Comprehensive and Rapid Real-Time PCR Analysis of 21 Foodborne Outbreaks

A set of four duplex SYBR Green I PCR (SG-PCR) assay combined with DNA extraction using QIAamp DNA Stool Mini kit was evaluated for the detection of foodborne bacteria from 21 foodborne outbreaks. The causative pathogens were detected in almost all cases in 2 hours or less. The first run was for the detection of 8 main foodborne pathogens in 5 stool specimens within 2 hours and the second run was for the detection of other unusual suspect pathogens within a further 45 minutes. After 2 to 4 days, the causative agents were isolated and identified. The results proved that for comprehensive and rapid molecular diagnosis in foodborne outbreaks, Duplex SG-PCR assay is not only very useful, but is also economically viable for one-step differentiation of causative pathogens in fecal specimens obtained from symptomatic patients. This then allows for effective diagnosis and management of foodborne outbreaks

Induction of Tumor-specific T Cell Immunity by Anti-DR5 Antibody Therapy

Because tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in tumor cells and plays a critical role in tumor surveillance, its receptor is an attractive target for antibody-mediated tumor therapy. Here we report that a monoclonal antibody (mAb) against the mouse TRAIL receptor, DR5, exhibited potent antitumor effects against TRAIL-sensitive tumor cells in vivo by recruiting Fc receptor–expressing innate immune cells, with no apparent systemic toxicity. Administration of the agonistic anti-DR5 mAb also significantly inhibited experimental and spontaneous tumor metastases. Notably, the anti-DR5 mAb-mediated tumor rejection by innate immune cells efficiently evoked tumor-specific T cell immunity that could also eradicate TRAIL-resistant variants. These results suggested that the antibody-based therapy targeting DR5 is an efficient strategy not only to eliminate TRAIL-sensitive tumor cells, but also to induce tumor-specific T cell memory that affords a long-term protection from tumor recurrence

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写真ありテーマ展示 : 平和を考える : 平和をつくりだすためにPOPコンテスト作品展示選書ツアーに行ってきました！ : 今フェリス生が一番読みたい本展示読プロ活動紹介「私たちの活動を紹介します」展

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写真あり大学祭の展示 : 秋葉祐子(図書館)ワークショップ しおり作り : 有馬梨咲(国際交流学科

Improved survival of gastric cancer with tumour Epstein–Barr virus positivity: an international pooled analysis

About 9% of gastric carcinomas have Epstein–Barr virus (EBV) in the tumour cells, but it is unclear whether viral presence influences clinical progression. We therefore examined a large multicentre case series for the association of tumour EBV status with survival after gastric cancer diagnosis, accounting for surgical stage and other prognostic factors

2015年度読書運動プロジェクト活動報告書

活動資料 p.(1)～p.(5)はじめに : 藤本 朝巳 p.1新入生勧誘イベント : 中藤 祥子 p.2読書会 : 匿名、森園 佳子、藏田 香織 p.3-p.5コンテスト・コンクール : 森園 佳子 p.6-p.7展示 : 秋葉 祐子 p.8-p.10コラボランチ : 秋葉 祐子 p.11選書ツアーとPOP講座 : 匿名 p.12文学散歩 : 吉満 みなみ p.13大学祭 : 小根山 桃子、今井 舞菜 p.14-p.16高校訪問 : 森園 佳子 p.17読み聞かせレッスン : 森園 佳子 p.18サマースクールプログラム朗読発表 : 鈴木 珠友 p.19小学校朗読会 : 森園 佳子 p.20朗読会 : 森園 佳子、阿部 果鈴 p.21-p.22朗読チームの活動を振り返って : 高橋 里奈、匿名 p.23-p.24プロフィール p.25-p.31おわりに : 森園 佳子 p.32写真あり表あ