The Effects of Montelukast on Antioxidant Enzymes and Proinflammatory Cytokines on the Heart, Liver, Lungs, and Kidneys in a Rat Model of Cecal Ligation and Puncture–Induced Sepsis

We investigated the potential protective effects of montelukast (MLK) on cecal ligation and puncture (CLP)–induced tissue injury in vital organs — liver, heart, kidneys, and especially lungs — through inhibition of the proinflammatory cytokine response and the generation of reactive oxygen species (ROS) in rats. The rat groups were (1) a 10-mg/kg MLK-treated CLP group; (2) a 20-mg/kg MLK-treated CLP group; (3) a 20-mg/kg MLK-treated, sham-operated group; (4) a CLP control group; and (5) a sham-operated control group. MLK treatment significantly decreased proinflammatory (tumor necrosis factor-alpha, interleukin-6) cytokine levels following CLP. The lipid peroxide level increased in the lung, heart, liver, and kidney tissues after CLP-induced sepsis, and myeloperoxidase activity increased in the lung, heart, and liver tissues. MLK attenuated this elevation in all tissues except the kidney, dose dependently. The glutathione levels and superoxide dismutase activity were significantly increased in the lung, liver, and kidney tissues after MLK treatment. MLK treatment after CLP also potentially reduced mortality. The lung and kidney tissues were the most protected by MLK under sepsis conditions. We can suggest that MLK reverses the systemic inflammatory reaction to polymicrobial sepsis and thereby reduces multiple organ failure

Evaluation Of Renal Transplant Scintigraphy In Diagnosis Of Urinary Leakage

31st Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) -- OCT 13-17, 2018 -- Dusseldorf, GERMANYWOS: 000449266203066European Assoc Nucl Me

Contribution of SPECT/CT to Evaluate Urinary Leakage Suspicion in Renal Transplant Patients

WOS: 000444969500012PubMed ID: 30059433It is known that renal scintigraphy is the best imaging modality in the diagnosis of urinary leakage. Usually, only planar images are diagnostic but sometimes they are unclear when urinoma is small and adjacent to kidney or bladder. In other respects, planar images can be false-positive in the case of increased blood flow of abdominal wall. We suggested using SPECT/CT in differential diagnosis. An atlas of SPECT/CT is presented, which includes 3 cases that urinoma was diagnosed by SPECT/CT, which were unclear on planar images, and one case that urinary leakage suspicion on planar image was ruled out by SPECT/CT

Complications of Circumcision in Childhood and Preventive Strategies

Circumcision is the most common surgical procedure applied worldwide. Besides the medical necessities, it is also common due to religious and cultural reasons. The frequent performance of this surgical procedure increases the importance of the management of the complications arising during/after the operation. In our country performing this procedure under the improper conditions especially by non-medical persons or inexperienced operators increases the likelihood of complications, which sometimes causes non-recoverable tissue and organ loss. The persons performing this surgical procedure must be well acquainted with the complications which may arise during/after a circumcision procedure. For this reason, the possible complications regarding a circumcision procedure should be classified. Within this context, the required suggestions are presented in this article to reduce the complications to a minimal level. [TAF Prev Med Bull 2011; 10(5.000): 605-610

The Contributions of SPECT-CT to Planar Splenic Scintigraphy Using Tc-99m-Labeled Heat-Denatured Red Blood Cells

Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) -- OCT 18-22, 2014 -- Gothenburg, SWEDENWOS: 000348841901150European Assoc Nucl Me

Comparison of Renal Transplant Scintigraphy With Renal Resistance Index for Prediction of Early Graft Dysfunction and Evaluation of Acute Tubular Necrosis and Acute Rejection

WOS: 000330356100010PubMed ID: 24152633Purpose: We discuss whether resistance index (RI) and renal scintigraphy obtained within 48 hours after operation could predict the early graft dysfunction. We also aimed to assess the uses of scintigraphy and RI in diagnosis of acute rejection (AR) and acute tubular necrosis (ATN). Methods: A total of 153 studies were performed in 109 patients. T-1/2 of perfusion peak, perfusion curve grades, and accumulation index (R20/3) were used as scintigraphic parameters. Baseline studies obtained within 48 hours after transplantation were evaluated for prediction of early graft dysfunction. All data were then assessed for specific diagnosis. Results: Scintigraphic parameters were significantly higher in patients with delayed graft function (DGF) and slow graft function (SGF) than in patients with immediate graft function. These parameters in DGF were also considerably different from those in SGF. The mean RI was significantly high in DGF, but there was no difference between SGF and immediate graft function. In diagnostic groups, the mean values of all tests were significantly different between normal functioning grafts and pathological grafts (ATN + AR). There was no significant difference between AR and ATN. However, renal scintigraphy has higher sensitivity and specificity for AR as compared with RI of Doppler ultrasonography (US). Conclusions: In predicting graft dysfunction and separating normal functioning graft from pathological graft (ATN + AR), renal scintigraphy provides more accurate information than Doppler US. Even though it is superior to Doppler US, renal scintigraphy also cannot reliably separate ATN from AR. The major advantage of renal scintigraphy is the early detection of reduced renal function