IN VIVO AND IN VITRO EFFECTS OF ARTEMISININ GROUP OF DRUGS ON TRYPANOSOMOSIS IN MICE

This study was done to study the effect of artemisinin groups of drugs on mice experimentally infected with the protozoan Trypanosoma brucei and on Trypanosoma brucei invitro. Commercial artesunate and artemether were used with diminazene aceturate serving as control. It was discovered that artemether administration resulted into seven days of aparasitaemia of trypanosomosis in vivo and reduced motility of the trypanosomes in vitro. There was synergistic effect in the action of artesunate and diminazene aceturate. In vitro analysis gave a similar result in that the trypanosome were found to be sensitive to artemether  with an MIC of 0.6µl,  artesunate with berenil combination and the artemether treatment group 2.5µM. The implication of these results is discussed and advice is given on the potential adaptation of artesunate for treatment of trypanosomosis and planting of Artemisia annua tree in the country.Â

Assessment of Biophilic Design Patterns on Skill Development, In Minna, Niger State

As an interactive sustainable alternative to existing sustainable design practices, biophilic design struggles to promote the possibility of merging the built and natural environment. The study is aimed at assessing the extent to which biophilic design patterns influences skill development in order to suggest interactive sustainable alternatives. The study adopted a mixed method of research. Qualitative data were obtained via the review of relevant literature while quantitative data were obtained via the use of a structured questionnaire administered to 32 respondents in the study population. The respondents were selected from the users of purposebuilt skill acquisition and development spaces in Minna, Niger state, to determine the level of satisfaction with the implementation of these patterns and considerations in skill acquisition and development space. The quantitative data was analysed with the use of statistical package for social sciences (SPSS) and the results presented descriptively with the use of tables. The findings suggest that most users were satisfied with patterns from nature in space patterns and natural analogue patterns relating to direct and indirect connection with natural system

EXPLORING SOURSOP KERNEL AS A SUSTAINABLE BIOFUEL: ANALYZING PHYSICAL AND SOLID FLOW PROPERTIES FOR FEASIBILITY ASSESSMENT

  Soursop kernel is an oil-bearing seed containing about 25% non-edible oil per 100 g sample making it a potential feedstock for biofuel production. However, exploring the full potential of the oil requires data to design and fabricate appropriate machines for its processing. So, this necessitates a thorough examination of its physical and solid flow behaviour in relation to moisture contents. The experiments conducted on rewetted samples revealed that as moisture content (mc) increased from 8% to 32.5% dry basis (db), the length, width, thickness, arithmetic and geometric mean diameter, volume, surface area, sphericity, and thousand kernels weight increased from 11.40-12.06 mm, 7.04-7.92 mm, 4.58-5.34 mm, 7.69-8.44 mm, 7.12-7.49 mm, 6.5–8.13 cm3, 160.19-199.05 mm2, 0.62- 0.66 and 186.4–291 g, respectively. The true density decreased from 720 to 670 kg/m³, whereas the bulk density increased from 470 to 570 kg/m³. The angle of repose linearly increased from 25.8° to 39.2° as moisture content increased. The highest mean values for coefficients of friction were observed on mild steel surfaces (0.44 for static and 0.53 for dynamic) at 8.0% mc (db) while the lowest values were recorded on stainless steel surfaces (0.20 for static and 0.37 for dynamic) at both 32.5% and 8.0%, (mc, db). The data obtained will prove beneficial to engineers in the design and development of appropriate machines, as well as other handling and processing equipment such as oil expellers, so as to explore the full industrial application of the oil for biodiesel production and other chemical productio

Medicine use among HIV/Aids patients in public hospitals, Kwara State

Background: The prognosis of HIV/AIDS and HIV-related comorbidities has been revolutionized by the use of medicines. However, World Health Organization reported that 50% of patients do not use their medicines as prescribed.Objective: To assess HIV/AIDS patients’ knowledge of the use of medicines dispensed to them.Method: This study was conducted in seven public hospitals in six local government areas, Kwara State. Exit interviews of 780 eligible HIV/AIDS patients were conducted through use of structured questionnaire. Additionally, there were exit observational checks of medicines dispensed to these patients. Descriptive statistics and Fisher Exact test were used for data analyses.Results: Of the 780 study participants, 36.1% had no formal education, 99.9% knew the ‘quantity’ of medicines to be administered, while 99.2% knew the frequency of administration. All the patients knew the route of administration, 96.7% and 94.3% knew the general precautions to avoid concomitant use of dispensed medicines with alcohol or herbal products respectively, while 93.7% of those who received co-trimoxazole knew of the precaution to use “plenty of water” as the vehicle for its administration. There were no significant associations between the patients’ knowledge of these precautions and duration of antiretroviral therapy (P>0.05). However, the patients lacked knowledge of specific precautions of some dispensed medicines.Conclusion: Most of the patients knew of the administration and the general precautions of dispensed medicines. However, lack of knowledge of specific precautions of some dispensed medicines calls for intervention.Keywords: HIV/AIDS patients, Medicine use, Duration of antiretroviral therapy, Public hospitals, Kwara Stat

MODELING THE PERFORMANCE OF A BAOBAB SEED DECORTICATOR USING RESPONSE SURFACE METHODOLOGY

Decortication of baobab seed manually after soaking or roasting is time consuming, labour-intensive and uneconomical. The demand for baobab kernel as a source of protein is increasing for use as supplement for animal protein ration, for edible oil consumption and for other industrial uses. To ameliorate this problem, a baobab seed decorticator has been developed. This study therefore focused on the effects of process parameters; moisture content of seed, speed of decorticator and concave-shaft clearance on percentage clean kernel (Pck), percentage broken kernel (Pbk), percentage whole seed (Pws) and decorticating efficiency (DE), using Response Surface Methodology (RSM). In designing the experiments, Box-Behnken Design (BBD) was selected. Analysis of Variance (ANOVA) was carried out to evaluate and select the appropriate dependent (Pck Pbk, Pws and DE) and independent variables using both the F and P-values calculated at 95% confidence level (a=0.05). Mathematical models relating the process parameters to the responses were developed. The developed models were validated by comparing the predicted and actual experimental values. The selected quadratic models were adequate for predicting the performance of the developed decorticator. It was observed that a decrease in percentage clean kernel recovery would result if concave-shaft clearance and moisture content were increased. Likewise, the concave-shaft clearance had the highest positive effect while moisture content had the highest negative effect on percentage of broken kernel. All the three factors (process parameters) had positive effects on decorticating efficiency

Design, fabrication and evaluation of fish meal pelletizing machine

A 113.1kg/h fish meal pellet processing machine which produced 4mm diameter pellet, with an average length of 6mm was designed and fabricated. Design values of 210 was used for the maximum angle that the hopper wall formed with the vertical in the discharge zone, a critical stress of 1.3kPa of the ground particulate materials, and a density of 2.4521kg/m3 of the particulate materials, were used to obtain a hopper smallest outlet diameter of 12.7cm with a capacity of 24,118cm3 which proved efficient for the pelletizing machine. Two 3-cm diameter shafts carried the speed reduction gears with the perforated disc attached to the roller cutters on one end, while at the other end a 5hp motor was connected to the speed reduction gear by pulleys with diameters of 6cm and 12cm respectively. The speed reduction was 1:5 over a motor speed of 2000rpm. The fish meal pelletizing machine utilized 4kg of ingredients to produce 3.77kg pellets at an efficiency of 94.2%. The percentage loss due to unprocessed ground particulate materials was 5.8%.The moisture content of the fish meal pellets after 7days of drying in open air was 26.5% (wet basis). When tested for floatation, the pellets stayed afloat for 9 days, while the un-dried pellets only remained afloat for 2days. A combination of the weight of the twin roller cutters and the addition of some starch to the ground particulate materials assisted the compacting and gelatinization of pellet formed. This machine will be useful to medium and small scale aquaculture farmers and also reduce the need for foreign sources of fish meal in the aquaculture industry, thus conserving foreign exchange.Keywords: Ground particulate materials; mixing; compacting; gelatinizing; pelletizin