Canaanite Toponyms in Ancient Egyptian Documents

Jerusalemxix, 214 p.; 22 cm., ill, map

USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses

Usher syndrome type 3 (USH3) is an autosomal recessive disorder characterised by the association of post-lingual progressive hearing loss, progressive visual loss due to retinitis pigmentosa and variable presence of vestibular dysfunction. Because the previously defined transcripts do not account for all USH3 cases, we performed further analysis and revealed the presence of additional exons embedded in longer human and mouse USH3A transcripts and three novel USH3A mutations. Expression of Ush3a transcripts was localised by whole mount in situ hybridisation to cochlear hair cells and spiral ganglion cells. The full length USH3A transcript encodes clarin-1, a four-transmembrane-domain protein, which defines a novel vertebrate-specific family of three paralogues. Limited sequence homology to stargazin, a cerebellar synapse four-transmembrane-domain protein, suggests a role for clarin-1 in hair cell and photoreceptor cell synapses, as well as a common pathophysiological pathway for different Usher syndromes

Strengthening Biblical Historicity vis-à-vis Minimalism, 1992-2008 and Beyond, Part 2.2: The Literature of Perspective, Critique, and Methodology, Second Half

This series of articles covers scholarly works in English which can, at least potentially, be associated with a generally positive view of biblical historicity regarding periods preceding the Israelites’ return from exile. Part 2 covers works that treat the methodological issues at the center of the maximalist–minimalist debate. Parts 3–5 will cover works on evidences. This article completes the coverage, begun in the preceding article, of works that are neither maximalist nor minimalist, by treating select publications of Anthony J. Frendo, Nadav Na’aman, Israel Finkelstein, Andrew G. Vaughn, Baruch Halpern, Robert D. Miller II, and H. G. M. Williamson. It then discusses works on methodology by authors who espouse biblical historicity unless it is proven wrong, who are often called maximalists. It introduces these through the comments of Craig G. Bartholomew, then treats select works by Kenneth A. Kitchen, Jens Bruun Kofoed, Richard E. Averbeck, Iain W. Provan, V. Philips Long, and James K. Hoffmeier