global health care expenditures. The present study was designed to observe the effect of diabetes
mellitus on lung function in patients with diabetes belonging to a specific ethnic group, namely Saudis.This work was supported by Grant 02-438, College of Medicine Research Centre (CMRC), King Saud University, Riyadh, KSA.Corresponding Author:
Sultan Ayoub Meo, MBBS, Ph.D., Department of Physiology (29), College of Medicine, King Khalid University Hospital, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia
email: [email protected] or [email protected]