Ney ve keman icracılarında servikal bölge problemleri ve egzersiz eğitiminin etkinliği

Bu çalışma, servikal bölge problemlerine sahip olan 20 keman ve 20 ney icracısından oluşan 40 kişi üzerinde egzersiz eğitiminin etkinliğini gözlemlemek amacıyla planlandı. Ney ve keman icracıları iki farklı grup olarak değerlendirildi. Her iki gruba da 8 hafta boyunca haftanın 3 günü egzersiz eğitim programı uygulandı. Müzisyenlerin cinsiyet, yaş, boy, vücut ağırlığı ve enstrümanı günlük/yıllık kullanım süreleri gibi bilgileri kayıt altına alındı. Eklem hareket açıklığı için gonyometrik ölçüm, kas kuvveti için dijital kas dinamometresi, ağrı için visual analog skalası, fonksiyonel durum için northwick park boyun ağrısı anketi, fleksibilite için mezura, yaşam kalitesi için SF-36 ölçeği, kavrama kuvveti için handgrip dinamometresi kullanıldı. Ölçümler eğitim öncesi ve sonrası olmak üzere iki kez tekrarlandı. İstatistiksel analiz sonucunda; iki grupta da ağrı düzeylerinde azalma, boyun fleksiyonu yönünde eklem hareket açıklıklarında artış, sol trapeziusun orta, sağ deltoideusun ön ve orta parçası, boynun fleksör grup kaslarında ve sol el kavrama kuvvetinde anlamlı artışlar, çene-sternum ve çene-duvar mesafeleri ile yaşam kalitesinin sosyal fonksiyon skoru açısından pozitif yönde anlamlı sonuçlar görüldü. Ney icracılarında boynun sağ ve keman icracılarında boynun sol lateral fleksiyon eklem hareket açıklıklarında artış görüldü. Ney kullanıcılarında sol trapeziusun üst, sol deltoideusun ön parçası, keman kullanıcılarında ise sağ serratus anterior, sağ trapeziusun orta parçası ve boynun ekstansör kas kuvvetlerinde artış görüldü. Ney kullanıcılarında yaşam kalitesi ölçeğinin emosyonel iyilik hali skor değeri lehine anlamlı fark bulundu. Değerlendirmeye alınan diğer parametrelerde ise anlamlı fark görülmedi. Bu çalışma sonucunda ney ve keman icracılarında egzersiz eğitiminin servikal bölge problemlerinin tamamında olmasa da başta ağrı olmak üzere bazı parametlerde etkili olabileceği düşünüldü. Egzersiz eğitiminin etkilerini görebilmek için daha kapsamlı ve uzun takip gerektiren çalışmalara ihtiyaç olduğu sonucuna ulaşıldı

Dynamic nuclear polarization of spherical nanoparticles

Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.Spherical silica nanoparticles of various particle sizes (∼10 to 100 nm), produced by a modified Stoeber method employing amino acids as catalysts, are investigated using Dynamic Nuclear Polarization (DNP) enhanced Nuclear Magnetic Resonance (NMR) spectroscopy. This study includes ultra-sensitive detection of surface-bound amino acids and their supramolecular organization in trace amounts, exploiting the increase in NMR sensitivity of up to three orders of magnitude via DNP. Moreover, the nature of the silicon nuclei on the surface and the bulk silicon nuclei in the core (sub-surface) is characterized at atomic resolution. Thereby, we obtain unique insights into the surface chemistry of these nanoparticles, which might result in improving their rational design as required for promising applications, e.g. as catalysts or imaging contrast agents. The non-covalent binding of amino acids to surfaces was determined which shows that the amino acids not just function as catalysts but become incorporated into the nanoparticles during the formation process. As a result only three distinct Q-types of silica signals were observed from surface and core regions. We observed dramatic changes of DNP enhancements as a function of particle size, and very small particles (which suit in vivo applications better) were hyperpolarized with the best efficiency. Nearly one order of magnitude larger DNP enhancement was observed for nanoparticles with 13 nm size compared to particles with 100 nm size. We determined an approximate DNP penetration-depth (∼4.2 or ∼5.7 nm) for the polarization transfer from electrons to the nuclei of the spherical nanoparticles. Faster DNP polarization buildup was observed for larger nanoparticles. Efficient hyperpolarization of such nanoparticles, as achieved in this work, can be utilized in applications such as magnetic resonance imaging (MRI).DFG, GRK 1524, Self-Assembled Soft-Matter Nanostructures at Interface

Dynamic Nuclear Polarization of Deuterated Proteins

For D's a jolly good fellow: Deuteration of proteins significantly increases the signal enhancements observed in dynamic nuclear polarization (DNP) magic-angle spinning (MAS) NMR experiments. In 13C CP-MAS spectra an enhancement of 120 is observed for perdeuterated SH3 with an exchangeable proton ratio of 50 %, whereas the enhancement is only 31 for the fully protonated SH3. The direct 13C excitation of the perdeuterated sample increases the enhancement to 148

A rare case with suicide due to akathisia after use of single dose venlafaxine

Akathisia is a movement disorder characterized by an inner sense of unease, unrest and dysphoria.Suicidal behavior related with akathisia in patients is one of serious harmful behaviors and requires rapid intervention.There is limited number of cases about venlafaxine-associated akathisia in the literature, but it is not still yet known exactly what the actual incidence is.Side effects associated with antidepressants should be closely monitored and should be kept in mind without irreversible conditions. In this case report we will conclude about a case in which rapid development of akathisia and suicidal behavior occurs following venlafaxine treatment initiated with a non-psychiatric indication

Three-dimensional deuterium-carbon correlation experiments for high-resolution solid-state MAS NMR spectroscopy of large proteins

Well-resolved 2H-13C correlation spectra, reminiscent of 1H-13C correlations, are obtained for perdeuterated ubiquitin and for perdeuterated outer-membrane protein G (OmpG) from E. coli by exploiting the favorable lifetime of 2H double-quantum (DQ) states. Sufficient signal-to-noise was achieved due to the short deuterium T 1, allowing for high repetition rates and enabling 3D experiments with a 2H-13C transfer step in a reasonable time. Well-resolved 3D 2HDQ-13C-13C correlations of ubiquitin and OmpG were recorded within 3.5days each. An essentially complete assignment of 2HDQα shifts and of a substantial fraction of 2HDQβ shifts were obtained for ubiquitin. In the case of OmpG, 2HDQα and 2HDQβ chemical shifts of a considerable number of threonine, serine and leucine residues were assigned. This approach provides the basis for a general heteronuclear 3D MAS NMR assignment concept utilizing pulse sequences with 2HDQ-13C transfer steps and evolution of deuterium double-quantum chemical shift

Photocatalytic Activity of Mesoporous Graphitic Carbon Nitride (mpg-C3N4) Towards Organic Chromophores Under UV and VIS Light Illumination

A template-assisted synthetic method including the thermal polycondensation of guanidine hydrochloride (GndCl) was utilized to synthesize highly-organized mesoporous graphitic carbon nitride (mpg-C3N4) photocatalysts. Comprehensive structural analysis of the mpg-C3N4 materials were performed by XPS, XRD, FT-IR, BET and solid-state NMR spectroscopy. Photocatalytic performance of the mpg-C3N4 materials was studied for the photodegradation of several dyes under visible and UV light illumination as a function of catalyst loading and the structure of mpg-C3N4 depending on the polycondensation temperature. Among all of the formerly reported performances in the literature (including the ones for Degussa P25 commercial benchmark), currently synthesized mpg-C3N4 photocatalysts exhibit a significantly superior visible light-induced photocatalytic activity towards rhodamine B (RhB) dye. Enhanced catalytic efficiency could be mainly attributed to the terminated polycondensation process, high specific surface area, and mesoporous structure with a wide pore size distribution. © 2016, Springer Science+Business Media New York

Dynamic Nuclear Polarization NMR Spectroscopy Allows High-Throughput Characterization of Microporous Organic Polymers

Dynamic nuclear polarization (DNP) solid-state NMR was used to obtain natural abundance 13C and 15N CP MAS NMR spectra of microporous organic polymers with excellent signal-to-noise ratio, allowing for unprecedented details in the molecular structure to be determined for these complex polymer networks. Sensitivity enhancements larger than 10 were obtained with bis-nitroxide radical at 14.1 T and low temperature (∼105 K). This DNP MAS NMR approach allows efficient, high-throughput characterization of libraries of porous polymers prepared by combinatorial chemistry methods

Mesoporous Silica Nanoparticles Loaded with Surfactant: Low Temperature Magic Angle Spinning 13C and 29Si NMR Enhanced by Dynamic Nuclear Polarization

We show that dynamic nuclear polarization (DNP) can be used to enhance NMR signals of13C and 29Si nuclei located in mesoporous organic/inorganic hybrid materials, at several hundreds of nanometers from stable radicals (TOTAPOL) trapped in the surrounding frozen disordered water. The approach is demonstrated using mesoporous silica nanoparticles (MSN), functionalized with 3-(N-phenylureido)propyl (PUP) groups, filled with the surfactant cetyltrimethylammonium bromide (CTAB). The DNP-enhanced proton magnetization is transported into the mesopores via 1H–1H spin diffusion and transferred to rare spins by cross-polarization, yielding signal enhancements εon/off of around 8. When the CTAB molecules are extracted, so that the radicals can enter the mesopores, the enhancements increase to εon/off ≈ 30 for both nuclei. A quantitative analysis of the signal enhancements in MSN with and without surfactant is based on a one-dimensional proton spin diffusion model. The effect of solvent deuteration is also investigated