The Informational Needs of Mothers about Physical Care at Home for Children who Underwent Stem Cell Transplants

Background: After children were discharged from the hospital, their mothers generally undertook all of their care responsibilities.Aim: To assess the informational needs of mothers related to the physical care of children who underwent HSCT during the early recovery period (within 3 months after transplantation).Methods: This descriptive and longitudinal study was conducted to assess the informational needs of mothers related to physical care at home of children who underwent HSCT. The sample included the mothers of 74 children who had undergone a transplant within the past three months according to the eligibility criteria. The data collection tools were the (1) Child Information Form and (2) Informational Needs Form. Data collection tools were: (1) ChildInformation Form, and (2) Informational Needs Form.Results: The total mean number of informational needs of mothers was very high at 11.3±3.1 (3-15). Both the “moderate” and “high need” rates of mothers were the highest in the areas of “medications and side effects, anticipated complications and their symptoms, skin care, pain, fatigue, nausea, vomiting, diarrhea and sleepmanagement”.Conclusions: The results revealed that the information needs of mothers for physical care at home of children underwent HSCT was very high. The results can assist in planning nursing strategies and collaborations to improve the discharge process for HSCT nurses, prevent and detect complications early and for decrease readmission rates of patients by public/home health care nurses

Kök Hücre Nakli Yapılan Bir Olguda Karşılaşılan Nutrisyonel Sorunlar ve Uygulamalar

Severe and serious complications affecting nutritional status negatively like gastrointestinal symptoms including mucositis, diarrhea, vomiting, abdominal pain; veno-occlusive disease, graft versus host disease and metabolic disturbance could be seen in pediatric patients. Patients’ oral food consumption decrease dramatically because of both used high dose chemotherapy and can be occure severe complications. Proper nutritional support is very important in this period. In this case report discussed via a case experienced complications and nutritional strategies in transplantation period.Pediatrik hastalarda, Hematopoietik Kök Hücre Nakli (HKHN) sürecinde hastanın beslenme durumunu olumsuz etkileyen mukozit, diyare, kusma, karın ağrısı gibi gastrointestinal semptomlar, veno-oklüzif hastalık, graft versus host hastalığı ve metabolik dengesizlikler gibi ağır ve ciddi komplikasyonlar görülebilmektedir. Gerek kullanılan yüksek doz kemoterapi gerekse gelişebilen ağır komplikasyonlar nedeniyle hastaların oral besin alımları ciddi derecede azalmaktadır. Bu süreçte uygun beslenme desteği son derece önemlidir. Bu yazıda HKHN sürecinde yaşanan kompikasyonlar ve beslenme stratejileri, bir olgu üzerinden aktarılmaktadır

Long-term Quality of Life in Patients with Thalassemia Major following Hematopoetic Stem Cell Transplantation in Childhood

WOS:000600556201329[No Abstract Available

Chimerism Analysis of Children with Allogeneic Stem-Cell transplantation and Its Effect on Survival

BACKGROUND/AIMS: Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is an important and usually the only curative clinical tool for treating pediatric patients with many hereditary and acquired diseases. Although complete donor stem cell engraftment is the desired result of Allo-HSCT, patients do not always have a definite engraftment and end up with mixed chimerism. Many factors both related to patient and transplantation can affect chimerism levels. Additionally, mixed chimerism levels may affect the event free survival (EFS) differently in distinct diseases. The major goals of this study were to determine the first 100-day donor chimerism ratios and to search for a relationship between donor chimerism success (CS) (for malignant diseases, hematopoietic donor chimerism >95%; for non-malignant diseases, >70%) and EFS for pediatric patients.MATERIALS AND METHODS: We collected data from 95 pediatric patients who underwent Allo-HSCT between March, 2005 and April, 2010 at Ege University Hospital with at least one chimerism result obtained within the first 100 days.RESULTS: After checking for all other factors, CS in the first 100 days increases the chance of post-transplant EFS by-3.04 (-4.00 to-2.08) [hazard ratio (HR): 0.05 (p<0.001)]. Neutrophil engraftment was the other factor which was positively correlated with EFS (HR p-value: 0.05)CONCLUSION: There is a positive correlation between CS in the first 100 days and EFS for both malignant and non-malignant diseases

A Case of Allergic Broncopulmonary Aspergillosis Associated With Hematopoietic Stem Cell Transplantation Due to Chronic Granulomatous Disease

###EgeUn###Allergic bronchopulmonary aspergillosis is an immunologic pulmonary disorder caused by hypersensitivity to Aspergillus fumigatus. This disorder is most commonly seen in patients with poorly controlled asthma and cystic fibrosis. It is rarely reported in chronic granulomatous disease patients; however, there are no cases reported with hematopoietic stem cell transplantation in the English literature. Herein, we report a patient with chronic granulomatous disease who had hematopoietic stem cell transplantation and subsequently developed allergic bronchopulmonary aspergillosis

Cerebral Involvement of Hemophagocytic Lymphohistiocytosis in Griscelli Syndrome

Type II Griscelli Syndrome (GS) is caused by a mutation in the RAB27A gene and usually manifests with silvery-gray hair, immune deficiency and the development of hemophagocytic lymphohistiocytosis (HLH). A hematopoietic stem cell transplantation is the curative treatment for HLH and reduced-intensity conditioning prevents the morbidity/mortality in the transplantation related to myeloablative conditioning. We report on a 21-month old boy with cerebral involvement of HLH related to GS

Successful bone marrow transplantation in an 8-month-old patient with chronic granulomatous disease

WOS: 000242293400013PubMed ID: 17172071An eight-month-old boy with chronic granulomatous disease (CGD) received HLA identical sibling bone marrow transplantation (BMT) following busulphan and cyclophosphamide conditioning. No graft-versus-host disease was demonstrated. Five years after transplantation, mixed chimerism was 60% in peripheral blood, and 85% of his neutrophils had normal oxidative burst activity. He is now six years old, in very good health and growing well. In this period, he experienced no severe infectious diseases. To our knowledge, this is the first case of CGD who had BMT in Turkey. His successful outcome illustrates that BMT in a patient with CGD in the first years of life should be considered early if an HLA-matched donor is already available, before development of any recurrent life-threatening infections or irreversible organ damage