Recent Results from the K2K Experiment

The K2K experiment has collected approximately half of its allocated protons on target between June of 1999 and July of 2001. These proceedings give a short introduction to the experiment and summarize some of the recent results.Comment: Invited talk at the Seventh International Workshop on Tau Lepton Physics (TAU02), Santa Cruz, Ca, USA, Sept 2002, 7 pages, LaTeX, 7 eps figures. PSN TH0

Complex interplay of kinetic factors governs the synergistic properties of HIV-1 entry inhibitors.

The homotrimeric HIV-1 envelope glycoprotein (Env) undergoes receptor-triggered structural changes that mediate viral entry through membrane fusion. This process is inhibited by chemokine receptor antagonists (CoRAs) that block Env-receptor interactions and by fusion inhibitors (FIs) that disrupt Env conformational transitions. Synergy between CoRAs and FIs has been attributed to a CoRA-dependent decrease in the rate of viral membrane fusion that extends the lifetime of the intermediate state targeted by FIs. Here, we demonstrated that the magnitude of CoRA/FI synergy unexpectedly depends on FI-binding affinity and the stoichiometry of chemokine receptor binding to trimeric Env. For C-peptide FIs (clinically represented by enfuvirtide), synergy waned as binding strength decreased until inhibitor combinations behaved additively. Curiously, this affinity dependence on synergy was absent for 5-Helix-type FIs. We linked this complex behavior to the CoRA dependence of Env deactivation following FI binding. For both FI classes, reducing chemokine receptor levels on target cells or eliminating competent chemokine receptor-binding sites on Env trimers resulted in a loss of synergistic activity. These data imply that the stoichiometry required for CoRA/FI synergy exceeds that required for HIV-1 entry. Our analysis suggests two distinct roles for chemokine receptor binding, one to trigger formation of the FI-sensitive intermediate state and another to facilitate subsequent conformational transitions. Together, our results could explain the wide variety of previously reported activities for CoRA/FI combinations. These findings also have implications for the combined use of CoRAs and FIs in antiviral therapies and point to a multifaceted role for chemokine receptor binding in promoting HIV-1 entry

Perturbing Around A Warped Product Of AdS_4 and Seven-Ellipsoid

We compute the spin-2 Kaluza-Klein modes around a warped product of AdS_4 and a seven-ellipsoid. This background with global G_2 symmetry is related to a U(N) x U(N) N=1 superconformal Chern-Simons matter theory with sixth order superpotential. The mass-squared in AdS_4 is quadratic in G_2 quantum number and KK excitation number. We determine the dimensions of spin-2 operators using the AdS/CFT correspondence. The connection to N=2 theory preserving SU(3) x U(1)_R is also discussed.Comment: 21pp; The second and last paragraphs of section 2, the footnotes 1 and 2 added and to appear in JHE

Efficient Schemes for Reducing Imperfect Collective Decoherences

We propose schemes that are efficient when each pair of qubits undergoes some imperfect collective decoherence with different baths. In the proposed scheme, each pair of qubits is first encoded in a decoherence-free subspace composed of two qubits. Leakage out of the encoding space generated by the imperfection is reduced by the quantum Zeno effect. Phase errors in the encoded bits generated by the imperfection are reduced by concatenation of the decoherence-free subspace with either a three-qubit quantum error correcting code that corrects only phase errors or a two-qubit quantum error detecting code that detects only phase errors, connected with the quantum Zeno effect again.Comment: no correction, 3 pages, RevTe