Differential, Tissue-specific, Transcriptional Regulation of Apolipoprotein B Secretion by Transforming Growth Factor β

n/

Regional and experiential differences in surgeon preference for the treatment of cervical facet injuries: a case study survey with the AO Spine Cervical Classification Validation Group

Purpose: The management of cervical facet dislocation injuries remains controversial. The main purpose of this investigation was to identify whether a surgeon’s geographic location or years in practice influences their preferred management of traumatic cervical facet dislocation injuries. Methods: A survey was sent to 272 AO Spine members across all geographic regions and with a variety of practice experience. The survey included clinical case scenarios of cervical facet dislocation injuries and asked responders to select preferences among various diagnostic and management options. Results: A total of 189 complete responses were received. Over 50% of responding surgeons in each region elected to initiate management of cervical facet dislocation injuries with an MRI, with 6 case exceptions. Overall, there was considerable agreement between American and European responders regarding management of these injuries, with only 3 cases exhibiting a significant difference. Additionally, results also exhibited considerable management agreement between those with ≤ 10 and > 10 years of practice experience, with only 2 case exceptions noted. Conclusion: More than half of responders, regardless of geographical location or practice experience, identified MRI as a screening imaging modality when managing cervical facet dislocation injuries, regardless of the status of the spinal cord and prior to any additional intervention. Additionally, a majority of surgeons would elect an anterior approach for the surgical management of these injuries. The study found overall agreement in management preferences of cervical facet dislocation injuries around the globe

A Meta-analysis of Social Commerce Adoption Research

Social commerce is a subset of e-commerce that utilises social media to facilitate interaction between sellers and consumers. Over the last number of years, the subject of social commerce has attracted significant attention from many researchers as they attempt to understand the factors affecting its adoption by consumers. A review of results from existing studies suggests inconsistent results for many relationships. Hence, this research has conducted a meta-analysis of 65 studies and synthesized the findings from existing studies in order to estimate the cumulative correlation coefficient (β) and significance (p). The investigation found that behavioural intention, trust, perceived usefulness, and social support are frequently examined dependent variables, that are strongly influenced by a number of independent variables. The findings in this study suggests that perceived usefulness, hedonic value, social commerce constructs, subjective norms, informational and emotional support are important for encouraging social commerce adoption. This research highlights various antecedents that have been theoretically examined in different social commerce studies that explore the effect size through meta-analysis

Establishing the injury severity of subaxial cervical spine trauma validating the hierarchical nature of the AO spine subaxial cervical spine injury classification system

Study Design. Global cross-sectional survey. Objective. The aim of this study was to validate the AO Spine Subaxial Cervical Spine Injury Classification by examining the perceived injury severity by surgeon across AO geographical regions and practice experience. Summary of Background Data. Previous subaxial cervical spine injury classifications have been limited by subpar interobserver reliability and clinical applicability. In an attempt to create a universally validated scheme with prognostic value, AO Spine established a subaxial cervical spine injury classification involving four elements: injury morphology, facet injury involvement, neurologic status, and case-specific modifiers. Methods. A survey was sent to 272 AO Spine members across all geographic regions and with a variety of practice experience. Respondents graded the severity of each variable of the classification system on a scale from zero (low severity) to 100 (high severity). Primary outcome was to assess differences in perceived injury severity for each injury type over geographic regions and level of practice experience. Results. A total of 189 responses were received. Overall, the classification system exhibited a hierarchical progression in subtype injury severity scores. Only three subtypes showed a significant difference in injury severity score among geographic regions: F3 (floating lateral mass fracture, P ¼ 0.04), N3 (incomplete spinal cord injury, P ¼ 0.03), and M2 (critical disk herniation, P ¼ 0.04). When stratified by surgeon experience, pairwise comparison showed only two morphological subtypes, B1 (bony posterior tension band injury, P ¼ 0.02) and F2 (unstable facet fracture, P ¼ 0.03), and one neurologic subtype (N3, P ¼ 0.02) exhibited a significant difference in injury severity score. Conclusion. The AO Spine Subaxial Cervical Spine Injury Classification System has shown to be reliable and suitable for proper patient management. The study shows this classification is substantially generalizable by geographic region and surgeon experience, and provides a consistent method of communication among physicians while covering the majority of subaxial cervical spine traumatic injuries

Proceedings Of The 23Rd Paediatric Rheumatology European Society Congress: Part Two

PubMe