Whole genome sequencing of m. Tuberculosis strains in kazakhstan reveal genomic variants in genes coding pe/ppe protein family specific for mdr/xdr isolates

Worldwide in 2016, around 10.4 million people were diagnosed with TB among which 1.7 million died [1]. Despite the progress in decreasing the global incidence of drug-susceptible TB, multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the past decade led to decreased efficiency of chemotherapy. However, the rate of drug-resistant TB increases annually, especially multidrug-resistant TB (MDR TB) [1]

Beijing genotype is the most dominant genotype among clinical isolates of m.tuberculosis in Kazakhstan

Methods of genotyping of M. tuberculosis play important role in tuberculosis (TB) infection control. These techniques are used to detect or exclude laboratory errors, control recurrent cases and determine ways of TB transmission. Today, there are more than 10 methods of genotyping, MIRU-VNTR being one of the most widely used methods in the world

Gene expression and methylation profiles as a biomarker for human radiation exposure

Taking into account the fact that Kazakhstan is one of the world's leaders in uranium mining, and given the extent of the damage suffered as a result of the work on the Semipalatinsk nuclear test site, the general background radiation in some regions came under the influence of additional effects of chronic exposure to low doses of radiation, the study and search for new methods of dosimetry, as an integral part of the radiological protection of the population, is a priority for the state. The purpose of this study is the search for and development of potential biomarkers by assessing the impact if ionising radiation on gene expression and quantification of global methylation and hydroxymethylation of uranium industry workers