151 research outputs found
FEATURES OF INVULERSE PENDULUM MODEL USING HIGH-SPEED RUN-UP IN JAVELIN THROWING
This study uses three-dimensional motion analysis to determine features of the throwing motion in male javelin throwers. Run-up speeds were compared and features of the inverse pendulum model were determined using three-dimensional motion analysis. The results showed that run-up speed correlated with throwing distance. As run-up speed increased, the pendulum angle at L-on enlarged and tilted backwards (p < .01) after the width of the pendulum increased during the double-support phase. We presumed that the enlarged backward tilt converted a large amount of energy to increase the speed of run-up at L-on
Role of bias and tunneling asymmetries in nonlinear Fermi-liquid transport through an SU() quantum dot
We study how bias and tunneling asymmetries affect nonlinear current through
a quantum dot with discrete levels in the Fermi liquid regime, using an
exact low-energy expansion of the current derived up to terms of order
with respect to the bias voltage. The expansion coefficients are described in
terms of the phase shift, the linear susceptibilities, and the three-body
correlation functions, defined with respect to the equilibrium ground state of
the Anderson impurity model. In particular, the three-body correlations play an
essential role in the order term, and their coupling to the nonlinear
current depends crucially on the bias and tunnel asymmetries. The number of
independent components of the three-body correlation functions increases with
the internal degrees of the quantum dots, and it gives a variety in the
low-energy transport. We calculate the correlation functions over a wide range
of electron fillings of the Anderson impurity model with the SU() internal
symmetry, using the numerical renormalization group. We find that the order
nonlinear current through the SU() Kondo state, which occurs at
electron fillings of and for strong Coulomb interactions,
significantly varies with the three-body contributions as tunnel asymmetries
increase. Furthermore, in the valence fluctuation regime toward the empty or
fully occupied impurity state, a sharp peak emerges in the coefficient of
current in the case at which bias and tunneling asymmetries cooperatively
enhance the charge transfer from one of the electrodes.Comment: 18 pages, 13 figures. Typos have been correcte
Chemical composition and their characteristics of shallow ice cores drilled at Dome Fuji, East Antarctica
第3回極域科学シンポジウム 横断セッション「海・陸・氷床から探る後期新生代の南極寒冷圏環境変動」11月27日(火) 国立国語研究所 2階講
Effect of Application of Subcutaneous Suction Drainage with Subcuticular Sutures for Wound Closure on the Incidence of Incisional Surgical Site Infection following Elective General Abdominal Surgery : A Randomized Controlled Trial
Article信州医学雑誌 63(2):91-101 (2015)journal articl
Impaired degradation followed by enhanced recycling of epidermal growth factor receptor caused by hypo-phosphorylation of tyrosine 1045 in RBE cells
信州大学博士(医学)・学位論文・平成24年6月11日授与(甲第929号)・桂安萍Background: Since cholangiocarcinoma has a poor prognosis, several epidermal growth factor receptor (EGFR)-targeted therapies with antibody or small molecule inhibitor treatment have been proposed. However, their effect remains limited. The present study sought to understand the molecular genetic characteristics of cholangiocarcinoma related to EGFR, with emphasis on its degradation and recycling. Methods: We evaluated EGFR expression and colocalization by immunoblotting and immunofluorescence, cell surface EGFR expression by fluorescence-activated cell sorting (FACS), and EGFR ubiquitination and protein binding by immunoprecipitation in the human cholangiocarcinoma RBE and immortalized cholangiocyte MMNK-1 cell lines. Monensin treatment and Rab11a depletion by siRNA were adopted for inhibition of EGFR recycling. Results: Upon stimulation with EGF, ligand-induced EGFR degradation was impaired and the expression of phospho-tyrosine 1068 and phospho-p44/42 MAPK was sustained in RBE cells as compared with MMNK-1 cells. In RBE cells, the process of EGFR sorting for lysosomal degradation was blocked at the early endosome stage, and non-degradated EGFR was recycled to the cell surface. A disrupted association between EGFR and the E3 ubiquitin ligase c-Cbl, as well as hypo-phosphorylation of EGFR at tyrosine 1045 (Tyr1045), were also observed in RBE cells. Conclusion: In RBE cells, up-regulation of EGFR Tyr1045 phosphorylation is a potentially useful molecular alteration in EGFR-targeted therapy. The combination of molecular-targeted therapy determined by the characteristics of individual EGFR phosphorylation events and EGFR recycling inhibition show promise in future treatments of cholangiocarcinoma.ArticleBMC Cancer. 2012, 12:179journal articl
Adjuvant Chemotherapy with Gemcitabine for Resected Biliary Tract Cancer: A Single-Arm Phase 2 Study
Article信州医学雑誌 65(2): 99-111(2017)journal articl
Laparoscopic Splenectomy Using a Low-pressure Pneumoperitoneum for the Treatment of Immune Thrombocytopenic Purpura During Pregnancy : A Case Report
Article信州医学雑誌 62(6):441-446(2014)journal articl
An Initial Case Report of a Laparoscopic Spleen-Preserving Distal Pancreatectomy for a Patent with a Pancreatic Metastasis of Malignant Melanoma
Article信州医学雑誌 63(1):19-24(2015)journal articl
Thermal conductivity of uranium dioxide by nonequilibrium Molecular dynamics simulation
金沢大学理学部The thermal conductivity of UO2 pellet, which is used as nuclear fuel, was calculated using the nonequilibrium classical molecular dynamics method by Evans and Morriss. The result of calculation from 300–3000 K obtained presents the same tendency as experiments below 2400 K. Above 2400 K, a different tendency was observed in which the electron conduction was not negligible. The thermal conductivity using the nonequilibrium molecular dynamics method was calculated with about 1/10 number of simulation steps compared with the equilibrium molecular dynamics simulation. It was found that the nonequilibrium molecular dynamics simulation is quite effective
Densification of layered firn of the ice sheet at Dome Fuji, Antarctica
第6回極域科学シンポジウム[OM] 極域気水圏11月16日(月) 国立極地研究所1階交流アトリウ
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