Crystal structure of tert-butyl 2-phenylethylcarbamate, C13H19NO2

Abstract C13H19NO2, monoclinic, P21/n (no. 14), a = 5.2692(3) Å, b = 13.8663(9) Å, c = 17.8020(13) Å, β = 93.323(6)°, V = 1298.50(15), Z = 4, R gt(F) = 0.0590, wR ref(F 2) = 0.1932, T = 293 K.</jats:p

Crystal structure of 4-(benzofuran-2-yl)-2-(3-(4-fluorophenyl)-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl)thiazole, C28H20FN3OS

Abstract C28H20FN3OS, triclinic, P1̅ (no. 2), a = 9.5719(5) Å, b = 10.7499(6) Å, c = 10.9238(5) Å, α = 95.470(4)°, β = 102.133(4)°, γ = 97.962(4)°, V = 1079.30(10) Å3, R gt(F) = 0.0482, wR ref(F 2) = 0.1143, T = 150(2) K.</jats:p

Reactions of organolithium reagents with quinazoline derivatives

This review deals with directed and regioselective lithiation of various quinazoline derivatives by the use of alkyllithiums in anhydrous THF at low temperature. Reactions of the lithium reagents obtained from the lithiation reactions with a range of electrophiles give the corresponding substituted derivatives in high yields. The procedures are simple, efficient and general to provide derivatives which might be difficult to produce by other means. In some cases nucleophilic addition of alkyllithiums takes place to produce the corresponding addition products via 1,2- and 3,4-additions. In other cases nucleophilic substitution or halogen-lithium exchange reactions occur

Crystal structure of 2-[4-(methylsulfanyl)quinazolin-2-yl]-1-phenylethanol

In the molecule of the title compound, C17H16N2OS, the almost planar methylsulfanylquinazoline group [the methyl C atom deviates by 0.032 (2) Å from the plane through the ring system] forms an interplanar angle of 76.26 (4)° with the plane of the phenyl group. An intramolecular O—H...N hydrogen bond is present between the quinazoline and hydroxy groups. In the crystal, molecules are stacked along the b-axis direction

Crystal structure of 2-(3-nitrophenyl)-1,3-thiazolo[4,5-b]pyridine

In the title compound, C12H7N3O2S, the dihedral angle between the planes of the thia­zolo­pyridine ring system (r.m.s. deviation = 0.005 Å) and the benzene ring is 3.94 (6)°. The nitro group is rotated by 7.6 (2)° from its attached ring. In the crystal, extensive aromatic [pi]-[pi] stacking [shortest centroid-centroid separation = 3.5295 (9) Å] links the mol­ecules into (001) sheets

Crystal structure of 2-[4-(methylsulfanyl)quinazolin-2-yl]-1-phenylethanol

In the mol­ecule of the title compound, C17H16N2OS, the almost planar methyl­sulfanylquinazoline group [the methyl C atom deviates by 0.032 (2) Å from the plane through the ring system] forms an inter­planar angle of 76.26 (4)° with the plane of the phenyl group. An intra­molecular O-H***N hydrogen bond is present between the quinazoline and hy­droxy groups. In the crystal, mol­ecules are stacked along the b-axis direction

Crystal structure of 2-cyclohexyl-1,3-thiazolo[4,5-b]pyridine

In the title compound, C12H14N2S, the cyclo­hexane ring adopts a chair conformation with the exocyclic C-C bond in an equatorial orientation. The mean plane through the cyclo­hexane ring (all atoms) is twisted from the thia­zolo­pyridine ring system (r.m.s. deviation = 0.013 Å) by 39.57 (6)°. In the crystal, mol­ecules form (100) sheets, although there are no specific directional inter­actions between them. The crystal stucture was refined as a two-component perfect twin