PL - 021 The research of High temperature exercise under different humidity environment effect on the body of water and salt metabolism

Objective Objective: This study was to investigate the body under high temperature (33 ℃) with different relative humidity (80%, 50%, 20%) combination of environment, respectively for 20 min 60% VO2max individual strength of quiet before and after the exposure of movement and under the same conditions, by measuring the participants within the body weight, serum sex hormone of blood, blood Na+、K+, Na+、K+ concentration in the urine of change, to explore in the sports stress and thermal stress of two kinds of stimulating the body water and salt metabolism characteristics, and to explore the effects of environmental humidity on the body's homeostasis. Methods Methods: This study selected 12 students of sports training major from Beijing sports university as subjects, with themselves as the control. The experiment is divided into six categories, respectively: high temperature 33℃ and 20% RH exposure group, the high temperature 33℃ and 20% RH campaign group, high temperature 33℃and 50% RH exposure group, the high temperature 33℃ and 50% RH campaign group, high temperature 33℃ and 80% RH exposure group and high temperature 33℃ and 80% RH. In this study all the environmental temperature are set up to 33℃, exercise intensity level of 60% VO2max selection for individual participants. Before every experiment, all participants were asked to quiet sit for 20 min and then measure the subjects' body weight, charge the subjects' vein blood and urine, take the same operation immediately after the experiment. Blood samples were stored at room temperature for 1 h, and 3000r/min was centrifuged for 20min. Serums were gathered through centrifugation, The urine and Serums were partial shipments in tube to be indicators of measurement. Serum Renin、ANGII、ALD、ADH、ANP、Na+、K+ concentration of serum and urine were tested Results Results:  (1)The subjects' weight loss percentage of exercise group was obviously higher than that of quiet exposure group, the difference is statistically significant (P < 0.01); In 80% RH environment weight loss percentage is significantly higher than that of 50% RH and 20% RH values (P < 0.01).There is no difference between 20%RH and 50%RH. (2) The exercise group of Renin, ANGII, ALD, ADH, concentration is significantly higher than the value of exposed group (P < 0.01), but the ANP concentrations were significantly lower than pure quiet exposure levels (P < 0.01). Conclusions Conclusions: (1) The body sweat more after exercise than just quiet exposed in high temperature, weight loss phenomenon more obvious; And with the increase of relative humidity environment,  dehydration will more serious. (2) Exercise factors can significantly promote the release of blood Renin, ANGII, ALD, ADH and   inhibit the release of ANP in the blood. By the way of strengthening the absorption process of water and ions, it can maintain the body's balance of water and ions

Go@Se@ni cathode materials for lithium-selenium battery

Selenium is a promising cathode material for high-energy lithium batteries. In this work, selenium was electrodeposited on nickel foam from aqueous selenite solution. The influences of pH values and current density on electrodeposited Se@Ni were investigated. It is found that electrodeposition at pH 7 and 0.5 mA cm −2 enables high current efficiency and produces uniform and smooth deposits. Graphene oxide (GO) was further coated on Se@Ni through physical adsorption to produce GO@Se@Ni. The developed GO@Se@Ni electrode delivers a high initial specific capacity of 593 mAh g −1 and good capacity retention over 100 cycles at 0.1 C

Femoral neck fracture after femoral head necrosis: a case report and review of the literature

Abstract Introduction Pathological fractures of the femoral neck caused by necrosis of the femoral head are extremely rare. Here, we report a rare case of bilateral femoral head osteonecrosis extending to the femoral neck, with bilateral pathological fractures of the femoral neck occurring within a short period of time. Case report A 65-year-old male with a 25-year history of daily consumption of 750 ml of liquor, presented with right hip pain after labor for 1 month. He subsequently sustained a right femoral neck fracture without trauma and underwent a right total hip arthroplasty. Two months later, he suffered a non-traumatic left femoral neck fracture and underwent a left total hip arthroplasty. Histopathological examination revealed osteonecrosis of the femoral head and neck, along with the presence of osteoclasts and granulomatous inflammation. Bone mineral density testing also showed osteoporosis. The bilateral femoral neck fractures were ruled out to be caused by any other pathological factors. Discussion This is the first report of pathological fractures of the bilateral femoral neck caused by femoral head necrosis. During the literature review process, we found that this case conforms to the histological characteristics of rapidly destructive hip disease and analyzed the etiology of femoral head necrosis and the pathogenesis of femoral neck fractures

Lacidipine Attenuates Apoptosis via a Caspase-3 Dependent Pathway in Human Kidney Cells

Background: Acute kidney injury (AKI) is common in hospitalised patients and has a poor prognosis. Therefore, new therapeutic strategies are anticipated. Lacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. However, its potential effect on renal injury remains unknown. In the present study, an in vitro model of renal ischemia reperfusion (I/R) injury was used to investigate the protective effect and underlying mechanisms of lacidipine on human kidney cell (HKC) apoptosis. Methods: HKCs were subjected to adenosine triphosphate (ATP) depletion and recovery (0.01 µM AA, depletion for 2 h and recovery for 30 min), with or without lacidipine (1 µM and 10 µM, 24 h), then cell viability and apoptosis were determined using the cell counting kit-8 (CCK-8) assay and Annexin V flow cytometry. The expression of Bcl-2, Bax, and cytochrome c (cyt c) was examined by western blot. Results: Antimycin A (AA) was found to induce apoptosis of HKCs. The proportion of early apoptosis and activity of caspase-3 peaked at 30 min after ATP depletion and recovery and were attenuated by lacidipine. The expression of cyt c and Bax was decreased, while that of Bcl-2 was increased significantly in lacidipine treated group. Conclusion: We conclude that lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway

Real-Time Data Transmission Scheduling Algorithm for Wireless Sensor Networks Based on Deep Q-Learning

In the industrial environment, the data transmission of Wireless Sensor Networks (WSNs) usually has strict deadline requirements. Improving the reliability and real-time performance of data transmission has become one of the critical issues in WSNs research. One of the main methods to improve the network performance of WSNs is to schedule the transmission process. An effective scheduling algorithm can meet the requirements of a strict industrial environment for network performance, which is of great research significance. Aiming at the problem of concurrent data transmission in WSNs, a real-time data transmission scheduling algorithm based on deep Q-learning is proposed. The algorithm comprehensively considers the influence of the remaining deadline, remaining hops, and unassigned time-slot nodes in the data transmission process, defines the reward function and action selection strategy of Q-learning, and guides the system state information transfer process. At the same time, deep learning and Q-learning are combined to solve the problem of disaster maintenance caused by the large scale of the system state. A multi-layer Stacked Auto Encoder (SAE) network model establishes the state-action mapping relationship, and the Q-learning algorithm updates it. Finally, according to the trained SAE network model, the data transmission scheduling strategy of the system in different states is obtained. The network performance of the proposed data transmission scheduling algorithm is analyzed and evaluated by simulation experiments. The simulation results show that compared with the commonly used heuristic algorithms, the proposed algorithm improves real-time performance and can better meet the data transmission requirements of high reliability and real-time WSNs

Development of an angiogenesis-promoting microvesicle-alginate-polycaprolactone composite graft for bone tissue engineering applications

One of the major challenges of bone tissue engineering applications is to construct a fully vascularized implant that can adapt to hypoxic environments in vivo. The incorporation of proangiogenic factors into scaffolds is a widely accepted method of achieving this goal. Recently, the proangiogenic potential of mesenchymal stem cell-derived microvesicles (MSC-MVs) has been confirmed in several studies. In the present study, we incorporated MSC-MVs into alginate-polycaprolactone (PCL) constructs that had previously been developed for bone tissue engineering applications, with the aim of promoting angiogenesis and bone regeneration. MSC-MVs were first isolated from the supernatant of rat bone marrow-derived MSCs and characterized by scanning electron microscopic, confocal microscopic, and flow cytometric analyses. The proangiogenic potential of MSC-MVs was demonstrated by the stimulation of tube formation of human umbilical vein endothelial cells in vitro. MSC-MVs and osteodifferentiated MSCs were then encapsulated with alginate and seeded onto porous three-dimensional printed PCL scaffolds. When combined with osteodifferentiated MSCs, the MV-alginate-PCL constructs enhanced vessel formation and tissue-engineered bone regeneration in a nude mouse subcutaneous bone formation model, as demonstrated by micro-computed tomographic, histological, and immunohistochemical analyses. This MV-alginate-PCL construct may offer a novel, proangiogenic, and cost-effective option for bone tissue engineering

Extraction, Purification, Structural Characteristics, Health Benefits, and Application of the Polysaccharides from <i>Lonicera japonica</i> Thunb.: A Review

Lonicera japonica Thunb. is a widely distributed plant with ornamental, economic, edible, and medicinal values. L. japonica is a phytoantibiotic with broad-spectrum antibacterial activity and a potent therapeutic effect on various infectious diseases. The anti-diabetic, anti-Alzheimer’s disease, anti-depression, antioxidative, immunoregulatory, anti-tumor, anti-inflammatory, anti-allergic, anti-gout, and anti-alcohol-addiction effects of L. japonica can also be explained by bioactive polysaccharides isolated from this plant. Several researchers have determined the molecular weight, chemical structure, and monosaccharide composition and ratio of L. japonica polysaccharides by water extraction and alcohol precipitation, enzyme-assisted extraction (EAE) and chromatography. This article searched in the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, and CNKI databases within the last 12 years, using “Lonicera. japonica polysaccharides”, “Lonicera. japonica Thunb. polysaccharides”, and “Honeysuckle polysaccharides” as the key word, systematically reviewed the extraction and purification methods, structural characteristics, structure-activity relationship, and health benefits of L. japonica polysaccharides to provide insights for future studies. Further, we elaborated on the potential applications of L. japonica polysaccharides in the food, medicine, and daily chemical industry, such as using L. japonica as raw material to make lozenges, soy sauce and toothpaste, etc. This review will be a useful reference for the further optimization of functional products developed from L. japonica polysaccharides