ミズ カンキョウ オセン ブッシツ ノ ドウタイ ヒョウカ ケンキュウ キョテン ノ コウチク

本拠点形成では、地球規模での省資源･持続･循環社会の実現において中核となる環境科学の分野で画期的な貢献をするために、熊本大学の立地条件に配慮し、緊急性の高い水環境汚染物質の動態評価研究拠点の構築を目指す。とくに、環境悪化の原因とメカニズムが不明のまま疲弊状態にある有明･八代海の再生修復への貢献を念頭に置き、環境ホルモンなどの環境汚染物質の生物モニタリング科学創成、沿岸域における栄養塩除去などに有効な環境汚染物質のバイオ・レミディエーションの科学技術研究の展開、陸水と海水に跨る沿岸域水環境の計測･解析･評価手法の高度化と応用、微量で多様な環境汚染物質の高精度定量手法の開発と応用などの先導的研究を推進する。また、これらの研究を通じて総合的な研究能力と高度な洞察力を有する創造性豊かな人材を育成するとともに、環境産業創成に貢献する

ミズ カンキョウ オセン ブッシツ ノ ドウタイ ヒョウカ ケンキュウ キョテン ノ コウチク

本拠点形成では、地球規模での省資源･持続･循環社会の実現において中核となる環境科学の分野で画期的な貢献をするために、熊本大学の立地条件に配慮し、緊急性の高い水環境汚染物質の動態評価研究拠点の構築を目指す。とくに、環境悪化の原因とメカニズムが不明のまま疲弊状態にある有明･八代海の再生修復への貢献を念頭に置き、環境ホルモンなどの環境汚染物質の生物モニタリング科学創成、沿岸域における栄養塩除去などに有効な環境汚染物質のバイオ・レミディエーションの科学技術研究の展開、陸水と海水に跨る沿岸域水環境の計測･解析･評価手法の高度化と応用、微量で多様な環境汚染物質の高精度定量手法の開発と応用などの先導的研究を推進する。また、これらの研究を通じて総合的な研究能力と高度な洞察力を有する創造性豊かな人材を育成するとともに、環境産業創成に貢献する

Symptomatic periesophageal vagal nerve injury by different energy sources during atrial fibrillation ablation

BackgroundSymptomatic gastric hypomotility (SGH) is a rare but major complication of atrial fibrillation (AF) ablation, but data on this are scarce.ObjectiveWe compared the clinical course of SGH occurring with different energy sources.MethodsThis multicenter study retrospectively collected the characteristics and clinical outcomes of patients with SGH after AF ablation.ResultsThe data of 93 patients (67.0 ± 11.2 years, 68 men, 52 paroxysmal AF) with SGH after AF ablation were collected from 23 cardiovascular centers. Left atrial (LA) ablation sets included pulmonary vein isolation (PVI) alone, a PVI plus a roof-line, and an LA posterior wall isolation in 42 (45.2%), 11 (11.8%), and 40 (43.0%) patients, respectively. LA ablation was performed by radiofrequency ablation, cryoballoon ablation, or both in 38 (40.8%), 38 (40.8%), and 17 (18.3%) patients, respectively. SGH diagnoses were confirmed at 2 (1–4) days post-procedure, and 28 (30.1%) patients required re-hospitalizations. Fasting was required in 81 (92.0%) patients for 4 (2.5–5) days; the total hospitalization duration was 11 [7–19.8] days. After conservative treatment, symptoms disappeared in 22.3% of patients at 1 month, 48.9% at 2 months, 57.6% at 3 months, 84.6% at 6 months, and 89.7% at 12 months, however, one patient required surgery after radiofrequency ablation. Symptoms persisted for >1-year post-procedure in 7 patients. The outcomes were similar regardless of the energy source and LA lesion set.ConclusionsThe clinical course of SGH was similar regardless of the energy source. The diagnosis was often delayed, and most recovered within 6 months, yet could persist for over 1 year in 10%

Prognostic nutritional index of early post-pembrolizumab therapy predicts long-term survival in patients with advanced urothelial carcinoma

Pembrolizumab has been widely used to treat advanced urothelial carcinoma that has progressed after first-line platinum-based chemotherapy. Because its clinical benefits are limited, biomarkers that can predict a good response to pembrolizumab are required. The prognostic nutritional index (PNI), calculated using the serum albumin level and peripheral lymphocyte count, has been evaluated as a predictive biomarker in cancer immunotherapy. The present study investigated the application of PNI as a predictive biomarker for pembrolizumab response in patients with advanced urothelial cancer. A retrospective study was conducted on 34 patients treated with pembrolizumab at Shiga University of Medical Science Hospital between January 2018 and July 2022. The posttreatment PNI (post-PNI) was calculated within 2 months of starting pembrolizumab. The present study investigated the association between post-PNI and objective response, overall survival (OS) and progression-free survival (PFS). The patient cohort was stratified into two categories, high and low post-PNI groups, with a cutoff value of post-PNI at 40. The higher post-PNI group demonstrated a better disease control rate than the lower post-PNI group (complete response + partial response + stable disease, 75 vs. 21%, P=0.004). Regarding median OS, the higher post-PNI group exhibited a significantly longer survival time than the lower post-PNI group (23.1 vs. 2.9 months, P<0.001). Similarly, the higher post-PNI group exhibited a significantly longer PFS than the lower post-PNI group (10.2 vs.1.9 months, P<0.001). Multivariate analysis showed that a higher post-PNI value was an independent predictor for OS (hazard ratio, 0.04; 95% confidence interval, 0.01-0.14; P<0.001) and PFS (hazard ratio, 0.12; 95% confidence interval, 0.04-0.35; P<0.001). The present study indicated that the post-PNI was a predictor of favorable clinical outcomes in patients treated with pembrolizumab for advanced urothelial carcinoma

ミズ カンキョウ オセン ブッシツ ノ ドウタイ ヒョウカ ケンキュウ キョテン ノ コウチク

本拠点形成では、地球規模での省資源･持続･循環社会の実現において中核となる環境科学の分野で画期的な貢献をするために、熊本大学の立地条件に配慮し、緊急性の高い水環境汚染物質の動態評価研究拠点の構築を目指す。とくに、環境悪化の原因とメカニズムが不明のまま疲弊状態にある有明･八代海の再生修復への貢献を念頭に置き、環境ホルモンなどの環境汚染物質の生物モニタリング科学創成、沿岸域における栄養塩除去などに有効な環境汚染物質のバイオ・レミディエーションの科学技術研究の展開、陸水と海水に跨る沿岸域水環境の計測･解析･評価手法の高度化と応用、微量で多様な環境汚染物質の高精度定量手法の開発と応用などの先導的研究を推進する。また、これらの研究を通じて総合的な研究能力と高度な洞察力を有する創造性豊かな人材を育成するとともに、環境産業創成に貢献する

ミズ カンキョウ オセン ブッシツ ノ ドウタイ ヒョウカ ケンキュウ キョテン ノ コウチク

本拠点形成では、地球規模での省資源･持続･循環社会の実現において中核となる環境科学の分野で画期的な貢献をするために、熊本大学の立地条件に配慮し、緊急性の高い水環境汚染物質の動態評価研究拠点の構築を目指す。とくに、環境悪化の原因とメカニズムが不明のまま疲弊状態にある有明･八代海の再生修復への貢献を念頭に置き、環境ホルモンなどの環境汚染物質の生物モニタリング科学創成、沿岸域における栄養塩除去などに有効な環境汚染物質のバイオ・レミディエーションの科学技術研究の展開、陸水と海水に跨る沿岸域水環境の計測･解析･評価手法の高度化と応用、微量で多様な環境汚染物質の高精度定量手法の開発と応用などの先導的研究を推進する。また、これらの研究を通じて総合的な研究能力と高度な洞察力を有する創造性豊かな人材を育成するとともに、環境産業創成に貢献する

Utility of radial endobronchial ultrasonography combined with transbronchial lung cryobiopsy in patients with diffuse parenchymal lung diseases: a multicentre prospective study

Background Radial endobronchial ultrasonography (R-EBUS) has been used in conjunction with transbronchial lung cryobiopsy (TBLC) to diagnose diffuse parenchymal lung disease (DPLD) and to decrease the risk of bleeding complications. The diagnostic utility of different R-EBUS signs, however, remains unknown.Objectives This study aimed to determine whether different R-EBUS signs could be used to more accurately diagnose DPLD and whether bronchial bleeding could be prevented with use of R-EBUS during TBLC.Method Eighty-seven patients with DPLD were included in this multicentre prospective study, with 49 patients undergoing R-EBUS. R-EBUS signals were characterised as displaying either dense or blizzard signs. Pathological confidence of specimens obtained from TBLC was compared between patients with dense versus blizzard signs, and severity of bronchial bleeding was determined based on whether R-EBUS was performed or not.Results All patients with dense signs on R-EBUS showed consolidation on high-resolution CT (HRCT) imaging. Pathological confidence of lung specimens was significantly higher in patients with dense signs versus those with blizzard signs (p&lt;0.01) and versus those who did not undergo R-EBUS (p&lt;0.05). Patients who underwent TBLC with R-EBUS were more likely to experience no or mild bronchial bleeding than patients who did not undergo R-EBUS (p&lt;0.01), with shorter procedure times (p&lt;0.01).Conclusions The dense R-EBUS sign corresponded with consolidation on HRCT. High-quality lung specimens may be obtainable when the dense sign is observed on R-EBUS, and R-EBUS combined with TBLC may reduce risk of bronchial bleeding and shorten procedure times