Head & Neck Oncology: purpose, scope and goals-charting the future

For many years now there has been a growing frustration with the statistics of head and neck cancer. Despite the many advances in diagnosis and therapy, there has been little change in the prognosis for most cancers of the head and neck in the last 50 years, so what is the point of yet another journal? Well, it is not all bad news

North Sea Infragravity Wave Observations

Coastal safety assessments with wave-resolving storm impact models require a proper offshore description for the incoming infragravity (IG) waves. This boundary condition is generally obtained by assuming a local equilibrium between the directionally-spread incident sea-swell wave forcing and the bound IG waves. The contribution of the free incident IG waves is thus ignored. Here, in-situ observations of IG waves with wave periods between 100 s and 200 s at three measurement stations in the North Sea in water depths of O(30) m are analyzed to explore the potential contribution of the free and bound IG waves to the total IG wave height for the period from 2010 to 2018. The bound IG wave height is computed with the equilibrium theory of Hasselmann using the measured frequency-directional sea-swell spectra as input. The largest IG waves are observed in the open sea with a maximum significant IG wave height of O(0.3) m at 32 m water depth during storm Xaver (December 2013) with a concurrent significant sea-swell wave height in excess of 9 m. Along the northern part of the Dutch coast, this maximum has reduced to O(0.2) m at a water depth of 28 m with a significant sea-swell wave height of 7 m and to O(0.1) m at the most southern location at a water depth of 34 m with a significant sea-swell wave height of 5 m. These appreciable IG wave heights in O(30) m water depth represent a lower bound for the expected maximum IG wave heights given the fact that in the present analysis only a fraction of the full IG frequency range is considered. Comparisons with the predicted bound IG waves show that these can contribute substantially to the observed total IG wave height during storm conditions. The ratio between the predicted bound- and observed total IG variance ranges from 10% to 100% depending on the location of the observations and the timing during the storm. The ratio is typically high at the peak of the storm and is lower at both the onset and waning of the storm. There is significant spatial variability in this ratio between the stations. It is shown that differences in the directional spreading can play a significant role in this. Furthermore, the observed variability along the Dutch coast, with a substantially decreased contribution of the bound IG waves in the south compared to the northern part of the Dutch coast, are shown to be partly related to changes in the mean sea-swell wave period. For the southern part of the Dutch coast this corresponds to an increased difference with the typically assumed equilibrium boundary condition although it is not clear how much of the free IG-energy is onshore directed barring more sophisticated observations and/or modeling

Ameloblastic Carcinoma of the mandible

Odontogenic carcinomas are rare lesions arising from dental embryogenic residues and have been designated by a variety of terms like malignant ameloblastoma, ameloblastic carcinoma, metastatic ameloblastoma or primary intra-alveolar epidermoid carcinoma. Ameloblastic carcinoma combines the histological features of ameloblastoma with cytological atypia, even in the absence of metastasis. The lesion has been reported to arise either from the odontogenic cyst or the ameloblastoma. Majority originate de novo and the remaining are malignant transformation of an ameloblastoma