15 research outputs found
A Multiplex Panel of Plasma Markers of Immunity and Inflammation in Classical Kaposi Sarcoma
Kaposi sarcoma (KS) risk is affected by perturbed immunity. Herein, we compared
plasma from 15 human immunodeficiency virus (HIV)-negative classic KS cases to
plasma from 29 matched controls, using a multiplex panel of immunity markers. Of
70 markers, CXCL10 (IP-10), sIL-1RII, sIL-2RA, and CCL3 (MIP-1A) were strongly
and significantly associated with KS, after adjustment for age and smoking
status. These and previous observations are consistent with a tumor-promoting
role for these cytokines, particularly CXCL10, but the small sample size and
case-control design preclude firm conclusions on KS risk or pathogenesis. Larger,well-designed prospective studies are needed to better assess the association of these markers with KS