Lithium and anticholinergic combination to maintain a stable lithium plasma level

The effect of lithium and propantheline, an anticholinergic agent, combination on plasma and red blood cell (RBC) lithium levels was studied to test if this combination could maintain a stable plasma lithium level for a long-lasting period by delaying gastric emptying, in rabbits. There was a significant difference in plasma lithium levels between control and propantheline-administered groups (p < 0·01). The peak level seen in the second hour of lithium administration in the control group was not observed in the propantheline-administered group and a stable lithium level was maintained. It was suggested that a lithium and anticholinergic drug combination can be an alternative in eliminating the peak plasma levels of lithium and preventing the side-effects thought to be related to this factor. Copyright © 1994 John Wiley & Sons, Ltd

Lithium and Anticholinergic Combination To Maintain a Stable Lithium Plasma-Level

WOS: A1994NF19900004The effect of lithium and propantheline, an anticholinergic agent, combination on plasma and red blood cell (RBC) lithium levels was studied to test if this combination could maintain a stable plasma lithium level for a long-lasting period by delaying gastric emptying, in rabbits. There was a significant difference in plasma lithium levels between control and propantheline-administered groups (p < 0.01). The peak level seen in the second hour of lithium administration in the control group was not observed in the propantheline-administered group and a stable lithium level was maintained. It was suggested that a lithium and anticholinergic drug combination can be an alternative in eliminating the peak plasma levels of lithium and preventing the side-effects thought to be related to this factor