6 research outputs found
Low-temperature sterilization of wrapped materials using flexible sheet-type dielectric barrier discharge
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Radiologic assessment of a self-shield with boron-containing water for a compact medical cyclotron
Comparison of neutron fluxes in an 18-MeV unshielded cyclotron room and a 16.5-MeV self-shielded cyclotron room
In vivo reprogramming of wound-resident cells generates skin epithelial tissue
Large cutaneous ulcers are, in severe cases, life threatening(1,2). As the global population ages, non-healing ulcers are becoming increasingly common(1,2). Treatment currently requires the transplantation of pre-existing epithelial components, such as skin grafts, or therapy using cultured cells(2). Here we develop alternative supplies of epidermal coverage for the treatment of these kinds of wounds. We generated expandable epithelial tissues using in vivo reprogramming of wound-resident mesenchymal cells. Transduction of four transcription factors that specify the skin-cell lineage enabled efficient and rapid de novo epithelialization from the surface of cutaneous ulcers in mice. Our findings may provide a new therapeutic avenue for treating skin wounds and could be extended to other disease situations in which tissue homeostasis and repair are impaired