Crystal structure of 7-methoxy-1-{[(E)-2,6-dimethylphenylimino] (phenyl)methyl}-2-naphthol: Clarification of non-covalent bonding interactions on the basis of spatial organization of single molecular structure and the molecular alignments

Crystal structure of the title compound, 7-methoxy-1-{[(E)-2,6-dimethylphenylimino] (phenyl)methyl}-2-naphthol, which has N-aryl group instead of ketonic carbonyl group has been comparatively analysed with the precursor compound of 1-benzoyl-2-hydroxy-7-methoxynaphthalene. The distinct features in the molecular accumulation structures of title triarylimine compound and the precursor diaryl ketone demonstrate that the spatial organization of the former is mainly determined π-π stacking interaction and for the latter the non-classical hydrogen bondings govern the spatial organization. Besides both of the compounds show non-coplanaryl accumulation of aromatic rings molecular structure, the title compound has molecular core of imino group which attaches three aromatic rings of C-1-naphthyl, C-phenyl, and N-phenyl stems of nearly perpendicular alignment of each aryl groups to residual two aryl ones respectively, giving highly congested circumstance at the inner site of molecules. On the other hand, the precursor aromatic ketone molecule has relatively large space compared to title compound, enabling conformational flexibility to some extent within restriction of maintaining non-coplanar organization. The molecules of the precursor compound in crystal are stabilized by a number of non-covalent bonding interactions, mainly by non-classical hydrogen bondings. The achievement stabilization contributed a number of non-classical hydrogen bonding is considered to be due to the inner-molecular motility of single molecular structure. Contrarily, the congested inner-molecular situation of title compound makes largely rigid molecular conformation, which affords at the same time exposure of three aromatic planes outside the molecular core. The single molecular organization permits π-π stacking interaction stabilization instead of formation of a number of weak interactions. Thus, the governing factors for the distinct feature of the single molecular and the accumulation structures of title compound and the precursor are interpreted from the viewpoint of predominantly effective intermolecular interaction, a strong π-π stacking interaction or sum of weak non-classical hydrogen bondings, determined by the inner-molecular congestive conditions directly affects the inner-molecular motility

Interview study on the process of social participation by former street children and child laborers in India <Article>

This study examined how young adults in India, who were former street children and/or child laborers, were struggling to become independent and find jobs with the support of NGOs. We conducted interviews with young adults and NGO staff, and also observed activities conducted by NGOs in India. Some young adults successfully obtained technical skills and applied for jobs with the support of NGOs. However, difficulties in admitting their own mental problems, and not being completely understood by NGO staff, made it difficult for these young people to adapt to the mainstream Indian society. Our results suggest that former street children and child laborers need continuous psychological support, in order to facilitate their participation in society as independent adults.本研究は広島大学校友会学生による学術研究への研究資金助成を受けて行われた

The influence of intention in conflict on the interventions and apologies of children in virtual conflict situations

To examine the influence of intention in conflict on the interventions and apologies of children in virtual conflict situations, we conducted experiments with 3- and 5-year-old girls and boys. Our findings suggest that the conflict's intention reflected the interventions, apologies and reasons. An age difference was observed. Five-year-old children gave more effective answers to resolve conflict situations, using both interventions and apologies more than the 3 year-old children. When asked about such interventions and apologies, many 5-year-old children suggested reasons that were focused on the victim's feelings and accepted responsibility for the conflict or expressed a sense of guilt. In contrast, many 3-year-olds decided their behaviors based on roles or evaluations of others. Furthermore, gender differences were observed Most of the girls selected an impartial intervention between victim and attacker; in contrast, many of the boys selected an intervention that supported only the victim. As an attacker, most girls answered apologetically. When questioned about such interventions and apologies, many girls made judgements of right and wrong themselves and accepted responsibility for the conflict or expressed a sense of guilt. In contrast, many of the boys decided their behaviors from the evaluations of others

Effects of mismatch of internal tempo and external tempo on walking and emotions <Article>

A music tempo that does not correspond with a walking tempo results in an experience of difficulty in walking and generates unpleasant internal feelings. It has been posited that walking tempo is an internal tempo and that music tempo is an external one. We evaluated how participants felt when their internal tempo did not correspond with their external tempo. We also studied their internal tempo's influence on their walking. Twenty undergraduate students participated in the experiment. They walked on a treadmill and adjusted the speed so as to walk at the most comfortable speed. Participants' pleasure, relaxation, and anxiety while walking with or without sounds of metronome, the tempo of which was 50, 90, 140, or 180 beats per minute, were evaluated by MCL-S.2 scale. Results showed that participants felt more pleasant and relaxed when their internal and external tempos were in agreement. Conversely, participants felt more anxious when the tempos did not correspond. Walk tempo did not significantly vary with the external metronome tempo. Some factors which obscure the effects of external tempo are discussed

The influence of attentional bias of social anxiety on anxiety in public speaking situations

The current study sought to investigate the relationship between the focus of attention and state anxiety during a public speaking situation involving social anxiety . In a preliminary investigation, undergraduate students responded to a questionnaire based on the Two-dimensional Social Phobic Tendency and Narcissistic Personality Scale-Short version (TENS-S). A previous study using the TENS-S suggested that social anxiety could be divided into two subtypes (high anthropophobic tendency and high narcissistic personality, or high anthropophobic tendency and low narcissistic personality). The high anthropophobic tendency and high narcissistic personality group (HH group) was predicted to exhibit increased anxiety with self-focused attention and other-focused attention. The high anthropophobic tendency and low narcissistic personality group (HL group) was predicted to exhibit increased anxiety with other-focused attention. After screening, 30 undergraduate students were divided into one of three groups based on their questionnaire scores; HH group (n = 8), HL group (n = 9), and low social anxiety group (n = 12). Participants were asked to undertake a speech task to increase state anxiety. Following the speech task, participants rated the direction of changes in attention and the level of state anxiety. The results indicated that self-focused attention and other-focused attention were facilitated in public speaking situations

Cognitive Behavior Therapy and "Total Conviction"

The purposes of the present article are to explain an outline about cognitive behavior therapy (CBT) and "total conviction". The effectiveness of CBT has been demonstrated by studies conducted in a number of countries. As a predecessor of CBT, cognitive therapy proposed the importance of examining cognitive factors such as "automatic thought" and "schemas". CBT supposes that efficient treatment is accomplished by restructuring these constructs. However, there is confusion regarding the understanding of cognitive modification and the difficulty of accurately capturing cognitive modification in a clinical situation. Negative effects, such as worsening of the therapeutic relationship and the occurrence of anxiety and depression, have been reported in some cases where a cognitive approach was used with a patient. The current study suggests that some therapists use a perspective of "total conviction" to solve these problems. A previous study revealed that "total conviction" is a cognitive factor that can enable this behavior. However, previous studies of "total conviction" involve several limitations. Finally, we discuss the potential future directions of research on "total conviction". We suggest that further study of "total conviction" may enable replication of the treatment process of CBT

A preliminary investigation of long-term cognitive-behavioral predictive factors of depression in high school students.

Preventative interventions for depression in high school students are often targeted to cognitive-behavioral factors, such as maladaptive cogitation, inadequate social skills, or rumination. Although previous research has revealed that cognitive-behavioral factors are important for reducing depression, there is little evidence regarding the factors that most effectively predict increased depression in high school students. Therefore, we sought to identify the most predictable long-term cognitive-behavioral factors in depression by comparing these three factors. We conducted a 1-year two-wave longitudinal questionnaire survey with 51 high school students. The results revealed that only rumination predicted depression after 1 year, but the predictive effect was relatively small. Moreover, maladaptive cognition and social skills, which are usually targeted by prevention intervention, did not account for increased depression. The current findings suggest that it would be valuable for future studies to further clarify which factors affect depression among high school students

Effort for solving difficult problems among university students: Why can they keep making efforts?

University students experience many difficult problems that can lead to mental illness. However, many students can solve these problems by making efforts to confront them. Previous research has showed that social support, generalized self-efficacy, future time perspective, task motivation, and difficulty of the problem are related to solving difficult problems; moreover, some of these factors are connected to each other. In this research, the primary aim was to identify the process of making an effort to confront problems, for which I have developed a hypothetical model. Additionally, students grow up in the four years of their university life. The second aim was to identify the difference between grades in the hypothesized process model. The questionnaire was completed by 399 students (96 freshmen, 95 sophomores, 89 juniors, 69 seniors, and 50 graduates). Covariance structure analysis was performed for the entire sample. The result supported the hypothetical model of making efforts, but some new connections were found. In other words, all psychological factors were complexly connected to each other. Then, I performed covariance structure analysis for my hypothetical model for each grade and compared the models. The results of this comparison showed that the strength of correlation of all factors were different across the grades. Although the factor of future time perspective had no effect on the model for the 1st grade, the effect increased with subsequent grades. Additionally, the effect of the factor of generalized self-efficacy increased with each grade

Crystal structure of 1-benzoyl-2,7-dimethoxy-8-(3,5-dimethylbenzoyl) naphthalene: Head-to-head fashioned molecular motif for accumulating weak non-classical hydrogen bonds

Title compound, 1-benzoyl-2,7-dimethoxy-8-(3,5-dimethylbenzoyl)naphthalene, an unsymmetrically substituted aromatic diketone compound having non-coplanarly accumulated aromatic rings structure, has been synthesized and its crystal structure has been determined by X-ray crystallography. The asymmetric unit of title compound contains two independent conformers. For each conformer, the two aroyl groups are non-coplanarly situated against the naphthalene ring plane and oriented in an opposite direction. The 3,5-dimethylbenzoyl group leans more than the non-substituted benzoyl group on the other peri-position of the naphthalene ring. The characteristics in the single molecular crystal structure of this unsymmetrical compound show unique relationship with two symmetrically substituted homologues, namely 1,8-dibenzoyl-2,7-dimethoxynaphthalene and 2,7-dimethoxy-1,8-bis(3,5-dimethylbenzoyl) naphthalene. Dihedral angles between 3,5-dimethylbenzene ring and naphthalene ring of 2,7-dimethoxy-1,8-bis(3,5-dimethylbenzoyl)naphthalene are larger than those between benzene ring and naphthalene ring of 1,8-dibenzoyl-2,7-dimethoxynaphthalene. Dihedral angle between 3,5-dimethylbenzoyl group and naphthalene ring in title compound is close to those of symmetrical homologue having two 3,5-dimethylbenzoyl groups. In the similar manner, dihedral angle between non-substituted benzoyl group and naphthalene ring in title compound is also close to those of symmetrical homologue bearing two non-substituted benzoyl groups. On the other hand, the crystal packing of title compound has rather similar feature with 2,7-dimethoxy-1,8-bis(3,5-dimethylbenzoyl)naphthalene. Two compounds have common crystalline molecular structural motif of head-to-head fashioned intermolecular interaction of 3,5-dimethylbenzoyl moieties. It is interpreted that the interactions between (sp3)C–H and π orbital preferentially govern the molecular packing motif. Molecular structure feature of title compound and the symmetrically 3,5-dimethylbenzoylated homologue strongly manifests that accumulation of weak non-classical hydrogen bonds play a crucial role in determination of the crystal packing rather than sole function of stronger non-classical hydrogen bond and π…π stacking

Absence of in vivo mutagenicity of multi-walled carbon nanotubes in single intratracheal instillation study using F344 gpt delta rats

Abstract Introduction It is known that fibrous particles of micrometer length, such as carbon nanotubes, which have same dimensions as asbestos, are carcinogenic. Carcinogenicity of nanomaterials is strongly related to inflammatory reactions; however, the genotoxicity mechanism(s) is unclear. Indeed, inconsistent results on genotoxicity of multi-walled carbon nanotubes (MWCNTs) have been shown in several reports. Therefore, we analyzed the in vivo genotoxicity induced by an intratracheal instillation of straight MWCNTs in rats using a different test system\u2014the Pig-a gene mutation assay\u2014that can reflect the genotoxicity occurring in the bone marrow. Since lungs were directly exposed to MWCNTs upon intratracheal instillation, we also performed the gpt assay using the lungs. Findings We detected no significant differences in Pig-a mutant frequencies (MFs) between the MWCNT-treated and control rats. Additionally, we detected no significant differences in gpt MFs in the lung between the MWCNT-treated and control rats. Conclusions Our findings indicated that a single intratracheal instillation of MWCNTs was non-mutagenic to both the bone marrow and lung of rats