Current-excitation based ΔR-to-frequency converter for resistive sensors

This paper presents a relaxation oscillator-based high-resolution resistance measurement system. The proposed signal conditioning circuit utilizes a half-bridge topology with a bidirectional current excitation. The circuit modulates the incremental change in the sensor resistance in the form of a change in the frequency of the relaxation oscillator. The baseline resistance of the sensor is automatically compensated using a digital potentiometer at the beginning of the measurement cycle. The proposed circuit is analyzed in detail by considering the non-idealities of the circuit components. The design consideration is provided for different components. A prototype PCB of the proposed circuit is developed. The results show that the proposed circuit can provide a signal-to-noise ratio of 80 dB for a wide-range incremental change in the sensor resistance up to 500 kΩ with an error of less than ± 1%. The developed board is tested with humidity sensors. The result confirms the efficacy of the proposed circuit for a wide measurement range

Comparison among Ocular Response Analyzer, Corvis ST and Goldmann applanation tonometry in healthy children

AIM: To explore the relationship between different parameters of Ocular Response Analyzer (ORA) and Corvis ST (CST) in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure (IOP), measured by the Goldmann applanation tonometer (GAT-IOP), age and gender, and find possible correlation between ORA and CST with GAT. METHODS: This cross-sectional study included 90 healthy children. A general interview and complete eye examination were performed. Following successful GAT-IOP measurement, ORA and CST were conducted. The CST parameters were A 1/2 length (A1L, A2L), A 1/2 velocity (A1V, A2V), highest concavity deformation amplitude (HCDA), radius of curvature (RoC), peak distance (PD), central corneal thickness (CCT) and IOP. The ORA parameters were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOP-G) and corneal compensated IOP (IOP-CC). Extracted data was analyzed using the Statistical Package for Social Science software. RESULTS: Totally 39 males with age of 9.08±1.60 (6-12)y and 51 females with age of 8.96±1.55 (6-13)y were included. Many CST parameters were significantly correlated with CH, CRF, IOP-G and IOP-CC. Some CST parameters had a significant correlation with GAT-IOP, including IOP-CST in both eyes and HCDA, A2L, PD, and RoC in the left eye, but none with age, except A2L in the right eye. The CRF measurement showed a significant correlation with GAT-IOP in both eyes and CH in the right eye, yet, none with age. Among all CST and ORA parameters, CCT-CST in both eyes and A1L in right eye had a significant correlation with gender, although this was a negligible negative correlation. Comparison of mean IOP values by different devices showed a significantly highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Also, IOP-G versus IOP-CST significantly had the lowest IOP overestimation among others. Overall, either low positive correlation or negligible correlation was found between IOP measurements by 3 instruments. CONCLUSION: The study finds the highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Overall, either low positive correlation or negligible correlation is found between IOP measurements by the 3 instruments

Prevalence of color vision deficiency and its correlation with amblyopia and refractive errors among primary school children

Purpose: To determine the prevalence of color vision deficiency (CVD) and its correlation with amblyopia and refractive errors among primary school children. Methods: In this population-based cross-sectional study, 2160 children were selected from 36 primary schools; 60 students were from each school (10 students in each grade), with equal sex distribution. A complete eye examination including refraction using a photorefractometer, determination of visual acuity (VA) and color vision using a Yang vision tester, and evaluation of ocular media opacity using a direct ophthalmoscope was performed. Children who could not answer at least 4 plates of the Ishihara color test were considered as color vision deficient subjects. Amblyopia was determined if pinhole VA was worse than 0.3 LogMAR (equal to 20/40). Results: The prevalence of CVD was 2.2% (95% CI: 1.5% to 3%) which was higher in male subjects (37 [3.5%] boys vs. 11 [1.0%] girls, P < 0.001). Mean VA was lower among students with CVD as compared to normal color vision children (P = 0.035) and amblyopia was observed in 8.3% (95% CI: 0.2% to 16.4%) of patients with CVD versus 2.1% (95% CI: 1.5% to 2.08%) of children with normal color vision perception (P = 0.005). A statistically significant correlation between lower VA and CVD was observed (P = 0.023). Conclusion: Although CVD was correlated with lower VA and amblyopia, there was no relationship between CVD and the type of amblyopia, refractive error, anisometropia or strabismus

Accuracy and repeatability of refractive error measurements by photorefractometry

Purpose: To determine the accuracy of photorefraction and autorefraction as compared to cycloautorefraction and to detect the repeatability of photorefraction. Methods: This diagnostic study included the right eyes of 86 children aged 7-12 years. Refractive status was measured using photorefraction (PlusoptiX SO4, GmbH, Nürnberg, Germany) and autorefraction (Topcon RM800, USA) with and without cycloplegia. Photorefraction for each eye was performed three times to assess repeatability. Results: The overall agreement between photorefraction and cycloautorefraction was over 81% for all refractive errors. Photorefractometry had acceptable sensitivity and specificity for myopia and astigmatism. There was no statistically significant difference considering myopia and astigmatism in all comparisons, while the difference was significant for hyperopia using both amblyogenic (P = 0.006) and nonamblyogenic criteria (P = 0.001). A myopic shift of 1.21 diopter (D) and 1.58 D occurred with photorefraction in nonamblyogenic and amblyogenic hyperopia, respectively. Using revised cut-off points of + 1.12 D and + 2.6 D instead of + 2.00 D and + 3.50 D improved the sensitivity of photorefractometry to 84.62% and 69.23%, respectively. The repeatability of photorefraction for measurement of myopia, astigmatism and hyperopia was acceptable (intra-cluster correlation [ICC]: 0.98, 0.94 and 0.77, respectively). Autorefraction results were significantly different from cycloautorefraction in hyperopia (P < 0.0001), but comparable in myopia and astigmatism. Also, noncycloglegic autorefraction results were similar to photorefraction in this study. Conclusion: Although photorefraction was accurate for measurement of myopia and astigmatism, its sensitivity for hyperopia was low which could be improved by considering revised cut-off points. Considering cut-off points, photorefraction can be used as a screening method

Design analysis and experimental validation of relaxation oscillator-based circuit for R–C sensors

Relaxation oscillator-based circuits are widely used for interfacing various resistive and capacitive sensors. The electrical equivalent of most resistive and capacitive sensors is represented using a parallel combination of resistor and capacitor. The relaxation oscillator-based circuits are not suitable for parallel R–C sensors. In this paper, we propose a modified circuit for parallel R–C sensors. The proposed relaxation oscillator-based circuit is based on a dual-slope and charge transfer technique to measure the resistance and capacitance of parallel R–C sensors separately. In addition, the paper provides a detailed analysis and design considerations for the oscillator design by taking into account the various sources of non-idealities. A method to reduce the error by using single-cycle averaging is also introduced. To verify the analyzed design criteria, the circuit is tested with multiple operational amplifiers with different non-idealities. Experimental results verify the performance of the proposed circuit. The circuit is tested for a range from 10 pF to 42 pF and 100 kΩ to 1 MΩ for parallel R–C sensors with an error of less than 1.5%. The circuit is tested with a fabricated water-level sensor. The result confirms the efficacy of the proposed circuit

The relation between the severity of reading disorder and visual functions among children with dyslexia

PURPOSE: The purpose of the study was to investigate the relation between the severity of reading disorder and visual functions among children with dyslexia. MATERIALS AND METHODS: The present study included 32 dyslexic children selected from two centers for learning disabilities in Mashhad, Iran. Dyslexics were then classified as mild, moderate, and severe based on an instrument used to determine the severity of their reading disorder. Complete optometric examinations to measure visual acuity, refractive errors, latent and manifest deviations, stereoacuity, and amplitude of accommodation were performed for all participants. The correlation between visual functions among dyslexics and their reading disorder severity was investigated. RESULTS: The mean age of the participants in this study was 8.1 ± 0.8 years. Among participants, 40.6%, 31.3%, and 28.1% presented with severe, moderate, and mild levels of reading difficulties, respectively. Only exophoria significantly correlated with the severity of reading disorders. No significant correlation was found between other visual functions and the severity of reading disorders in dyslexic children. CONCLUSION: We found that higher exophoria at near has a significant correlation with the severity of dyslexia. A complete and detailed eye examination of patients with dyslexia and correcting their visual impairments might be helpful

Thread-based multiplexed sensor patch for real-time sweat monitoring

Abstract Sensor platforms that exploit the fibrous textile threads as substrates offer great promise since they can be directly sewn, woven or stitched on to any clothing. They can also be placed directly in intimate contact with the skin. In this work, we present a thread-based sensing platform in the form of a multiplexed sensing patch for continuous simultaneous on-skin monitoring of sweat. The patch performs real-time, on-body measurements of important biomarkers present in sweat such as electrolytes (sodium and ammonium ions), metabolites (lactate) and acidity (pH). Flexible threads coated with conductive inks were used as sensing electrodes. Selective potentiometric detection of electrolytes and pH was made possible through ion-selective membrane deposition and pH-sensitive polyaniline coating on threads, respectively. An amperometric enzymatic sensing scheme with lactate oxidase was used for the detection of lactate. An array of the thread sensors is integrated onto a patch with connectivity to a miniaturized circuit module containing a potentiostat, microprocessor and wireless circuitry for wireless smartphone readout. Extensive in vitro validation and an in vivo human pilot study involving a maximal exertion test show the promise of this platform for real-time physiological monitoring of human performance/fitness under stress, as well as diagnostic monitoring through sweat analysis