2 research outputs found
Synthesis, Antibacterial And Toxicology Study Of MN(II), CO(II) AND NI(II) Metal Complexes Of Sulfadoxine Mixed With Pyrimethamine
ihree mixed ligand metal complexes of Sulphadoxine and Pyrimethamine were prepared by using Mn(II), Ni(II) and
Co(II) metal chloride hexahydrate and characterized by elemental analysis, molar conductivity, magnetic susceptibility
measurement, AAS, IR and UV-Vis. spectroscopy. Some physical parameters were obtained using molar conductance
• measurement and melting point determination. Based on the analytical and spectroscopic data, the complexes were
proposed to have the formulae: [ML1L2](Cl)2 (where M = Mn(II), Ni(II) and Co(II); L1 = sulphadoxine, L2 =
pyrimethamine). The spectroscopic data proposed that L1 and L2 coordinated through N ofNH2 groups in L1 and through
N atom of NH group in L2• Thus, pyramethamine was proposed to be a tridentate ligand, while sulphadoxine was
proposed to be a monodentate ligand. Micro-analysis further supported the proposed structure for the complexes. The
antibacterial activity of the metal complexes were compared with their ligands by screening them against isolates of
some strains of g(-) Escherichia coli, g(+) Proteus sp., g(+) Pseudomonas aureginosa and Salmonella typhi by using
diffusion method. The results obtained showed the metal complexes to be more potent antibacterial than the parent drugs
against the four species used. Toxicology tests against some tissues of albino rat (Rattus novergicuss) revealed toxicity of
the complexes in the kidney as compared to the parent drugs. However, ALP values for metal complexes were found to
be non-significantly different from the ALP values obtained for livers and the sera. This indicates that the metal
complexes are not excessively toxic