18 research outputs found
Making a move: care-home residents' experiences of relocation
This paper is based on data from older people concerning their experiences of relocating to a care home. It provides a framework to promote re-thinking of ways that older people are and can be involved in decision-making when making the move to a care home
Changes in Roman Catholic Beliefs and Practices in Ireland between 1981 and 2008 and the Emergence of the Liberal Catholic
Greater likelihood of remission in rheumatoid arthritis patients treated earlier in the disease course: results from the Consortium of Rheumatology Researchers of North America registry
OBJECTIVE: To examine whether disease duration is an independent predictor of achieving remission in rheumatoid arthritis (RA) patients initiating therapy.
METHODS: RA patients in the Consortium of Rheumatology Researchers of North America registry newly prescribed a nonbiologic disease-modifying antirheumatic drug (DMARD) or anti--tumor necrosis factor (anti-TNF) with at least one followup visit were identified.
RESULTS: Among the 1,646 nonbiologic DMARD initiators, CDAI remission occurred in 21.3% of those with ≤5 years of disease duration, 19.6% with 6-10 years, and 13.5% with greater than or equal to 11 years (P \u3c 0.001); sustained remission occurred in 10.2%, 8.8%, and 2.5%, respectively (P \u3c 0.001). Results were similar among the 3,179 anti-TNF initiators (CDAI remission in 22.3%, 17.7%, and 12.8%, respectively [P \u3c 0.001]; CDAI sustained remission in 9.7%, 9.5%, and 4.2%, respectively [P \u3c 0.001]). DAS28 results were similar in both groups. In adjusted analyses, an increase of disease duration by 5 years was associated with a reduced likelihood of CDAI remission in nonbiologic DMARD (odds ratio [OR] 0.91, 95% confidence interval [95% CI] 0.83-0.99) and anti-TNF initiators (OR 0.88, 95% CI 0.83-0.94). A similar result was seen for sustained remission using the CDAI (nonbiologic DMARD: OR 0.61, 95% CI 0.48-0.76; anti-TNF: OR 0.85, 95% CI 0.75-0.97).
CONCLUSION: Earlier treatment was associated with a greater likelihood of remission