СИНТЕЗ ФУНКЦИОНАЛЬНО ЗАМЕЩЕННЫХ ИЗОКСАЗОЛИЛ(ИЗОТИАЗОЛИЛ)ТРИАЗОЛОВ, ОКСАДИАЗОЛОВ И ТИАДИАЗОЛОВ - НОВЫХ БИОАКТИВНЫХ СУБСТАНЦИЙ

Functionally substituted isoxazolyl(isothiazolyl)triazoles, oxadiazoles and thiadiazoles were synthesized on the basis of reactive 5-arylisoxazoles and 4,5-dichloroisothiazoles by successive transformations at position 3 of the heterocycle. The resulting compounds have a high potential of biological activity.На основе реакционноспособных 5-арилизоксазолов и 4,5-дихлоризотиазолов путем последовательных превращений по положению 3 гетероцикла синтезированы функционально замещенные изоксазолил(изотиазолил)триазолы, оксадиазолы и тиадиазолы. Полученные соединения обладают высоким потенциалом биологической активности

Synthesis of 5-azolyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 5-azolyl-1,3,4-thiadiazol-2-amines based on derivatives of 5-arylisoxazole-3-carboxylic and 4,5-dichloroisothiazole-3-carboxylic acids

[Figure not available: see fulltext.] 2-Mercapto-1,3,4-triazoles and 2-amino-1,3,4-thiadiazoles were synthesized by successive transformations of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids and their derivatives. The amino group of 5-(4,5-dichloroisothiazol-3-yl)-1,3,4-thiadiazol-2-amine was acylated with 5-phenylisoxazole-3-carboxylic acid chloride. Simple approaches to the preparation of previously unknown heterocyclic assemblies containing two or three azole rings with a high potential for biological activity are described. © 2021, Springer Science+Business Media, LLC, part of Springer Nature

Investigation of the compressed baryonic matter at the GSI accelerator complex

The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (√sNN = 2-4.9 GeV) is to discover fundamental properties of QCD matter, namely, the equation-of-state at high density as it is expected to occur in the core of neutron stars, effects of chiral symmetry, and the phase structure at large baryon-chemical potentials (μB ≥ 500 MeV).We are focusing here on the contribution of JINR to the CBM experiment: design of the superconducting dipole magnet; manufacture of the straw and micro-strip silicon detectors, participation in the data taking and analysis algorithms and physics program.* Dedicated to the memory of Prof. Yu.V. Zanevsky and Prof. V.D. Peshekhono

Investigation of the compressed baryonic matter at the GSI accelerator complex*

The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (√sNN = 2-4.9 GeV) is to discover fundamental properties of QCD matter, namely, the equation-of-state at high density as it is expected to occur in the core of neutron stars, effects of chiral symmetry, and the phase structure at large baryon-chemical potentials (μB ≥ 500 MeV). We are focusing here on the contribution of JINR to the CBM experiment: design of the superconducting dipole magnet; manufacture of the straw and micro-strip silicon detectors, participation in the data taking and analysis algorithms and physics program