A report on ice core drilling on the western plateau of Mt. Belukha in the Russian Altai Mountains in 2003

A 171m deep ice core from the surface to the bottom has been successfully drilled on the West Belukha snow-firn Plateau in the Russian Altai Mountains in the summer of 2003. The drill system used in this project was an electro-mechanical drill with a barrel 135cm long and 9.5cm in inner diameter manufactured by Geo Tecs Co., Japan. The maximum core length for a drilling run is 55cm. It took 87.5 hours in actual working time of 7 working days to drill the core down to the bottom of the glacier. The total number of drilling runs was 325. The mean length of the drilled core was 48.6cm. Most of the cores were not brittle and had a good cylindrical shape. High air temperature above the melting point in the drilling shelter caused some trouble in drilling. One of the major troubles was slip of cutters due to adhesion of cutting tips to the cutters and shoes

Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes

<p>Abstract</p> <p>Background</p> <p>The melanocortin (MC) receptors have a key role in regulating body weight and pigmentation. They belong to the rhodopsin family of G protein-coupled receptors (GPCRs). The purpose of this study was to identify ancestral MC receptors in agnathan, river lamprey.</p> <p>Results</p> <p>We report cloning of two MC receptors from river lamprey. The lamprey receptors, designated MCa and MCb, showed orthology to the MC1 and MC4 receptor subtypes, respectively. The molecular clock analysis suggested that lamprey MC receptor genes were not duplicated recently and diverged from each other more than 400 MYR ago. Expression and pharmacological characterization showed that the lamprey MCa receptor was able to bind and be activated by both lamprey and human MSH peptides. The lamprey MCa receptor had relatively high affinity for ACTH derived peptides similarly to the fish MC receptors. We found that both of the lamprey MC receptors were expressed in skin, while the MCb receptor was also found in liver, heart and skeletal muscle.</p> <p>Conclusion</p> <p>This study shows presence of MC receptors in agnathans indicating early signs of specific functions of melanocortin receptor subtypes.</p

Eccrine porocarcinoma of the head: An important differential diagnosis in the elderly patient

Background: Eccrine porocarcinoma is a rare malignant tumor of the sweat gland, characterized by a broad spectrum of clinicopathologic presentations. Surprisingly, unlike its benign counterpart eccrine poroma, eccrine porocarcinoma is seldom found in areas with a high density of eccrine sweat glands, like the palms or soles. Instead, eccrine porocarcinoma frequently occurs on the lower extremities, trunk and abdomen, but also on the head, resembling various other skin tumors, as illustrated in the patients described herein. Observations: We report 5 cases of eccrine porocarcinoma of the head. All patients were initially diagnosed as having epidermal or melanocytic skin tumors. Only after histopathologic examination were they classified as eccrine porocarcinoma, showing features of epithelial tumors with abortive ductal differentiation. Characteristic clinical, histopathologic and immunohistochemical findings of eccrine porocarcinomas are illustrated. Conclusion: Eccrine porocarcinomas are potentially fatal adnexal malignancies, in which extensive metastatic dissemination may occur. Porocarcinomas are commonly overlooked, or misinterpreted as squamous or basal cell carcinomas as well as other common malignant and even benign skin tumors. Knowledge of the clinical pattern and histologic findings, therefore, is crucial for an early therapeutic intervention, which can reduce the risk of tumor recurrence and serious complications. Copyright (c) 2008 S. Karger AG, Basel

Faddeev Calculations of Proton-Deuteron Radiative Capture with Exchange Currents

pd capture processes at various energies have been analyzed based on solutions of 3N-Faddeev equations and using modern NN forces. The application of the Siegert theorem is compared to the explicit use of $\pi$- and $\rho$-like exchange currents connected to the AV18 NN interaction. Overall good agreement with cross sections and spin observables has been obtained but leaving room for improvement in some cases. Feasibility studies for 3NF's consistently included in the 3N continuum and the 3N bound state have been performed as well.Comment: Minor changes in notation, ps files for figure

Future Changes in Major Stratospheric Warmings in CCMI Models

Major stratospheric warmings (MSWs) are one of the most important phenomena of wintertime Arctic stratospheric variability. They consist of a warming of the Arctic stratosphere and a deceleration of the polar night jet, triggered by an anomalously high injection of tropospheric wave activity into the stratosphere. Due to the relevance and the impact of MSWs on the tropospheric circulation, several model studies have investigated their potential responses to climate change. However, a wide range of results has been obtained, extending from a future increase in the frequency of MSWs to a decrease. These discrepancies might be explained by different factors such as a competition of radiative and dynamical contributors with opposite effects on the Arctic polar vortex, biases of models to reproduce the related processes, or the metric chosen for the identification of MSWs. In this study, future changes in wintertime Arctic stratospheric variability are examined in order to obtaina more precise picture of future changes in the occurrence of MSWs. In particular, transient REFC2 simulations of different CCMs involved in the Chemistry Climate Model Initiative (CCMI) are used. These simulations extend from 1960 to 2100 and include forcings by halogens and greenhouse gases following the specifications of the CCMI-REF-C2 scenario. Sea surface temperatures (SSTs) and sea-ice distributions are either prescribed from coupled climate model integrations or calculated internally in the case of fully coupled atmosphere-ocean CCMs. Potential changes in the frequency and main characteristics of MSWs in the future are investigated with special focus on the dependence of the results on the criterion for the identification of MSWs and the tropospheric forcing of these phenomena

Tropospheric jet response to Antarctic ozone depletion: An update with Chemistry-Climate Model Initiative (CCMI) models

The Southern Hemisphere (SH) zonal-mean circulation change in response to Antarctic ozone depletion is re-visited by examining a set of the latest model simulations archived for the Chemistry-Climate Model Initiative (CCMI) project. All models reasonably well reproduce Antarctic ozone depletion in the late 20th century. The related SH-summer circulation changes, such as a poleward intensification of westerly jet and a poleward expansion of the Hadley cell, are also well captured. All experiments exhibit quantitatively the same multi-model mean trend, irrespective of whether the ocean is coupled or prescribed. Results are also quantitatively similar to those derived from the Coupled Model Intercomparison Project phase 5 (CMIP5) high-top model simulations in which the stratospheric ozone is mostly prescribed with monthly- and zonally-averaged values. These results suggest that the ozone-hole-induced SH-summer circulation changes are robust across the models irrespective of the specific chemistry-atmosphere-ocean coupling

Case of relapsed AIDS-related plasmablastic lymphoma treated with autologous stem cell transplantation and highly active antiretroviral therapy

Plasmablastic lymphoma is a rare and aggressive malignancy strongly associated with HIV infection. The refractory/relapsed disease rate is high, and the survival rate is characteristically poor. There are no satisfactory salvage regimens for relapsed cases. We successfully performed autologous stem cell transplantation using a regimen consisting of MCNU (ranimustine), etoposide, cytarabine, and melphalan in a Japanese patient with relapsed AIDS-related plasmablastic lymphoma of the oral cavity. Highly active antiretroviral therapy continued during the therapy. Therapy-related toxicity was tolerable, and a total of 40 Gy of irradiation was administered after autologous stem cell transplantation. The patient has remained in complete remission for 16 months since transplantation

Chemistry–climate model simulations of twenty-first century stratospheric climate and circulation changes

The response of stratospheric climate and circulation to increasing amounts of greenhouse gases (GHGs) and ozone recovery in the twenty-first century is analyzed in simulations of 11 chemistry–climate models using near-identical forcings and experimental setup. In addition to an overall global cooling of the stratosphere in the simulations (0.59 6 0.07 K decade21 at 10 hPa), ozone recovery causes a warming of the Southern Hemisphere polar lower stratosphere in summer with enhanced cooling above. The rate of warming correlates with the rate of ozone recovery projected by the models and, on average, changes from 0.8 to 0.48 Kdecade21 at 100 hPa as the rate of recovery declines from the first to the second half of the century. In the winter northern polar lower stratosphere the increased radiative cooling from the growing abundance of GHGs is, in most models, balanced by adiabatic warming from stronger polar downwelling. In the Antarctic lower stratosphere the models simulate an increase in low temperature extremes required for polar stratospheric cloud (PSC) formation, but the positive trend is decreasing over the twenty-first century in all models. In the Arctic, none of the models simulates a statistically significant increase in Arctic PSCs throughout the twenty-first century. The subtropical jets accelerate in response to climate change and the ozone recovery produces awestward acceleration of the lower-stratosphericwind over theAntarctic during summer, though this response is sensitive to the rate of recovery projected by the models. There is a strengthening of the Brewer–Dobson circulation throughout the depth of the stratosphere, which reduces the mean age of air nearly everywhere at a rate of about 0.05 yr decade21 in those models with this diagnostic. On average, the annual mean tropical upwelling in the lower stratosphere (;70 hPa) increases by almost 2% decade21, with 59% of this trend forced by the parameterized orographic gravity wave drag in the models. This is a consequence of the eastward acceleration of the subtropical jets, which increases the upward flux of (parameterized) momentum reaching the lower stratosphere in these latitudes